Traditional Chinese medicine compound preparation for treating lumbar disc herniation and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating lumbar disc herniation and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicines. The preparation comprises eucommia ulmoides, radix angelicae pubescentis, angelica sinensis, ligusticum wallichii, radix achyranthis bidentatae, salvia miltiorrhiza, loranthus parasiticus, frankincense, myrrh, radix angelicae and turmeric. The traditional Chinese medicine compound preparation disclosed by the invention is evolved by an ancient prescription, is fused with a new safe medical treatment thought, is used for many years in our department, has a definite clinical curative effect, can effectively relieve clinical symptoms of patients with lumbar disc herniation, and can enhance the curative effect by combining traditional Chinese medicine and western medicine (matched with western medicine).

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine compound preparation for treating lumbar disc herniation and a preparation method thereof. Background Art

[0002] The lumbar disc is located between two vertebrae. It is a structure with fluid mechanics. It consists of three parts: nucleus pulposus, annulus fibrosus and cartilage plate. The nucleus pulposus is the central part, the annulus fibrosus is the peripheral part, surrounding the nucleus pulposus, and the cartilage plate is the upper and lower parts, directly connected to the vertebral bone tissue. Lumbar disc herniation (LDH) refers to a syndrome characterized by low back pain and numbness and pain in the lower limbs caused by the nucleus pulposus protruding from the damaged annulus fibrosus and compressing the nerve roots. The pathological mechanism of LDH includes mechanical stimulation of the protruding nucleus pulposus on the dura mater and nerve roots, as well as the resulting obstruction of blood supply to the nerve tissue, inflammatory reaction of the nerve roots, and immune response of the body. The highest incidence is L4 / 5 and L5 S1. Lumbar disc herniation is a medical problem worldwide, which has brought a huge economic burden to society and seriously reduced the quality of life of patients. More than 84% of adult patients have suffered from low back pain in their lifetime, and about 12% of low back pain patients will affect their work and quality of life in a day. Moreover, lumbar disc herniation is often difficult to cure. An Australian study found that 28% of patients with low back pain did not fully recover within one year after the initial diagnosis. Another health economics analysis showed that lumbar disc herniation is one of the most expensive diseases in the UK, with direct and indirect treatment costs and related production losses reaching 10.668 billion pounds. Western medicine treatment is mostly in the form of Western medicine and surgery. Western medicine often chooses non-steroidal anti-inflammatory drugs, but gastrointestinal and cardiovascular side effects often occur. Surgical treatment is mostly for patients with larger protrusions and more severe symptoms. This method is traumatic, expensive, and not well accepted by patients. Therefore, it is particularly important to choose a treatment method that is appropriate, effective, and safe.

[0003] Lumbar disc herniation belongs to the category of "low back pain" and "arthralgia" in traditional Chinese medicine. "Suwen·Arthralgia" states that "kidney arthralgia is prone to swelling, with the buttocks replacing the heels and the spine replacing the head". Another example is "Zhengzhi Zhunsheng·Waist and Hip Pain" which states that "low back pain pulls the feet, knees, and popliteal fossa, and pain lasts all night". Traditional Chinese medicine believes that the pathogenesis of this disease is mainly due to kidney essence deficiency, lack of biochemical sources, and kidney's inability to control bones, resulting in symptoms such as low back and leg pain. At the same time, due to kidney essence deficiency, after the evil enters the collaterals, the blood circulation is not smooth, which can easily cause blood stasis and qi stagnation. Therefore, this disease is based on "kidney deficiency" and "blood stasis" as the symptom. The method of tonifying the kidney and activating blood circulation is the basic treatment principle of traditional Chinese medicine for the prevention and treatment of IDD. Summary of the invention

[0004] To this end, the present invention provides a Chinese medicinal compound preparation for treating lumbar disc herniation and a preparation method thereof to solve the above-mentioned problems.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] According to the first aspect of the present invention, a composition for treating lumbar disc herniation is provided, wherein the preparation comprises Eucommia ulmoides, Angelica dahurica, Angelica sinensis, Ligusticum chuanxiong, Achyranthes bidentata, Salvia miltiorrhiza, Morus alba, frankincense, myrrh, Angelica dahurica, and Curcuma longa.

[0007] Furthermore, the preparation comprises the following raw materials: 5-15 parts of Eucommia ulmoides, 10-20 parts of Angelica sinensis, 5-15 parts of Ligusticum chuanxiong, 10-20 parts of Achyranthes bidentata, 5-15 parts of Salvia miltiorrhiza, 10-20 parts of Viscum album, 3-10 parts of frankincense, 3-10 parts of myrrh, 5-15 parts of Angelica dahurica, and 5-15 parts of Curcuma longa.

