Combination therapy for treating cancer

By using a combination therapy of antibody-drug conjugate (ADC) and bispecific binding protein, the problem of major side effects in existing cancer treatment methods is solved, and the efficient killing of cancer cells and the synergistic effect of the immune system is achieved, which improves the treatment efficiency and reduces the side effects.

CN119654347APending Publication Date: 2025-03-18IMMUNE MEDICAL LLC
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Patent Information

Application Number
CN202380057287.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-07-28
Filing Date
2023-07-27
Publication Date
2025-03-18

AI Technical Summary

Technical Problem

Existing cancer treatments such as surgery, radiation therapy and chemotherapy often lead to undesirable side effects and urgently demand innovative and less harmful treatments for cancer cells.

Method used

Using an antibody-drug conjugate (ADC) and a bispecific binding protein, ADCs contain antibodies, cleavable linkers and cytotoxic agents that bind to the B7-H4 polypeptide, while the bispecific binding protein has a first binding domain specifically bound to PD-1.

Benefits of technology

By directly delivering cytotoxic agents to cancer cells, it reduces damage to healthy cells, improves treatment efficiency and reduces side effects, and at the same time, it enhances its attack ability against cancer cells by regulating the immune system.

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Abstract

Provided herein are methods of treating cancer in a human subject comprising administering to the subject: i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker, and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor. Also provided herein are kits comprising i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker, and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor.
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