Compositions for use as dentin substitutes

By using uncrosslinked and undenatured collagen particles, bionic hydroxyapatite or amorphous calcium phosphate compositions, the problem of difficulty in repairing caries dentin in the prior art is solved, and the effect of effectively repairing demineralized dentin after caries is formed is achieved.

CN119677490APending Publication Date: 2025-03-21UNIVERSITY OF GENEVA +2
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Patent Information

Application Number
CN202380041752.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-03-23
Filing Date
2023-03-23
Publication Date
2025-03-21

AI Technical Summary

Technical Problem

The prior art is difficult to effectively repair dentin caries, especially after the formation of caries, traditional materials need to be dried before use, resulting in collagen denaturation and lack of liquid crystal tissue.

Method used

Compositions containing uncrosslinked and undenatured collagen particles, bionic hydroxyapatite or amorphous calcium phosphate, and physiologically compatible aqueous solvents are used for the repair and regeneration of dentin. The composition can form a bionic structure by self-assembly after injection or implantation as a scaffold for dentin repair.

Benefits of technology

It realizes effective repair of demineralized dentin after the formation of caries, and through the formation of a bionic structure and good combination with dentin, the mechanical integrity of the teeth and the effect of caries prevention are enhanced.

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Abstract

The present invention relates to a composition for dentin repair comprising ossein microparticles, biomimetic hydroxyapatite or a biomimetic hydroxyapatite precursor, and a physiologically compatible aqueous solvent, said ossein microparticles comprising more than 90% by weight of ossein.
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