Scutellaria baicalensis enema No.1 and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to radix scutellariae enema No.1 and a preparation method thereof. The enema liquid is prepared from the following medicinal materials by mass: 5 to 15 g of hedyotis diffusa, 10 to 30 g of codonopsis pilosula, 10 to 30 g of bighead atractylodes rhizome, 20 to 40 g of red peony root, 20 to 40 g of white peony root, 15 to 25 g of angelica sinensis, 10 to 30 g of coptis chinensis, 20 to 30 g of golden cypress, 15 to 25 g of scutellaria baicalensis, 10 to 30 g of salvia miltiorrhiza, 30 to 50 g of sophora flower, 30 to 50 g of coix seed, 20 to 30 g of hawthorn, 40 to 50 g of pulsatilla chinensis, 30 to 50 g of ash bark, 20 to 30 g of rheum officinale, 30 to 50 g of cortex moutan, 20 to 30 g of peach kernel, 20 to 40 g of safflower, 30 to 40 g of sophora flavescens, 20 to 30 g of patrinia and 1.5 to 2.5 g of borneol The traditional Chinese medicine composition has the beneficial effects of clearing away heat and toxic materials, cooling blood and removing dampness, promoting blood circulation to remove blood stasis, stopping dysentery and moistening intestines, and expelling pus and relieving pain through the pharmacological action and comprehensive action of the traditional Chinese medicinal materials; the traditional Chinese medicine is suitable for patients with chronic nonspecific ulcerative colitis, intestinal mucohyperemia and edema, unclear vascular texture, increased defecation frequency, non-formed stool and pus in stool.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to Scutellaria baicalensis enema solution No. 1 and a preparation method thereof. Background Art

[0002] Chronic nonspecific ulcerative colitis is an intestinal inflammatory disease of unknown etiology, which often causes abdominal pain, diarrhea, blood in the stool and other symptoms, seriously affecting the quality of life of patients. Existing treatment methods mostly rely on immunosuppressants, anti-inflammatory drugs, etc., but long-term use has obvious side effects and a high recurrence rate.

[0003] Traditional Chinese medicine has unique advantages in the treatment of chronic nonspecific ulcerative colitis, but traditional decoctions are inconvenient to take and have limited effects directly on intestinal lesions.

[0004] Therefore, we proposed Scutellaria baicalensis enema solution No. 1 and its preparation method to solve the above problems. Summary of the invention

[0005] In view of the problems existing in the prior art, the present invention discloses Scutellaria baicalensis enema solution No. 1 and a preparation method thereof. The technical scheme adopted is that the enema solution is prepared from the following medicinal materials in the following mass ratios: 5-15g of auricularia auricula, 10-30g of Codonopsis pilosula, 10-30g of Atractylodes macrocephala, 20-40g of Paeonia lactiflora, 20-40g of Paeonia lactiflora, 15-25g of Angelica sinensis, 10-30g of Coptis chinensis, 20-30g of Phellodendron chinense, g, Scutellaria baicalensis 15-25g, Salvia miltiorrhiza 10-30g, Sophora japonica 30-50g, Coix seed 30-50g, Crataegus pinnatifida 20-30g, Pulsatilla 40-50g, Qinpi 30-50g, Rhubarb 20-30g, Moutan bark 30-50g, Peach kernel 20-30g, Carthamus 20-40g, Sophora flavescens 30-40g, Patrinia 20-30g, Borneolum 1.5-2.5g.

[0006] As a preferred technical solution of the present invention, the enema solution is prepared by the following medicinal materials in the following mass ratio: 5g of auricularia auricula, 10g of Codonopsis pilosula, 10g of Atractylodes macrocephala, 20g of Red Peony Root, 20g of White Peony Root, 15g of Angelica sinensis, 10g of Coptis chinensis, 20g of Phellodendron chinense, 15g of Scutellaria baicalensis, 10g of Salvia miltiorrhiza, 30g of Sophora japonica, 30g of Coix seeds, 20g of Crataegus pinnatifida, 40g of Pulsatilla chinensis, 30g of Qinpi, 20g of Rhubarb, 30g of Moutan Cortex, 20g of Peach Kernel, 20g of Carthamus tinctorius, 30g of Sophora flavescens, 20g of Patrinia salviae, and 1.5g of Borneolum.

