Ergothioneine for alleviating and preventing age-related lens degeneration

By administering ergothioneine or its derivative to the subject, the chronic reactive oxygen species in the lens cells or the Nrf2 antioxidant gene was activated, the age-related lens degeneration problem was solved, and the turbidity in the lens was significantly improved, and effective relief and prevention effects were achieved.

CN119679149APending Publication Date: 2025-03-25NANJING NUTRABUILDING BIO TECH CO LTD
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Patent Information

Application Number
CN202411885880.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2023-12-26
Filing Date
2024-12-20
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

With the global aging, age-related lens degeneration has become increasingly common, leading to visual impairment and irreversible blindness, and existing treatments have problems with complications and unsatisfactory results.

Method used

Chronic reactive oxygen species in cells or activate Nrf2-mediated antioxidant genes to protect the lens from oxidative damage by administering ergothionine or its physiologically acceptable salts, acids, esters, polymers or derivatives to a subject in need thereof.

Benefits of technology

Ergothio significantly reduces the chronic reactive oxygen level in lens epithelial cells, increases Nrf2 expression, effectively alleviates and prevents age-related lens degeneration, and improves lens turbidity.

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Abstract

The present invention provides methods, compositions (e.g., eye drops or eye ointment compositions or food or supplement) and uses for alleviating and preventing age-related lens degeneration in a subject, comprising administering to a subject in need thereof an effective amount of ergothioneine or a physiologically acceptable salt, acid, ester, polymer, analog or derivative thereof.
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