Synthesis method of Iguratimod intermediate impurity and application of impurity

By using 2-nitro-4-methoxyphenol as raw material and carrying out a series of specific chemical reactions, the high-purity Alamod intermediate impurities were successfully prepared, which solved the preparation problems in the prior art and provided efficient quality control methods.

CN119684169APending Publication Date: 2025-03-25CHANGZHOU JIADE MEDICAL TECH CO LTD
0 Cites 0 Cited by

Patent Information

Application Number
CN202411857080.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-17
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The prior art is difficult to efficiently prepare impurities of the Ailamod intermediate, which affects the purity and quality control of the Ailamod intermediate.

Method used

Using 2-nitro-4-methoxyphenol as raw material, the target product N-(2-(4-(2-aminoacetyl)phenoxy)-5-methoxyphenyl)methanesulfonamide hydrochloride was successfully prepared through condensation reaction, reduction reaction, methanesulfonylation reaction, reduction reaction, condensation reaction and deprotection reaction.

Benefits of technology

It realizes the efficient preparation of impurities of Alamod intermediate, provides high-purity impurity reference products, supports the quality control of Alamod intermediate, and has mild process conditions, low equipment requirements, and is economical and practical.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a synthesis method of an iguratimod intermediate impurity and application of the impurity, and relates to the technical field of chemical synthesis. According to the synthetic method of the Iguratimod intermediate impurity, 2-nitro-4-methoxyphenol is used as a raw material and is sequentially subjected to a condensation reaction, a reduction reaction, a methylsulfonylation reaction, a reduction reaction, a condensation reaction and a deprotection reaction, and the Iguratimod intermediate impurity is obtained. The target product N-(2-(4-(2-amino acetyl) phenoxy)-5-methoxy phenyl) methanesulfonamide hydrochloride with high purity and correct structure can be obtained; the used raw materials are commercially available and easy to obtain, the reaction conditions of all the reaction steps are mild, the requirement for experimental equipment is not high, the application and implementation feasibility is high, and the economical efficiency is good. According to the application of the iguratimod intermediate impurity synthesized by the synthesis method provided by the invention in preparation of the iguratimod intermediate impurity reference substance, the qualified, cheap and easily available impurity reference substance is expected to be provided for quality control of the iguratimod intermediate.
Need to check novelty before this filing date? Find Prior Art