[0008] Furthermore, the preparation includes the following raw materials: 10 parts of Eucommia ulmoides, 15 parts of Angelica dahurica, 12 parts of Angelica sinensis, 10 parts of Ligusticum chuanxiong, 12 parts of Achyranthes bidentata, 10 parts of Salvia miltiorrhiza, 12 parts of Viscum album, 6 parts of frankincense, 6 parts of myrrh, 10 parts of Angelica dahurica, and 10 parts of Curcuma longa.

[0009] According to the second aspect of the present invention, a Chinese medicine compound preparation for treating lumbar disc herniation comprises the above-mentioned Chinese medicine composition and a pharmaceutically acceptable carrier or diluent.

[0010] Furthermore, the Chinese medicine compound preparation is in the form of granules, tablets, capsules, pills, decoctions, or syrups.

[0011] Furthermore, the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of a filler, a binder, a disintegrant, a lubricant, a surfactant or a flavoring agent.

[0012] Furthermore, the filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose.

[0013] Furthermore, the adhesive is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone.

[0014] Reasonable compatibility of the compound preparation of the present invention: The components in the Chinese medicine compound preparation need to be reasonably compatible. For example, Eucommia ulmoides and Morus alba both have the effect of strengthening muscles and bones, and can work together to treat lumbar disc herniation; while Chuanxiong and Achyranthes bidentata can work together to promote blood circulation, remove blood stasis, dredge meridians and relieve pain.

[0015] The Chinese medicine compound preparation for treating lumbar disc herniation of the present invention is usually composed according to the theory of zangfu meridians and the theory of four qi and five flavors of medicines of traditional Chinese medicine. By observing the effects and side effects of the medicines and the relationship between the medicines, it is possible to understand how the preparation treats lumbar disc herniation.

[0016] The eucommia bark, angelica root, chuanxiong, achyranthes bidentata, salvia miltiorrhiza, mistletoe, frankincense, myrrh, angelica root and turmeric used in the present invention are all commonly used Chinese medicines, each having different pharmacological effects. Eucommia bark has the effects of tonifying kidney and strengthening bones, reducing swelling and relieving pain; angelica root has the effects of removing rheumatism and relieving pain; angelica root has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain; chuanxiong has the effects of promoting blood circulation and promoting qi, dispelling wind and relieving pain; achyranthes bidentata has the effects of promoting blood circulation and dredging menstruation, and guiding medicine downward; salvia miltiorrhiza has the effects of promoting blood circulation and removing blood stasis, and relieving pain; mistletoe has the effects of tonifying liver and kidney, and removing rheumatism; frankincense has the effects of promoting blood circulation and relieving pain, reducing swelling and promoting tissue regeneration; myrrh has the effects of dispersing blood stasis and relieving pain, reducing swelling and promoting tissue regeneration; angelica root has the effects of removing rheumatism and relieving pain; turmeric has the effects of promoting blood circulation and promoting qi, and relieving pain. These Chinese medicines work together to achieve the purposes of promoting blood circulation and removing blood stasis, removing rheumatism and relieving pain, thereby effectively treating lumbar disc herniation. However, when using this Chinese medicine compound preparation, you should follow the doctor's advice and use it according to the prescribed dosage and usage to ensure safety and effectiveness. At the same time, for patients with severe lumbar disc herniation, comprehensive treatment should be adopted, including drug therapy, physical therapy, rehabilitation training, etc., to achieve better treatment effects.

[0017] The dosage form of the preparation of the present invention is selected: according to the properties of the drug and the specific conditions of the patient, a suitable dosage form of the preparation is selected. For example, for patients with lumbar disc herniation, oral administration methods such as decoction, pills, capsules or tablets can be selected to facilitate the patient's administration.

[0018] The present invention has the following advantages:

[0019] The kidney-tonifying and blood-activating prescription in the present invention has long been a conventional prescription for treating lumbago. The present invention is derived from the prescription for waist, hip and foot pain (eucommia bark, angelica sinensis, chuanxiong, rehmannia root, salvia miltiorrhiza) in "Wai Tai Mi Yao" with additions and subtractions. The kidney-tonifying and blood-activating prescription removes rehmannia root, adds mistletoe and Achyranthes bidentata to increase the effect of tonifying the kidney and strengthening the waist, adds frankincense and myrrh to increase the effect of promoting blood circulation and removing blood stasis, and adds angelica dahurica and turmeric to promote qi and relieve pain. The whole prescription has the effects of tonifying the kidney, promoting blood circulation, and promoting qi and relieving pain.