[0007] As a preferred technical solution of the present invention, the enema solution is prepared by the following medicinal materials in the following mass ratio: 10g of auricularia auricula, 20g of Codonopsis pilosula, 20g of Atractylodes macrocephala, 30g of red peony root, 30g of white peony root, 20g of Angelica sinensis, 20g of Coptis chinensis, 25g of Phellodendron chinense, 20g of Scutellaria baicalensis, 20g of Salvia miltiorrhiza, 40g of Sophora japonica flower, 40g of Coix seed, 25g of Crataegus pinnatifida, 45g of Pulsatilla chinensis, 40g of Qinpi, 25g of Rhubarb, 40g of Moutan bark, 25g of Peach kernel, 30g of Carthamus tinctorius, 35g of Sophora flavescens, 25g of Patrinia salviae, and 2g of Borneolum.

[0008] As a preferred technical solution of the present invention, the enema solution is prepared by the following medicinal materials in the following mass ratio: 15g of auricularia auricula, 30g of Codonopsis pilosula, 30g of Atractylodes macrocephala, 40g of Red Peony Root, 40g of White Peony Root, 25g of Angelica sinensis, 30g of Coptis chinensis, 30g of Phellodendron chinense, 25g of Scutellaria baicalensis, 30g of Salvia miltiorrhiza, 50g of Sophora japonica, 50g of Coix seeds, 30g of Crataegus pinnatifida, 50g of Pulsatilla striata, 50g of Qinpi, 30g of Rhubarb, 50g of Moutan Cortex, 30g of Peach Kernel, 40g of Carthamus tinctorius, 40g of Sophora flavescens, 30g of Patrinia salviae, and 2.5g of Borneolum.

[0009] As a preferred technical solution of the present invention, the enema solution is prepared by the following process, specifically by the following steps:

[0010] S1. Soak the above medicinal materials including herba scutellariae, dangshen, atractylodes, red peony root, white peony root, angelica, coptis root, phellodendron, scutellaria, salvia miltiorrhiza, sophora japonica, coix seed, hawthorn, pulsatilla, qinpi, rhubarb, moutan bark, peach kernel, safflower, sophora flavescens and patrinia chinensis in cold water for 30 minutes;

[0011] S2, then boil the medicinal materials soaked in cold water in S1 over high heat until boiling, then turn to low heat and boil for 30 minutes;

[0012] S3. Add borneol and boil for another 10 minutes to make 400 ml of liquid medicine. Divide it into 4 portions and put it in a pot for enema.

[0013] In the Scutellaria baicalensis enema solution No. 1 of the present invention and its preparation method, the effects and functions of each component are as follows:

[0014] Ear grass: bitter, cool in nature. Clears away heat, detoxifies, cools blood and reduces swelling.

[0015] Codonopsis: sweet, neutral. Tonifies the middle and replenishes Qi, harmonizes the stomach and produces body fluid, removes phlegm and relieves cough.

[0016] Atractylodes macrocephala: bitter, sweet, warm. Strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and stabilizes pregnancy.

[0017] Red Peony Root: bitter, slightly cold in nature. Enters the Liver Channel. Clears away heat, cools blood, disperses blood stasis and relieves pain.

[0018] White Peony Root: sweet, pungent, warm. Slightly toxic. Expels wind and dampness, detoxifies and calms spasms.

[0019] Angelica: sweet, pungent, warm. Enters the liver, heart, and spleen meridians. Nourishes blood; activates blood circulation; regulates menstruation and relieves pain; moisturizes and lubricates the intestines.

[0020] Coptis chinensis: bitter, cold in nature. Enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. Clears away heat and dampness, purges fire and detoxifies.

[0021] Phellodendron chinense: bitter, cold in nature. Kidney and bladder meridians. Clears away heat and dampness, purges fire and eliminates steam, detoxifies and treats sores.

[0022] Scutellaria baicalensis: Nature and flavor: bitter, cold. Enters the heart, lung, gallbladder, and large intestine meridians. It can purge excess fire, eliminate dampness and heat, stop bleeding, and stabilize pregnancy.

[0023] Danshen: bitter, slightly cold. Enters the heart and liver meridians. Promotes blood circulation and removes blood stasis, relieves menstruation and pain, clears the heart and relieves restlessness, cools blood and eliminates carbuncle.

[0024] Sophora japonica flower: cools and astringes, stops bleeding and lowers blood pressure.

