End side microcarrier sorting system for improving NanoDet based on knowledge distillation

By using the NanoDet model and Kalman filtering algorithm based on knowledge distillation on the end-side device, the problems of low accuracy and resource limitation in the microcarrier sorting process are solved, and efficient and accurate microcarrier detection and sorting are achieved, which is suitable for resource-constrained end-side platforms.

CN119702097AActive Publication Date: 2025-03-28UNIV OF SCI & TECH OF CHINA
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Patent Information

Application Number
CN202411782282.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-05
Publication Date
2025-03-28
Estimated Expiration
2044-12-05

AI Technical Summary

Technical Problem

The prior art has problems of low accuracy, time-consuming and cell damage in the microcarrier sorting process, especially on resource-constrained end-side platforms, which are difficult to achieve efficient and accurate microcarrier detection and sorting.

Method used

Using the NanoDet model based on knowledge distillation, combined with the microfluidic chip and Kalman filtering algorithm, label-free detection and selective extraction are achieved on the end-side device, improving the detection accuracy and sorting efficiency of the microcarrier.

Benefits of technology

It realizes efficient and precise detection and sorting of microcarriers containing cells on resource-constrained end-side platforms, reducing computational complexity and energy consumption, and improving the real-time and reliability of the system.

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Abstract

The invention relates to the technical field of automatic control of micro-fluidic chips, and discloses an end-side micro-carrier sorting system for improving NanoDet based on knowledge distillation, which comprises a micro-carrier generation module based on a micro-fluidic chip technology, controls fluid to form a micro-carrier containing cells through a flow focusing mode, and guides the micro-carrier to a processing channel; the real-time monitoring module uses a camera and a NanoDet model after knowledge distillation and compression to quickly identify whether the microcarrier contains a target microcarrier; the data processing unit compresses the NanoDet model by applying a knowledge distillation algorithm, so that the computing resource consumption and the energy consumption of the end side equipment are reduced; the miniaturized hardware system can process monitoring data in real time and control the sorting process of the microcarriers. The micro-carrier sorting, monitoring and automatic operation are integrated on the micro-fluidic chip, the flux of micro-carrier sorting is effectively improved, and meanwhile, the integration level and usability of the whole system are improved based on the end side deployment mode of the model.
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