Method for synthesizing albendazole
By introducing a reduction reaction catalyzed by Bacillus megaly in the synthesis of albendazole, the problems of low yield and environmental pollution in the prior art are solved, and a higher yield and more environmentally friendly synthesis process is achieved.
CN119707831APending Publication Date: 2025-03-28HEBEI MEIHE PHARM CO LTD
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Patent Information
- Application Number
- CN202411917247.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-24
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
The existing albendazole synthesis methods lead to low environmental pollution and yield, and lack of green and environmentally friendly and efficient synthesis methods.
Method used
The yield of albendazole was successfully improved through nitration reaction, reduction reaction catalyzed by Bacillus megabyte, diazotization and substitution reaction and alkylation reaction.
Benefits of technology
It significantly improves the yield of albendazole, reduces environmental pollution, and provides a more green and environmentally friendly synthetic method.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of pharmacy, and provides a method for synthesizing albendazole, which comprises the following steps: carrying out nitration reaction on benzimidazole-2-methyl carbamate to obtain 5-nitrobenzimidazole-2-methyl carbamate, and carrying out reduction reaction on the 5-nitrobenzimidazole-2-methyl carbamate by using bacillus megaterium to obtain the albendazole. 5-aminobenzimidazole-2-methyl carbamate is obtained, then diazotization, substitution and alkylation reactions are carried out, and albendazole is obtained. According to the technical scheme, the problem of low yield of albendazole in the phase operation is solved.
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