[0025] Coix seeds: sweet, light, cool in nature. Enter the spleen, stomach, and lung meridians. Promote diuresis and eliminate dampness, strengthen the spleen and stop diarrhea, eliminate numbness, discharge pus, detoxify and disperse stagnation.

[0026] Hawthorn: helps digestion, strengthens the stomach, promotes qi and relieves blood stasis.

[0027] Pulsatilla: bitter, cold. Enters the stomach and large intestine meridians. Clears away heat and detoxifies, cools blood and stops dysentery.

[0028] Qinpi: bitter, astringent, cold in nature. Enters the liver, gallbladder, and large intestine meridians. Clears away heat and dampness, astringes and stops diarrhea, stops leukorrhea, and improves eyesight.

[0029] Rhubarb: bitter and cold in nature, it enters the stomach, large intestine, liver, and spleen meridians; it can attack stagnation, clear dampness and heat, purge fire, cool blood, remove blood stasis, and detoxify.

[0030] Cortex Moutan: bitter, pungent, slightly cold. Enters the heart, liver, and kidney meridians. Clears away heat, cools blood, and promotes blood circulation and removes stasis.

[0031] Peach kernel: bitter, sweet, neutral. Enters the heart, liver, and large intestine meridians. Promotes blood circulation, removes blood stasis, moistens the intestines and promotes bowel movements, relieves cough and asthma.

[0032] Safflower: spicy, warm in nature. Enters the heart and liver meridians. Promotes blood circulation, relieves blood stasis and relieves pain.

[0033] Sophora flavescens: bitter in taste, cold in nature. Enters the heart, liver, stomach, large intestine, and bladder meridians. Clears away heat and dampness, kills insects, and is a diuretic.

[0034] Patrinia scabra: cool in nature, pungent and bitter in taste. Enters the liver, stomach and large intestine meridians. Clears away heat and detoxifies, removes phlegm and discharges pus.

[0035] Borneol: pungent, bitter, cool in nature. Enters the heart, spleen, and lung meridians. Refreshes the mind, clears away heat and relieves pain.

[0036] The beneficial effects of the present invention are as follows: through the pharmacological effects of various Chinese medicinal materials and the comprehensive effects of the drugs, it can achieve the effects of clearing away heat and detoxifying, cooling blood and removing dampness, promoting blood circulation and removing blood stasis, stopping diarrhea and moistening the intestines, and discharging pus and relieving pain; it is suitable for patients with chronic nonspecific ulcerative colitis, intestinal waxy congestion and edema, unclear vascular texture, increased frequency of bowel movements, unformed stools, and pus in the stools. DETAILED DESCRIPTION

[0037] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] Embodiment 1

[0039] The invention discloses Scutellaria baicalensis enema liquid No. 1 and a preparation method thereof. The technical scheme adopted is that the enema liquid is prepared from the following medicinal materials in the following mass proportions: 5g of auricularia auricula, 10g of Codonopsis pilosula, 10g of Atractylodes macrocephala, 20g of Paeonia lactiflora, 20g of Paeonia lactiflora, 15g of Angelica sinensis, 10g of Coptis chinensis, 20g of Phellodendron amurense, 15g of Scutellaria baicalensis, 10g of Salvia miltiorrhiza, 30g of Sophora japonica flower, 30g of Coix seed, 20g of Crataegus pinnatifida, 40g of Pulsatilla chinensis, 30g of Cortex qinpi, 20g of Rhubarb, 30g of Cortex moutan, 20g of Semen persica, 20g of Carthamus tinctorius, 30g of Sophora flavescens, 20g of Patrinia salviae and 1.5g of Borneolum.

[0040] As a preferred technical solution of the present invention, the enema solution is prepared by the following process, specifically by the following steps:

[0041] S1. Soak the above medicinal materials including herba scutellariae, dangshen, atractylodes, red peony root, white peony root, angelica, coptis root, phellodendron, scutellaria, salvia miltiorrhiza, sophora japonica, coix seed, hawthorn, pulsatilla, qinpi, rhubarb, moutan bark, peach kernel, safflower, sophora flavescens and patrinia chinensis in cold water for 30 minutes;

[0042] S2, then boil the medicinal materials soaked in cold water in S1 over high heat until boiling, then turn to low heat and boil for 30 minutes;

[0043] S3. Add borneol and boil for another 10 minutes to make 400 ml of liquid medicine. Divide it into 4 portions and put it in a pot for enema.

