TREM-1 protein-targeted polypeptide and radioactive tracer derived from TREM-1 protein-targeted polypeptide
By developing a polypeptide NOTA-C-IPB-YIT targeting the TREM-1 protein and labeling it as a radiotracer [68Ga]Ga-NOTA-C-IPB-YIT, the problem of difficult to identify and diagnose TREM-1 protein high-expression tumors in the prior art is solved, and efficient imaging and diagnosis of TREM-1 positive tumors are achieved.
CN119684402AActive Publication Date: 2025-03-25SHANDONG UNIV
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Patent Information
- Application Number
- CN202510213167.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-26
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2045-02-26
AI Technical Summary
Technical Problem
The difficulty in the prior art to effectively identify and diagnose tumors with high expression of TREM-1 protein, especially in the tumor microenvironment, has limited traditional methods in recognition and diagnosis.
Method used
A polypeptide NOTA-C-IPB-YIT targeting the TREM-1 protein was developed, and the radiotracer [68Ga]Ga-NOTA-C-IPB-YIT was constructed through 68Ga labeling to achieve efficient identification and diagnosis of TREM-1 protein.
Benefits of technology
Through in vitro and in vivo experiments, the good affinity and stability of radiotracer [68Ga]Ga-NOTA-C-IPB-YIT for TREM-1-positive tumors was demonstrated, and it can be effectively used for imaging and efficacy monitoring of TREM-1 protein-expressing tumors.
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Abstract
The invention relates to the technical field of biomedicine, in particular to polypeptide targeting TREM-1 protein and a radioactive tracer derived from the polypeptide. The invention provides polypeptide NOTA-C-IPB-YIT for targeting a TREM-1 positive tumor, and the polypeptide NOTA-C-IPB-YIT is subjected to < 68 > Ga labeling, so that a radioactive tracer [< 68 > Ga]-NOTA-C-IPB-YIT for targeting a TREM-1 protein is constructed. Through in-vitro radiochemical property research and in-vivo stability research, the radioactive tracer [68Ga] Ga-NOTA-C-IPB-YIT is found to be high in stability and hydrophilic; through cell uptake research and receptor binding force research, it is found that the radioactive tracer agent [68Ga] Ga-NOTA-C-IPB-YIT has good affinity to TREM-1 protein expressed by U87MG cells; the tumor imaging effect of the radioactive tracer [68Ga] Ga-NOTA-C-IPB-YIT is investigated through small animal PET / CT, and it is found that the radioactive tracer [68Ga] Ga-NOTA-C-IPB-YIT can be used for in-vivo imaging of TREM-1 positive tumors.
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