Tissue engineering tubular stent and manufacturing method thereof

By setting holes on the tubular support skeleton of the tissue-engineered vascular stent and performing low-temperature plasma treatment, combined with the three-layer structure of the hydrogel coating, the problems of difficulty in forming the stent and poor configuration retention ability are solved, and stronger mechanical properties and compressive resistance are achieved.

CN119701098AActive Publication Date: 2025-03-28BEIJING INST OF TECH +1
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Patent Information

Application Number
CN202510017419.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-06
Publication Date
2025-03-28
Estimated Expiration
2045-01-06

AI Technical Summary

Technical Problem

The existing tissue engineering vascular stents have difficulty forming, poor configuration retention ability and insufficient mechanical properties, which limit their application in tissue engineering technology.

Method used

By setting multiple holes on the tubular support frame and using low-temperature plasma etching and surface modification, combined with the three-layer structure of the hydrogel cladding, the tubular support frame is embedded to enhance its morphological retention and compressive resistance.

Benefits of technology

The morphological retention ability of the hydrogel coating and the compressive resistance of the inner and outer walls of the tube lumen are achieved, which reduces the possibility of body rejection reactions, and improves the ability of tissue-engineered vascular stents to withstand physiological activities after in vitro culture and implantation.

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Abstract

The invention relates to the technical field of tissue engineering scaffolds, in particular to a tissue engineering tubular scaffold and a manufacturing method thereof.The tissue engineering tubular scaffold comprises a tubular supporting framework, the wall of the tubular supporting framework is provided with a plurality of holes, and the tubular supporting framework is subjected to etching and surface modification through low-temperature plasma; the hydrogel coating layer comprises a hydrogel coating inner layer and a hydrogel coating outer layer which extend in the axial direction, the tubular supporting framework is arranged between the hydrogel coating inner layer and the hydrogel coating outer layer, and the hydrogel coating layer completely coats the tubular supporting framework; the tubular supporting framework is used for supporting the hydrogel coating inner layer and the hydrogel coating outer layer. By means of the arrangement, the tissue engineering tubular scaffold is beneficial to in-vitro culture of tubular tissue and meets the requirements for biological performance and mechanical performance after being implanted in vivo, and the problems that a hydrogel type 3D printing tissue engineering tubular scaffold is poor in shape keeping capacity, insufficient in mechanical performance and poor in bonding strength of different materials are solved.
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