[0044] Embodiment 2

[0045] As a preferred technical solution of the present invention, the enema solution is prepared by the following medicinal materials in the following mass ratio: 10g of auricularia auricula, 20g of Codonopsis pilosula, 20g of Atractylodes macrocephala, 30g of red peony root, 30g of white peony root, 20g of Angelica sinensis, 20g of Coptis chinensis, 25g of Phellodendron chinense, 20g of Scutellaria baicalensis, 20g of Salvia miltiorrhiza, 40g of Sophora japonica flower, 40g of Coix seed, 25g of Crataegus pinnatifida, 45g of Pulsatilla chinensis, 40g of Qinpi, 25g of Rhubarb, 40g of Moutan bark, 25g of Peach kernel, 30g of Carthamus tinctorius, 35g of Sophora flavescens, 25g of Patrinia salviae, and 2g of Borneol.

[0046] As a preferred technical solution of the present invention, the enema solution is prepared by the following process, specifically by the following steps:

[0047] S1. Soak the above medicinal materials including herba scutellariae, dangshen, atractylodes, red peony root, white peony root, angelica, coptis root, phellodendron, scutellaria, salvia miltiorrhiza, sophora japonica, coix seed, hawthorn, pulsatilla, qinpi, rhubarb, moutan bark, peach kernel, safflower, sophora flavescens and patrinia chinensis in cold water for 30 minutes;

[0048] S2, then boil the medicinal materials soaked in cold water in S1 over high heat until boiling, then turn to low heat and boil for 30 minutes;

[0049] S3. Add borneol and boil for another 10 minutes to make 400 ml of liquid medicine. Divide it into 4 portions and put it in a pot for enema.

[0050] Embodiment 3

[0051] As a preferred technical solution of the present invention, the enema solution is prepared by the following medicinal materials in the following mass ratio: 15g of auricularia auricula, 30g of Codonopsis pilosula, 30g of Atractylodes macrocephala, 40g of Red Peony Root, 40g of White Peony Root, 25g of Angelica sinensis, 30g of Coptis chinensis, 30g of Phellodendron chinense, 25g of Scutellaria baicalensis, 30g of Salvia miltiorrhiza, 50g of Sophora japonica, 50g of Coix seeds, 30g of Crataegus pinnatifida, 50g of Pulsatilla striata, 50g of Qinpi, 30g of Rhubarb, 50g of Moutan Cortex, 30g of Peach Kernel, 40g of Carthamus tinctorius, 40g of Sophora flavescens, 30g of Patrinia salviae, and 2.5g of Borneol.

[0052] As a preferred technical solution of the present invention, the enema solution is prepared by the following process, specifically by the following steps:

[0053] S1. Soak the above medicinal materials including herba scutellariae, dangshen, atractylodes, red peony root, white peony root, angelica, coptis root, phellodendron, scutellaria, salvia miltiorrhiza, sophora japonica, coix seed, hawthorn, pulsatilla, qinpi, rhubarb, moutan bark, peach kernel, safflower, sophora flavescens and patrinia chinensis in cold water for 30 minutes;

[0054] S2, then boil the medicinal materials soaked in cold water in S1 over high heat until boiling, then turn to low heat and boil for 30 minutes;

[0055] S3. Add borneol and boil for another 10 minutes to make 400 ml of liquid medicine. Divide it into 4 portions and put it in a pot for enema.

[0056] Embodiment 4

[0057] 80 cases of chronic nonspecific ulcerative colitis were diagnosed according to the Clinical Guidance for the Study of New Chinese Medicines, including 40 males and 40 females; the oldest was 65 years old, the youngest was 25 years old, and the average age was 45 years old; the longest course of disease was 15 years, the shortest was 1 year, and the average was 8 years. All patients were randomly divided into 40 experimental groups and 40 control groups. There was no statistically significant difference in the general data such as gender, age, and course of disease between the two groups, and they were comparable.

[0058] During the remission period of enteritis, there are abdominal pain, alternating diarrhea and constipation, mucus in the stool, bloody stool and tenesmus. Sigmoid colon or fiber colonoscopy examination can show: ① The affected colon mucosa is congested and edematous. ② The intestinal mucosa has a rough and granular appearance. ③ The colon pouches often become flat or blunt, and the pouches disappear. ④ Pathological changes in colon mucosal biopsy show an inflammatory reaction.