[0020] The Chinese medicine compound preparation of the present invention is evolved from ancient prescriptions and integrates the medical treatment ideas of Xin'an medicine. It has been used clinically for many years and has clear clinical efficacy. The compound preparation can effectively alleviate the clinical symptoms of patients with lumbar disc herniation, and the combination of Chinese and Western medicine (with Western medicine) can enhance the efficacy. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the implementation methods of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the implementation methods or the description of the prior art. Obviously, the drawings in the following description are only exemplary, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

[0022] The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification so as to facilitate understanding and reading by persons familiar with the technology. They are not used to limit the conditions under which the present invention can be implemented, and therefore have no substantial technical significance. Any structural modification, change in proportion or adjustment of size shall still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0023] Figure 1 The "active ingredient-target" network construction of a compound preparation of Example 1 provided in the experimental example of the present invention;

[0024] Figure 2 The common target of the compound preparation of Example 1 and lumbar disc herniation provided as an experimental example of the present invention;

[0025] Figure 3 A diagram of the target protein network provided in the experimental examples of the present invention;

[0026] Figure 4 GO analysis and KEGG pathway analysis of potential target proteins of the compound preparation of Example 1 for treating lumbar disc herniation provided in the experimental examples of the present invention;

[0027] Figure 5 The target-pathway interaction network screening diagram of the compound preparation of Example 1 provided as an experimental example of the present invention. DETAILED DESCRIPTION

[0028] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] Example 1

[0030] This embodiment provides a Chinese medicine compound preparation for treating lumbar disc herniation:

[0031] Ingredients: Eucommia ulmoides 10g, Duhuo 15g, Angelica sinensis 12g, Ligusticum chuanxiong 10g, Achyranthes bidentata 12g, Salvia miltiorrhiza 10g, Viscum album 12g, frankincense 6g, myrrh 6g, Angelica dahurica 10g, Curcuma longa 10g.

[0032] Example 2

[0033] This embodiment provides a Chinese medicine compound preparation for treating lumbar disc herniation:

[0034] Ingredients: 5 parts of Eucommia ulmoides, 10 parts of Angelica sinensis, 5 parts of Ligusticum chuanxiong, 10 parts of Achyranthes bidentata, 5 parts of Salvia miltiorrhiza, 10 parts of Viscum album, 3 parts of frankincense, 3 parts of myrrh, 5 parts of Angelica dahurica, and 5 parts of turmeric.

[0035] Example 3

[0036] This embodiment provides a Chinese medicine compound preparation for treating lumbar disc herniation:

[0037] Ingredients: 15 parts of Eucommia ulmoides, 20 parts of Angelica sinensis, 15 parts of Ligusticum chuanxiong, 20 parts of Achyranthes bidentata, 15 parts of Salvia miltiorrhiza, 20 parts of Viscum album, 10 parts of frankincense, 10 parts of myrrh, 15 parts of Angelica dahurica, and 15 parts of turmeric.

[0038] Example 4

[0039] A traditional Chinese medicine preparation for treating lumbar disc herniation, wherein the traditional Chinese medicine preparation is prepared into a decoction by a conventional method from the traditional Chinese medicine composition described in Examples 1 to 3.

[0040] Specifically, step 1, mix the raw materials according to the above formula, add water to soak the medicine surface for 60 minutes;

[0041] Step 2: Continue to add water to the formula raw materials soaked in step 1 until the surface of the medicine is 3-4 cm above the medicine surface, boil over high heat until boiling, then continue to boil over low heat for 60 minutes until the remaining medicine liquid is concentrated to 100 mL, filter, and take the filtrate for later use;

[0042] Step 3: Continue to add water to the remaining medicine obtained in step 2 until it covers the medicine surface by 2-3 cm. Boil over high heat until boiling, then simmer over low heat for 60 minutes. Filter until the remaining medicine liquid is concentrated to 100 mL. Take the filtrate and mix it with the filtrate obtained in step 2.

[0043] Example 5

[0044] A Chinese medicine preparation for treating lumbar disc herniation, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0045] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent, and granulate and dry according to conventional methods to prepare Chinese medicine granules.

