Gelatin sponge particle capable of carrying medicine and slowly releasing and preparation method thereof
By grafting anionic functional groups and crosslinking agents in gelatin sponge particles, gelatin sponge particles with high water absorption and sustained release performance are solved, and the problem of poor drug release in existing embolizers in the tumor site is achieved, and the feasibility of targeted drug administration and multiple treatments is achieved.
Patent Information
- Application Number
- CN202510238166.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-28
- Publication Date
- 2025-03-28
AI Technical Summary
The existing granule embolization agents cannot effectively release drugs slowly in the tumor site during interventional treatment of liver cancer, resulting in poor treatment effect. At the same time, their water absorption rate is low, increasing the complexity of treatment and the amount of drug use.
Using drug-loaded sustained release gelatin sponge particles, gelatin molecules are polymerized with compounds with anionic functional groups and crosslinked with crosslinking agent to form gelatin sponge particles with high water absorption and sustained release properties.
Targeted drug administration at the tumor site is achieved, the amount of drug used is reduced, the treatment effect is improved, and the biocompatibility and degradability is suitable for multiple treatments.