[0059] After the experiment started, the control group was given 1 sulfasalazine suppository (Heilongjiang Jiren Pharmaceutical Co., Ltd., National Medicine Standard H20067505), and anal insertion treatment every night before going to bed. The experimental group was given the Chinese medicine prescription retention enema of the present invention, the prescription composition: 5g of ear grass, 10g of Codonopsis pilosula, 10g of Atractylodes macrocephala, 20g of red peony root, 20g of white peony root, 15g of Angelica sinensis, 10g of Coptis chinensis, 20g of Phellodendron amurense, 15g of Scutellaria baicalensis, 10g of Salvia miltiorrhiza, 30g of Sophora japonica, 30g of Coix seeds, 20g of Crataegus pinnatifida, 40g of Pulsatilla chinensis, 30g of Qinpi, 20g of Rhubarb, 30g of Moutan bark, 20g of Peach kernel, 20g of Carthamus tinctorius, 30g of Sophora flavescens, 20g of Patrinia scabra, and 1.5g of Borneolum. Take one dose per day, decoct in water to extract 200ml of juice, and retain enema in a high position every night before going to bed. The method is: use a disposable infusion set, connect a small disposable anal tube, and lubricate with paraffin wax; 200mL of Chinese medicine enema solution is placed in a sterile infusion bottle at a temperature of 38-40℃; lie on the left side with knees bent, and raise the buttocks by 10-15cm. Slowly insert the disposable anal tube into the anus 10-15cm, and continue to insert the tube while infusing the liquid. The length of the tube is determined according to the location of the lesion. The usual length is 20-30cm. The infusion set speed is 40 drops / min, and it is appropriate for the patient to feel warmth in the lower abdomen and no discomfort. After enema, raise the elbow 10cm to prevent the liquid from overflowing, and retain it for at least 4h. Change the left stone lying position 3 or 4 times during the period to allow the liquid to fully contact the intestinal mucosa. It should be noted that during the treatment period, patients should ensure nutritional intake, eat small and frequent meals, eat easily digestible, light, high-calorie, high-protein, high-vitamin, low-fiber foods, and avoid eating raw, cold, spicy and other irritating foods. Pay attention to dietary hygiene to avoid intestinal infections that may aggravate the condition.

[0060] Both groups had 2 weeks as one course of treatment, rest for 2 days, and then the second course of treatment. The efficacy was statistically analyzed after 2 courses of treatment. The efficacy statistical criteria were: markedly effective: clinical symptoms disappeared, colonoscopy re-examination showed normal mucosa, medication was discontinued or only maintenance medication was used, and there was no recurrence after 6 months of observation; effective: clinical symptoms basically disappeared, colonoscopy re-examination showed mild inflammatory reaction of mucosa and partial pseudopolyp formation; ineffective: clinical symptoms, colonoscopy and pathological examination showed no improvement.

[0061] According to the test results in Table 1, it can be seen that the total effective rate of the control group is 70%, while the total effective rate of the test group is 90%. Obviously, the therapeutic effect of the test group is significantly better than that of the control group, which shows that the enema solution of the present invention has a better therapeutic effect on chronic nonspecific ulcerative colitis.

[0062] Table 1 Comparison of efficacy between the two groups

[0063]

[0064] 900 patients with various chronic nonspecific ulcerative colitis were selected. The specific classification is shown in the table below:

[0065]

[0066] Comparison of symptom treatment effects between the two groups

[0067]

[0068] From the above treatment results, the total effective rate of the pharmaceutical preparation of the present invention in treating anorectal diseases is 84.1%.

[0069] The formula ratios in Example 1, Example 2 and Example 3 can be appropriately selected for treatment according to the severity of the symptoms.

[0070] Embodiment 5

[0071] Case 1: Li XX, female, 61 years old

[0072] On July 25, 2023, the first diagnosis result of the rectal colonoscopy was as follows: the scope was inserted into the cavity to 5cm at the end of the ileum, the scope was inserted smoothly, the ileocecal valve was lip-shaped, no obvious abnormality was found in the appendix opening, a small amount of feces was found in the intestinal cavity, and the observation of some mucosa was unsatisfactory. When the scope was withdrawn to 8cm from the anal margin, the mucosa was granular, congested, edematous, and had longitudinal flaky shallow ulcers. The vascular network disappeared, and 2 biopsies were taken. The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were found; the examination conclusion: ulcerative colitis (active stage).

