Method for preparing phenytoin sodium by one-pot method

The oxidation and cyclosynthesis reaction in polyethylene glycol 400 was carried out by a one-pot method, and sodium phenytoin was successfully prepared, solving the problems of high toxicity, long reaction time and low yield in the prior art, achieving an efficient and green preparation process.

CN119707824APending Publication Date: 2025-03-28四川文理学院
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Patent Information

Application Number
CN202411904761.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-23
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

There are problems such as high toxicity, long reaction time and low yield in the preparation process of phenytoin sodium.

Method used

By oxidizing reaction in polyethylene glycol 400, reaction solution A was obtained, and then urea and alkali solution were added to reaction solution A for cyclization reaction, reaction solution B was obtained, and water was added to reaction solution B and filtered, adjust the pH to acidity, precipitate phenytoin, and water and alkali solution were added thereto for salt-forming reaction, obtain sodium phenytoin.

Benefits of technology

It shortens the overall reaction time, improves the yield, avoids the pungent organic solvents and dehydration-prone oxidants used in traditional processes, is convenient to operate and conforms to the concept of green chemistry.

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Abstract

The invention provides a method for preparing phenytoin sodium through a one-pot method, and belongs to the technical field of medicine synthesis. The method for preparing phenytoin sodium by the one-pot method comprises the following steps: (1) adding benzoin and ferric nitrate nonahydrate into polyethylene glycol 400 for oxidation reaction to obtain a reaction solution A; (2) adding urea and alkali liquor into the reaction solution A, and carrying out cyclization reaction to obtain a reaction solution B; (3) adding water into the reaction solution B, filtering, adjusting the pH value of the filtrate to be acidic, and separating out phenytoin; and (4) adding water and alkali liquor into phenytoin, and carrying out salt forming reaction to obtain phenytoin sodium. By utilizing the method disclosed by the invention, the problems of high raw material toxicity, long reaction time and low yield in the existing phenytoin sodium preparation process can be solved; the whole reaction time is short, the yield is high, intermediate products do not need to be separated in the preparation process, operation is convenient and efficient, the green chemistry concept is met, and the method has great application and popularization value.
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