Application of cellulose-based material as biological cryoprotectant

By using cellulose-based materials as biorefrigeration protectors, the problems of existing antifreeze agents' biotoxicity and high concentration requirements are solved, low concentration and high efficiency ice crystal inhibition effect are achieved, and the survival rate and activity of cells and vaccines after freezing are improved.

CN119699310AActive Publication Date: 2025-03-28BEIJING INST OF TECH +1
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Patent Information

Application Number
CN202411913715.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-24
Publication Date
2025-03-28
Estimated Expiration
2044-12-24

AI Technical Summary

Technical Problem

In the existing bio-freezing technology, commonly used antifreeze agents such as dimethyl sulfoxide and glycerol are biotoxic and require high concentrations to effectively inhibit ice crystal growth and recrystallization. The preparation is complex, costly and poor stability, which limits its application in the industrial field.

Method used

Cellulose-based materials are used as biorefrost protection agents, and by adjusting their average polymerization degree and surface charge, combined with different chemical groups to modify them, a cellulose-based antifreeze with good biocompatibility and low concentration and high-efficiency antifreeze effect is prepared.

Benefits of technology

Cellulose-based antifreeze can modify the morphology of ice crystals, inhibit the growth and recrystallization of ice crystals, significantly improve the survival rate of cells after frozen storage, improve the activity and status of vaccines and organs after frozen storage, and also have the characteristics of simple, rapid and economical preparation.

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Abstract

The invention discloses application of a cellulose-based material as a biological cryoprotectant, and relates to the technical field of materials. According to the invention, a cellulose-based material with an average polymerization degree range of 2-1000 and surface charges is used as a biological cryoprotectant, so that the cellulose-based material can be combined on an ice crystal surface to inhibit the growth of the crystal surface and the movement of water between crystal boundaries, thereby realizing the effects of modifying the ice crystal morphology and inhibiting the growth and recrystallization of the ice crystal, realizing an efficient anti-freezing effect at low concentration, and being suitable for the field of ice freezing. The method has huge potential in the fields of cryopreservation of cells, vaccines and organs and the like.
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