Lactobacillus paracasei and application thereof in preparation of products for improving oral health

By using C. paracetacci ProfMIC-143 to regulate and inhibit virulence gene expression and biofilm formation of oral pathogens, the problem of difficulty in effectively improving oral health in the prior art has been solved, and the multi-faceted inhibition of oral pathogens has been achieved, and the oral health status has been significantly improved.

CN119709461APending Publication Date: 2025-03-28廖梅香
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Patent Information

Application Number
CN202410971935.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-07-19
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The prior art is difficult to effectively regulate and inhibit the virulence gene expression and biofilm formation of pathogenic bacteria in the oral cavity, resulting in the occurrence of oral diseases such as caries and periodontal diseases.

Method used

Using ProfMIC-143, this strain can regulate the virulence gene expression of oral pathogens, inhibit the formation of bacteria-fungal complex biofilms, compete to bind fungal mycelium, agglutinate pathogens, and reduce the formation of oral bacterial biofilms.

Benefits of technology

It effectively reduces the virulence gene expression and biofilm formation rate of oral pathogens such as Streptococcus mutation and Candida leucorrhea, reduces the pathogenicity of the pathogen and improves oral health.

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Abstract

The invention belongs to the field of microorganisms, and provides a Lactobacillus paracasei ProfMIC-143 and application thereof in preparation of products for improving oral health, the Lactobacillus paracasei ProfMIC-143 has a preservation number of CCTCC NO: M 2024911, is preserved in China Center for Type Culture Collection on May 13, 2024, and is derived from the oral cavity of healthy adults, and the inventor finds that the Lactobacillus paracasei ProfMIC-143 has a preservation number of CCTCC NO: M 2024911, and the preservation number of the Lactobacillus paracasei ProfMIC-143 is CCTCC NO: M 2024911. The strain has the functions of regulating oral pathogen virulence genes, inhibiting oral pathogen bacteria-fungus composite biofilms, competitively combining oral pathogen fungus hyphae, agglutinating oral pathogens and reducing oral flora biofilms, and can be used for preparing products for reducing oral pathogen pathogenicity, products for improving oral health and the like.
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