Anti-FGF23 antibodies or fragments thereof
By replacing amino acid residues at specific positions in the VH of the antibody, the problem of easy decomposition of antibodies at low pH is solved, and its stability is significantly improved.
CN119677855APending Publication Date: 2025-03-21KYOWA HAKKO KIRIN CO LTD
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Patent Information
- Application Number
- CN202380058877.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2022-10-12
- Filing Date
- 2023-08-09
- Publication Date
- 2025-03-21
AI Technical Summary
Technical Problem
Existing anti-human FGF23 antibodies are less stable and easily decomposed at low pH, especially caused by cleavage between D at position 99 and I at position 100 in the amino acid sequence of the heavy chain variable region of the antibody.
Method used
The stability of the antibody at low pH is improved by substituting the amino acid residue at position 100 or position 105 in the VH of the antibody, for example, by replacing it with an alanine residue or a tyrosine residue.
Benefits of technology
The decomposition inhibition of the antibody at low pH was achieved, and its stability was significantly improved.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention pertains to: an antibody that binds to FGF23, said antibody comprising a heavy chain variable region (hereinafter referred to as VH) having an amino acid sequence represented by SEQ ID NO: 1 and a light chain variable region (hereinafter referred to as VL) having an amino acid sequence represented by SEQ ID NO: 2; at least the amino acid residue at position 100th or the amino acid residue at position 105th in the amino acid sequence represented by SEQ ID NO: 1 in VH is substituted with another amino acid residue.
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