Microfluidic device as well as operation method, application and equipment thereof

By designing a microfluidic device including chip assembly and auxiliary fixture, directly connecting the microchannel between the liquid inlet and the chip assembly, the problems of easy leakage, damage and complicated connection of microfluidic chips in the prior art are solved, and higher preparation efficiency and accuracy are achieved.

CN119680658AActive Publication Date: 2025-03-25SHANGHAI PENGZAN BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411785538.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-06
Publication Date
2025-03-25
Estimated Expiration
2044-12-06

AI Technical Summary

Technical Problem

The existing microfluidic chips need to frequently replace samples during operation, resulting in the chip being prone to liquid leakage and damage, and the connection process is cumbersome, affecting accuracy and reuse rate.

Method used

A microfluidic control device is designed, including a chip assembly and an auxiliary fixture. It encloses the slots of the liquid inlet layer plate to form a clamping space, directly connects the microchannels of the liquid inlet port and the chip assembly, cancels the intermediate connection components, and simplifies the operation process.

Benefits of technology

It simplifies the operation process, reduces the complexity of sample replacement, reduces dead volume, improves preparation efficiency and accuracy, and extends the service life of the chip.

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Abstract

The invention provides a micro-fluidic device and an operation method, application and equipment thereof, the micro-fluidic device is composed of a chip assembly and an auxiliary clamp, during operation, a first liquid inlet layer plate, a second liquid inlet layer plate and a liquid outlet layer plate are combined with each other, and clamping grooves in the three layer plates define a clamping area specially used for fixing the chip assembly along with the first liquid inlet layer plate, the second liquid inlet layer plate and the liquid outlet layer plate. According to the preparation requirements of nano or micron particles, the first chip or the second chip with the micro-channel of the corresponding size is replaced, so that different preparation requirements can be met, and the flexibility is high. The liquid inlet on the liquid inlet layer plate is directly butted with the micro-channel of the chip assembly, and a container filled with a double-phase solution can be directly inserted into the liquid inlet, so that the sample injection is smoothly completed. According to the design, a middle connecting part in a conventional device is omitted, the operation steps are greatly simplified, the dead volume of the device is reduced, and therefore the preparation efficiency and accuracy are improved.
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