Potential SABRE enhanced P-31-containing compound screening method based on P-31 CEST

By using the P-31CEST method to screen the reversible binding ability of P-31-containing compounds under nonventilated conditions, the problems of low screening efficiency and poor measurement accuracy in the prior art are solved, and a fast and repeatable screening process is achieved, providing technical support for SABRE to enhance P-31 signal.

CN119688765AActive Publication Date: 2025-03-25INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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Patent Information

Application Number
CN202411987967.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-31
Publication Date
2025-03-25
Estimated Expiration
2044-12-31

AI Technical Summary

Technical Problem

The prior art is inefficient and the measurement accuracy and repeatability are affected when screening for enhanced P-31-containing compounds by SABRE, especially due to the problem of solvent volume reduction caused by the ventilation process.

Method used

Using a P-31CEST-based method, in the absence of ventilation, the P-31CEST Z spectrum was used to determine whether the P-31-containing compound to be tested is reversibly bound to the catalyst, thereby screening for potential SABRE-enhanced compounds.

Benefits of technology

It realizes rapid, simple and reproducible screening of P-31-containing compounds that can reversibly bind to the catalyst, improving the accuracy and reproducibility of the test, and providing technical support for SABRE to enhance P-31 signal and its potential applications.

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Abstract

The invention provides a potential SABRE enhanced P-31-containing compound screening method based on P-31CEST. The method comprises the following steps: (1) preparing a to-be-detected solution composed of a to-be-detected compound, a catalyst and a solvent; (2) carrying out hydrogen spectrum and phosphorus spectrum magnetic resonance detection on the solution to be detected, and determining a P-31 magnetic resonance signal position of a free compound to be detected; (3) selecting a P-31CEST pulse sequence, setting experimental parameters, and collecting a CEST Z spectrum of the solution to be detected; (4) calculating the asymmetric magnetization transfer rate spectrum of the solution to be detected by using the CEST Z spectrum acquired in the step (2); and (5) analyzing the CEST Z spectrum acquired in the step (2) by using a quantitative method to obtain exchangeable signal quantitative information, determining whether the compound to be detected is combined with the catalyst or not, and screening the potential SABRE-enhanced compound to be detected. According to the method, the P-31-containing compound capable of being reversibly combined with the catalyst can be simply, rapidly and repeatedly screened out, and technical support is provided for SABRE enhanced P-31-containing compound condition selection to be detected and potential application of the SABRE enhanced P-31-containing compound.
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