[0073] Treatment plan: Use 100 ml of the enema solution described in Example 2, perform enema once a day, and continue the treatment for 1 month.

[0074] On December 5, 2023, the results of the rectal colonoscopy follow-up were as follows: the scope was inserted into the ileum 5 cm in a loop, the scope was inserted smoothly, the ileocecal valve was lip-shaped, and there was no obvious abnormality in the opening of the rotten tail. There was a small amount of feces in the intestinal cavity, and the observation of some mucosa was unsatisfactory. When the scope was withdrawn to the sigmoid colon and rectum, the mucosa was rough, congested, and scattered flaky erythema, and the vascular texture was unclear, which was significantly improved compared with the previous film. The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were found; the conclusion of the examination.

[0075] Ulcerative colitis (in remission).

[0076] Case 2: Li XX, male, 20 years old

[0077] On July 12, 2023, the first colonoscopy results:

[0078] Insertion condition: smooth, slightly poor cleanliness;

[0079] Delivery site: ileocecal region;

[0080] Terminal ileum: no abnormality was found;

[0081] Ileocecal valve: No abnormality was found in morphology or mucosa;

[0082] Ascending colon: extensive congestion and edema of the mucosa, punctate erosion and bleeding, and blurred vascular texture;

[0083] Transverse colon: extensive congestion and edema of the mucosa, punctate erosion and bleeding, and blurred vascular texture;

[0084] Descending colon: extensive congestion and edema of the mucosa, punctate erosion and bleeding, unclear vascular texture;

[0085] Sigmoid colon: extensive congestion, edema, erosion, bleeding, and unclear vascular texture of the mucosa;

[0086] Rectum: The mucosa is extensively congested, edematous, eroded, and bleeding, and the biopsy is soft.

[0087] Examination conclusion: ulcerative colitis (active phase).

[0088] Treatment plan: Use 100 ml of the enema solution described in Example 1, perform enema once a day, and continue the treatment for 1 month.

[0089] On January 10, 2024, the results of the rectoscopy follow-up were as follows: the endoscope was inserted into the ileocecal region smoothly, the ileocecal valve was lip-shaped, no obvious abnormalities were found in the appendix opening, a small amount of feces was found in the intestinal cavity, and the observation of some mucosa was unsatisfactory. Scattered punctate erosions were seen when the endoscope was withdrawn to the descending colon, sigmoid colon, and rectum. The rest of the colon vascular network was clear, the colon pouch structure was normal, and no raised lesions or ulcers were found.

[0090] Examination conclusion: ulcerative colitis (remission period).

[0091] Case 3: Huang X, male, 38 years old

[0092] On April 22, 2024, the results of the first colonoscopy were as follows: the endoscope was inserted into the ileum 5 cm later, the insertion was smooth, the ileocecal valve was lip-shaped, the appendix opening was normal, a small amount of feces was in the intestinal cavity, and some mucosa observations were unsatisfactory. Diffuse mucosal congestion, edema, and erosion were observed in the rectum and sigmoid colon, which were easy to bleed, with a large amount of mucus attached, some mucosal shallow ulcers formed, the vascular network disappeared, and scattered punctate erosions were seen in the descending colon. Two pathological specimens were taken from the obvious rectal lesions. The rest of the colon vascular network was clear, the colon bag structure was normal, and no raised lesions or ulcers were found.

[0093] Examination conclusion: ulcerative colitis (active phase).

[0094] Treatment plan: Use 100 ml of the enema solution described in Example 3, perform enema once a day, and continue the treatment for 1 month.

[0095] On July 30, 2024, the results of the rectoscopy follow-up were as follows: the endoscope was inserted into the ileocecal part of the terminal ileum, the insertion was smooth, the ileocecal valve was lip-shaped, and there was no obvious abnormality in the opening of the tail rot. There was a small amount of feces in the intestinal cavity, and the observation of some mucosa was unsatisfactory. The endoscope was withdrawn to the sigmoid colon and rectal mucosa, and scattered acne-like erosions were seen. A piece of the descending colon was taken with forceps for examination. The rest of the colon vascular network was clear, the colon pouch structure was normal, and no raised lesions or ulcers were found.

[0096] Examination conclusion: ulcerative colitis (recovery stage).

