Preparation method of glycin-14C
By hydrolyzing the 2-(benzylamino)acetonitrile-1-14C after reaction with benzylamine hydrochloride and labeled potassium cyanide, and obtaining 14C-labeled glycine through palladium hydrocarbon reaction, the problems of using highly toxic raw materials and complex processes in the existing glycine synthesis methods were solved, and efficient and safe preparation of glycine-14C was achieved, providing an important tool for biological and medical research.
Patent Information
- Application Number
- CN202411846077.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-16
- Publication Date
- 2025-03-28
AI Technical Summary
The existing glycine synthesis methods have problems such as using highly toxic raw materials, high process technology requirements, complex by-product treatment and low yield, making it difficult to achieve both safety, efficiency and cost.
After reacting benzylamine hydrochloride with labeled potassium cyanide, sodium hydroxide was hydrolyzed to synthesize 2-(benzylamino)acetonitrile-1-14C, and 14C-labeled glycine was obtained by palladium hydrocarbon hydrocarbon reaction, achieving efficient labeling of glycine.
This method is simple to operate, has few by-products, is easy to purify, and has a short time period. It can achieve high yield glycine-14C preparation. It is suitable for tracking the metabolic pathways of glycine in the body and the circulation of organisms. It has important biological and medical research value.