Nanocomposite material capable of adjusting synaptic plasticity and preparation method thereof

By introducing polyamino acids with glutamate receptor inhibitors into nanocomposites, the inadequate targeting and biocompatibility of synaptic regulation in the prior art is solved, and effective relief of chronic oral pain is achieved.

CN119684613APending Publication Date: 2025-03-25SOUTHERN MEDICAL UNIV STOMATOLOGICAL HOSPITAL (GUANGDONG STOMATOLOGICAL HOSPITAL GUANGDONG DENTAL DISEASE PREVENTION & TREATMENT GUIDANCE CENT)
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Patent Information

Application Number
CN202411877762.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-19
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The prior art has problems with insufficient targeting and biocompatibility in regulating synaptic plasticity and relieving chronic oral pain.

Method used

By forming copolymers with polylactic acid and polyamic acids, nanocomposites are prepared, and polyamic acids are grafted and modified, and side chain groups with glutamate receptor inhibitors are added to accurately interfere with synaptic transition sensitization and control the abnormal manifestations of long-term synaptic enhancement in the central nervous system.

Benefits of technology

Accurate regulation of synapses is achieved, which weakens the excessive propagation of pain signals and relieves chronic oral pain.

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Abstract

The invention discloses a nano composite material capable of adjusting synaptic plasticity and a preparation method thereof, and belongs to the technical field of nano materials. Polylactic acid and polyamino acid form a copolymer, the nano composite material is formed, the polyamino acid is subjected to graft modification, and a glutamic acid receptor inhibitor passes through the polyamino acid terminal, so that the synaptic plasticity can be adjusted. By regulating and controlling the synapses, the transient sensitization of the synapses is accurately intervened, and the abnormal expression of long-term enhancement of the synapses of the central nervous system is controlled, so that the chronic oral pain is relieved.
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