[0097] Case 4: Chang XX, male, 62 years old

[0098] On April 2, 2024, the results of the first proctoscopy were as follows: the endoscope was inserted into the ileocecal region through the cavity, the insertion was smooth, the ileocecal valve was lip-shaped, no obvious abnormalities were found in the appendix opening, a small amount of feces was found in the intestinal cavity, and the observation of some mucosa was unsatisfactory. When the endoscope was withdrawn to the sigmoid colon and rectum, diffuse mucosal congestion, edema, and erosion were seen, shallow ulcers were formed, the vascular network disappeared, the vascular network of the rest of the colon was clear, the structure of the colon pouch was normal, and no raised lesions or ulcers were found.

[0099] Examination conclusion: ulcerative colitis (active phase).

[0100] Treatment plan: Use 100 ml of the enema solution described in Example 3, perform enema once a day, and continue the treatment for 1 month.

[0101] On July 22, 2024, the results of the rectal colonoscopy follow-up were as follows: the endoscope was inserted into the ileum smoothly, the ileocecal valve was lip-shaped, the mucosa was diffusely congested from the appendix opening to the blind end, the vascular texture was blurred, there was a small amount of feces in the intestinal cavity, and the observation of some mucosa was unsatisfactory. The mucosa was diffusely congested, edematous, and the vascular texture was unclear 30 to 20 meters from the anus. The anus was congested, edematous, and had punctate bleeding. The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were found.

[0102] Examination conclusion: ulcerative colitis (remission period).

[0103] Case 5: Yang XX, male, 53 years old

[0104] On April 22, 2024, the results of the first colonoscopy were as follows: the scope was inserted into the cavity to 5 cm at the end of the ileum, and the scope was inserted smoothly. The ileocecal valve was lip-shaped, and there was no obvious abnormality in the appendix opening. There was a large amount of feces in the intestinal cavity, which blocked the scope. The repeated flushing was ineffective, and the observation of some mucosa was unsatisfactory. A mucosal congestion and edema with a diameter of about 0.4 cm was seen at the end of the ileum, with a central depression and shallow ulcer formation. One biopsy was taken. Erosive mucosal congestion, edema, erosion, shallow ulcer formation, and disappearance of the vascular network were seen in the ileocecal region and ascending colon. Two biopsies were taken in the ascending colon. When the scope was withdrawn to the sigmoid and rectum, a large amount of white mucus was attached to the intestinal wall, and the mucosa was diffusely congested, edematous, eroded, shallow ulcers formed, and the vascular network disappeared. One pathological piece was taken from the sigmoid colon and rectum. The rest of the colon vascular network was clear, the colon bag structure was normal, and no raised lesions or ulcers were seen.

[0105] Examination conclusion: ulcerative colitis (active phase).

[0106] Treatment plan: Use 100 ml of the enema solution described in Example 2, perform enema once a day, and continue the treatment for 1 month.

[0107] On August 21, 2024, the results of the rectal colonoscopy follow-up were as follows: the scope was inserted into the cavity to 5 cm at the end of the ileum, and the scope was inserted smoothly. The ileocecal valve was lip-shaped, and there was no obvious abnormality in the opening of the rotten tail. There was a small amount of feces in the intestinal cavity. The observation of some mucosa was unsatisfactory. A diverticulum-like structure with a diameter of 0.3 cm was seen in the ileocecal part. When the scope was withdrawn to the sigmoid colon and rectum, scattered mucosal spots and sheets of mucosal congestion and edema were seen, and the vascular network was unclear (better than the previous film). The vascular network of the rest of the colon was clear, the colon bag structure was normal, and no raised lesions or ulcers were seen.

[0108] Examination conclusion: ulcerative colitis (recovery stage).

[0109] result

[0110] (1) Enema treatment using this enema solution can effectively alleviate the patient's clinical symptoms and physical and chemical indicators;

[0111] (2) No adverse events occurred before and after enema treatment using this enema solution, which shows that this treatment method is safe and reliable and worthy of clinical promotion.

[0112] Components not described in detail herein are prior art.

[0113] Although the specific embodiments of the present invention are described in detail above, the present invention is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in this field without departing from the purpose of the present invention, and modifications or deformations without creative labor are still within the protection scope of the present invention.

