Biphenyl piperidine hydrate single crystal, preparation method thereof and application of biphenyl piperidine hydrate single crystal in prevention and treatment of aging and neurodegenerative diseases
By using biphenylpiperidine (DL0410) hydrate single crystal, multi-target multi-path plays a role, solving the problem that existing anti-dementia drugs cannot completely cure Alzheimer's disease, and achieving a significant improvement of cognitive function and reducing intracerebral inflammation.
CN119707869APending Publication Date: 2025-03-28INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Patent Information
- Application Number
- CN202311279156.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-09-28
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
Existing anti-dementia drugs cannot completely cure Alzheimer's disease, and there are problems such as high preparation cost and slow onset of effect, making it difficult to widely use.
Method used
Biphenyl piperidine (DL0410) hydrate single crystal is used to exert anti-Alzheimer's disease effect through multi-target multi-pathways, including inhibiting cholinesterase activity, antioxidant, anti-inflammatory immunity, inhibiting Aβ amyloid aggregation, etc.
Benefits of technology
DL0410 significantly prolongs the lifespan of nematodes, improves cognitive dysfunction in 2VO rats, improves memory ability, reduces oxidative damage and inflammation in the brain, and protects nerve cell and mitochondrial functions.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the technical field of medicines, and discloses a biphenyl piperidine (DL0410) hydrate single crystal, namely (((1, 1 '-([1, 1'-biphenyl]-4, 4 '-diyl) bis (3-(piperidine-1-yl) propan-1-one) dihydrochloride)) hexahydrate single crystal, a preparation method thereof, a composition thereof, and application of medicines for preventing and treating senescence, vascular dementia and neurodegenerative diseases. Specifically, the invention discloses a biphenyl piperidine hydrate monocrystal state form existing in a saturated aqueous solution; a method for preparing a biphenyl piperidine hydrate single crystal; the application of the biphenyl piperidine hydrate single crystal substance in preparation of medicines for preventing and treating senescence, vascular dementia and neurodegenerative diseases can be remarkably prolonged by utilizing the biphenyl piperidine hydrate single crystal substance. # imgabs0 #
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