[0046] Example 6

[0047] A Chinese medicine preparation for treating lumbar disc herniation, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0048] Take the Chinese medicine composition described in Examples 1 to 3, crush the above raw materials, add a pharmaceutically acceptable carrier or diluent, granulate according to conventional methods, fill capsules, and prepare Chinese medicine capsules.

[0049] Example 7

[0050] A Chinese medicine preparation for treating lumbar disc herniation, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0051] Take the Chinese medicine composition described in Examples 1 to 3, crush the above raw materials, add a pharmaceutically acceptable carrier or diluent, and prepare Chinese medicine pills according to conventional molding or panning methods.

[0052] Example 8

[0053] A Chinese medicine preparation for treating lumbar disc herniation, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0054] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent, press into tablets according to conventional methods, and apply film coating to obtain Chinese medicine tablets.

[0055] Example 9

[0056] A Chinese medicine preparation for treating lumbar disc herniation, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of a filler, a binder, a disintegrant, a lubricant, a surfactant or a flavoring agent. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of a cellulose derivative, alginate, gelatin or polyvinyl pyrrolidone.

[0057] The preparation method is as follows:

[0058] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent such as sucrose, etc., and prepare a Chinese medicine syrup according to a conventional method.

[0059] Experimental example

[0060] 1. Use network pharmacology to study the potential mechanism of Bushen Huoxue prescription in treating lumbar disc herniation

[0061] like Figure 1-5As shown, the main active ingredients and corresponding targets of the compound preparation of Example 1 were collected through the TCMSP database, and the "active ingredient-target" pathway of the compound preparation of Example 1 was constructed using Cytoscape. The pathogenic targets of LHD were obtained and compared using GeneCards, OMIM and CTD disease databases. The protein-protein interaction (PPI) network was constructed and analyzed with the help of the STRING online database. The GO (Geneontology) annotations and KEGG pathways of the action targets were enriched based on the Metascape database. Finally, the "active ingredient-target-pathway" network diagram of the Bushen Huoxue prescription for the treatment of LDH was constructed using Cytoscape3.7.2 to explore the possible targets and action pathways of the Bushen Huoxue prescription for the treatment of LDH. The results showed that there were 159 active ingredients in the Bushen Huoxue recipe corresponding to 241 targets, of which 85 important targets were closely related to its treatment of LDH. PPI network analysis showed that 13 targets such as AKT1, IL6, TP53, TNF, and IL1B were hub targets. GO functional annotation analysis showed that the active ingredients of the compound preparation of Example 1 had the effects of promoting cell proliferation, increasing protein binding activity, and enzyme activation reaction. KEGG results showed that the main role of Bushen Huoxue may be related to signaling pathways such as cancer pathways, AGE-RAGE signaling pathway in diabetic complications, and IL-17 signaling pathway.

[0062] 2. Clinical efficacy

[0063] In order to understand the clinical efficacy of the compound preparation for invigorating the kidney and activating blood circulation prepared in Example 1, the present invention carried out a clinical trial, the intervention group was the compound preparation of Example 1 combined with celecoxib, and the control group only used celecoxib, each group had 30 cases, and the specific results are shown in Tables 1-3. The study shows that the compound preparation of the present invention can well relieve the pain symptoms of patients with lumbar disc herniation and improve their functional status.

[0064] (1) VAS scores of patients in the two groups

[0065] There was no significant difference in VAS scores between the two groups before treatment (P>0.05); after treatment, the VAS scores of the two groups were significantly lower than those before treatment, and the difference was statistically significant (P<0.05); the VAS score of the intervention group was lower than that of the control group after treatment, and the difference was statistically significant (P<0.05), as shown in Table 1.

[0066] Table 1 Comparison of VAS scores between the two groups before and after treatment point

[0067]

[0068] Note: Compared with the group before treatment, *P<0.05, compared with the control group after treatment, △P<0.05.

[0069] As shown in Table 1, the Bushen Huoxue recipe can significantly relieve the pain symptoms of patients with lumbar disc herniation.

[0070] (2) ODI index of the two groups of patients

[0071] There was no significant difference in the ODI index between the two groups before treatment (P>0.05); after treatment, the ODI index of the two groups was significantly lower than that before treatment, and the difference was statistically significant (P<0.05); the ODI index of the intervention group was lower than that of the control group after treatment, and the difference was statistically significant (P<0.05), as shown in Table 2.

[0072] Table 2 Comparison of ODI index between the two groups of patients before and after treatment %

[0073]

[0074] Note: Compared with the group before treatment, *P<0.05, compared with the control group after treatment, △P<0.05.