Claims

1. Scutellaria baicalensis enema solution No. 1, characterized in that: The enema solution is prepared from the following medicinal materials in the following mass ratio: 5-15g of auricularia auricula, 10-30g of Codonopsis pilosula, 10-30g of Atractylodes macrocephala, 20-40g of red peony root, 20-40g of white peony root, 15-25g of Angelica sinensis, 10-30g of Coptis chinensis, 20-30g of Phellodendron chinense, 15-25g of Scutellaria baicalensis, 10-30g of Salvia miltiorrhiza, 30-50g of Sophora japonica flower, 30-50g of Coix seed, 20-30g of Crataegus pinnatifida, 40-50g of Pulsatilla chinensis, 30-50g of Qinpi, 20-30g of Rhubarb, 30-50g of Moutan bark, 20-30g of peach kernel, 20-40g of Carthamus tinctorius, 30-40g of Sophora flavescens, 20-30g of Patrinia salviae, and 1.5-2.5g of Borneolum.

2. The Scutellaria baicalensis enema solution No. 1 according to claim 1, characterized in that: The enema solution is prepared with the following medicinal materials in the following mass ratio: 5g of auricularia auricula, 10g of Codonopsis pilosula, 10g of Atractylodes macrocephala, 20g of Red Peony Root, 20g of White Peony Root, 15g of Angelica sinensis, 10g of Coptis chinensis, 20g of Phellodendron chinense, 15g of Scutellaria baicalensis, 10g of Salvia miltiorrhiza, 30g of Sophora japonica flower, 30g of Coix seed, 20g of Crataegus pinnatifida, 40g of Pulsatilla chinensis, 30g of Qinpi, 20g of Rhubarb, 30g of Moutan bark, 20g of Peach Kernel, 20g of Carthamus tinctorius, 30g of Sophora flavescens, 20g of Patrinia salviae, and 1.5g of Borneolum.

3. The Scutellaria baicalensis enema solution No. 1 according to claim 1, characterized in that: The enema solution is prepared with the following medicinal materials in the following mass ratio: 10g of auricularia auricula, 20g of Codonopsis pilosula, 20g of Atractylodes macrocephala, 30g of Red Peony Root, 30g of White Peony Root, 20g of Angelica sinensis, 20g of Coptis chinensis, 25g of Phellodendron amurense, 20g of Scutellaria baicalensis, 20g of Salvia miltiorrhiza, 40g of Sophora japonica flower, 40g of Coix seed, 25g of Crataegus pinnatifida, 45g of Pulsatilla chinensis, 40g of Qinpi, 25g of Rhubarb, 40g of Moutan bark, 25g of Peach kernel, 30g of Carthamus tinctorius, 35g of Sophora flavescens, 25g of Patrinia salviae, and 2g of Borneolum.

4. The Scutellaria baicalensis enema solution No. 1 according to claim 1, characterized in that: The enema solution is prepared with the following medicinal materials in the following mass ratio: 15g of auricularia auricula, 30g of Codonopsis pilosula, 30g of Atractylodes macrocephala, 40g of Paeonia lactiflora, 40g of Paeonia lactiflora, 25g of Angelica sinensis, 30g of Coptis chinensis, 30g of Phellodendron chinense, 25g of Scutellaria baicalensis, 30g of Salvia miltiorrhiza, 50g of Sophora japonica flower, 50g of Coix seed, 30g of Crataegus pinnatifida, 50g of Pulsatilla striata, 50g of Qinpi, 30g of Rhubarb, 50g of Moutan bark, 30g of Peach kernel, 40g of Carthamus tinctorius, 40g of Sophora flavescens, 30g of Patrinia salviae, and 2.5g of Borneolum.

5. The Scutellaria baicalensis enema solution No. 1 according to any one of claims 1 to 4 is prepared by the following process, specifically by the following steps: S1. Soak the above medicinal materials including herba scutellariae, dangshen, atractylodes, red peony root, white peony root, angelica, coptis root, phellodendron, scutellaria, salvia miltiorrhiza, sophora japonica, coix seed, hawthorn, pulsatilla, qinpi, rhubarb, moutan bark, peach kernel, safflower, sophora flavescens and patrinia chinensis in cold water for 30 minutes; S2, then boil the medicinal materials soaked in cold water in S1 over high heat until boiling, then turn to low heat and boil for 30 minutes; S3. Add borneol and boil for another 10 minutes to make 400 ml of liquid medicine. Divide it into 4 portions and put it in a pot for enema.

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