Bone metastasis tumor diagnosis and treatment integrated carbon-based nano platform as well as preparation method and application thereof

By developing a multimodal imaging capability integrated carbon-based nano-platform platform for bone metastasis diagnosis and treatment, using watermelon derivatives to synthesize boron/nitrogen/manganese co-doped carbon dots and outer coated with hyaluronic acid and alendronate sodium, the radiation, nonspecific and high cost problems in the early diagnosis and treatment of bone metastasis tumors are solved, and efficient and precise treatment of bone metastasis tumors is achieved.

CN119701019APending Publication Date: 2025-03-28SHANXI PROVINCIAL PEOPLES HOSPITAL (AFFILIATED HOSPITAL OF SHANXI HEALTH VOCATIONAL COLLEGE)
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Patent Information

Application Number
CN202411870788.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-18
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The prior art has problems of radiation, nonspecificity and high cost in the early accurate diagnosis and treatment of bone metastases, and conventional chemotherapy is difficult to effectively inhibit the growth of bone metastases.

Method used

A carbon-based nano-platform platform for diagnosis and treatment of bone metastases with multimodal imaging capabilities was developed. Through watermelon derivatives as carbon sources, boron/nitrogen/manganese co-doped carbon dots were synthesized by a one-pot hydrothermal method, and hyaluronic acid and alendronate sodium were coated to achieve NIR-IIFL/PA/AMRI imaging, phototherapy and chemokinetic therapy.

Benefits of technology

This nanoplatform has the ability to actively and passively target bone metastases, and can perform synergistic anti-tumor and bone repair, achieve effective inhibition of bone metastases, and improve the accuracy and safety of treatment.

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Abstract

The invention aims to provide a bone metastasis tumor diagnosis and treatment integrated carbon-based nano-platform and a preparation method and application thereof, and belongs to the technical field of nano biomedical materials, the carbon-based nano-platform is B / N / Mn-CDs (at) HA / ALN, a watermelon derivative is used as a carbon source, boron / nitrogen / manganese co-doped carbon dots are synthesized by a one-pot hydrothermal method, hyaluronic acid is coated outside the carbon dots, and the carbon-based nano-platform is prepared. And modifying with alendronate sodium to obtain the alendronate. The diagnosis and treatment integrated carbon-based nano platform can be used for carrying out efficient phototherapy and chemical kinetics treatment on a bone metastatic tumor part under the guidance of NIR-II fluorescence / photoacoustic / activated nuclear magnetic imaging so as to effectively kill tumor cells, and further activating a cGAS-STING pathway to up-regulate INF-beta expression so as to achieve the effect of promoting bone repair.
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