Preparation method of noraadrenone hydrochloride
By using solid ammonia source and catalyst in the preparation of norepinephrine hydrochloride, the problems of impurities generation, slow reaction speed and low purity in the prior art are solved, and efficient, high-speed and high-purity preparation is achieved to meet the needs of industrial production.
CN119707720APending Publication Date: 2025-03-28BENGBU BBCA MEDICINE SCI DEV
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Patent Information
- Application Number
- CN202411678976.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-21
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
The existing preparation methods for norepinephrine hydrochloride have problems such as impurity generation, slow reaction speed and low purity, which are difficult to meet the needs of industrial production.
Method used
High-purity norepinephrine hydrochloride is prepared by controlling the reaction conditions such as temperature and time by using solid ammonium carbonate reactions with catalysts (such as iodides and quaternary ammonium salts) in organic solvents.
Benefits of technology
It reduces impurities generation, improves reaction speed and purity, provides a high-purity intermediate, laying the foundation for the preparation of heavy norepinephrine tartaric acid.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to a preparation method of noraadrenone hydrochloride, which comprises the following steps: in the presence of a catalyst, chloracetyl catechol and a solid ammonia source are subjected to a first reaction in an organic solvent, and the solid ammonia source is selected from ammonium carbonate and / or ammonium bicarbonate. The solid ammonia source such as ammonium carbonate is used as the ammonia source, the generation of impurities is reduced, the reaction speed is accelerated by using the catalyst, the reaction time is shortened, noradrenone hydrochloride with higher purity can be prepared, and an intermediate with higher purity is provided for preparing noradrenaline bitartrate.
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