[0075] As shown in Table 2, the Bushen Huoxue recipe can significantly improve the functional activity status of patients with lumbar disc herniation.

[0076] (3) JOA scores of patients in the two groups

[0077] There was no significant difference in the JOA scores between the two groups before treatment (P>0.05). After treatment, the JOA scores of the two groups were significantly increased compared with those before treatment, and the difference was statistically significant (P<0.05). After treatment, the JOA score of the intervention group was higher than that of the control group, and the difference was statistically significant (P<0.05). See Table 3 for details.

[0078] Table 3 Comparison of JOA scores between the two groups before and after treatment point

[0079]

[0080] Note: Compared with the group before treatment, *P<0.05, compared with the control group after treatment, △P<0.05.

[0081] As shown in Table 3, the Bushen Huoxue recipe can significantly improve the lumbar movement disorder in patients with lumbar disc herniation.

[0082] Case 1: Wang Moumou, female, 64 years old, from Anhui; time: February 2024, she was diagnosed with lumbar disc herniation (L5-S1) due to low back pain accompanied by radiating pain in the left lower limb. Indicators at the time of admission: VAS score of 7 points, lumbar JOA score of 11 points; after admission, she took the decoction preparation of Example 4 of the present invention, once in the morning and evening, warm, and after 2 weeks of intervention, the VAS score was 2 points and the lumbar JOA score was 24 points, proving that the Chinese medicine preparation of the present invention is effective.

[0083] Case 2: Zhang, male, 45 years old, from Hefei, Anhui; Time: September 2022, due to low back pain accompanied by numbness and pain in the right lower limb, after physical examination and complete magnetic resonance examination, lumbar disc herniation (L4-5) was diagnosed, and the index at admission was: VAS score 6 points, lumbar JOA score 10 points; after admission, the decoction preparation of Example 4 of the present invention was taken once in the morning and evening, warm, and after 2 weeks of intervention, the VAS score was 2 points and the lumbar JOA score was 23 points, proving that the Chinese medicine preparation of the present invention is effective. And during the two weeks of hospitalization, no abnormalities were found in the three reexaminations of blood routine and liver and kidney function, indicating the safety of this Chinese medicine preparation.

[0084] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A composition for treating lumbar disc herniation, characterized in that: The preparations shown include Eucommia ulmoides, Angelica dahurica, Ligusticum chuanxiong, Achyranthes bidentata, Salvia miltiorrhiza, Viscum album, frankincense, myrrh, Angelica dahurica, and Curcuma longa.

2. A composition for treating lumbar disc herniation according to claim 1, characterized in that: The preparation comprises the following raw materials: 5-15 parts of Eucommia ulmoides, 10-20 parts of Angelica sinensis, 5-15 parts of Ligusticum chuanxiong, 10-20 parts of Achyranthes bidentata, 5-15 parts of Salvia miltiorrhiza, 10-20 parts of Viscum album, 3-10 parts of frankincense, 3-10 parts of myrrh, 5-15 parts of Angelica dahurica and 5-15 parts of Curcuma longa.

3. A composition for treating lumbar disc herniation according to claim 1, characterized in that: The preparation comprises the following raw materials: 10 parts of Eucommia ulmoides, 15 parts of Angelica dahurica, 12 parts of Angelica sinensis, 10 parts of Ligusticum chuanxiong, 12 parts of Achyranthes bidentata, 10 parts of Salvia miltiorrhiza, 12 parts of Viscum album, 6 parts of frankincense, 6 parts of myrrh, 10 parts of Angelica dahurica and 10 parts of Curcuma longa.

4. A Chinese medicinal compound preparation for treating lumbar disc herniation, characterized in that: The invention comprises the Chinese medicine composition as claimed in any one of claims 1 to 3 and a pharmaceutically acceptable carrier or diluent.

5. A Chinese medicinal compound preparation for treating lumbar disc herniation according to claim 4, characterized in that: The Chinese medicine compound preparation is in the form of granules, tablets, capsules, pills, decoctions and syrups.

6. A Chinese medicinal compound preparation for treating lumbar disc herniation according to claim 5, characterized in that: The pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of a filler, a binder, a disintegrant, a lubricant, a surfactant or a flavoring agent.

7. A Chinese medicinal compound preparation for treating lumbar disc herniation according to claim 6, characterized in that: The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose.

8. A Chinese medicinal compound preparation for treating lumbar disc herniation according to claim 7, characterized in that: The adhesive is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone.

Images