Preparation method and application of photoelectrochemical-surface enhanced Raman spectrum sensor

The photoelectrochemical-surface-enhanced Raman spectroscopy sensor constructed using a bifunctional nanoprobe based on a porphyrin-based metal organic frame and a silver-wrapped gold nanodumbbell nanostructure, the problem of insufficient signal enhancement mechanism and poor stability in the prior art was solved, and a high sensitivity and high accuracy penicillin detection was achieved.

CN119715495AActive Publication Date: 2025-03-28JIANGSU UNIV
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Patent Information

Application Number
CN202411925797.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-03-28
Estimated Expiration
2044-12-25

AI Technical Summary

Technical Problem

Existing photoelectrochemical and surface-enhanced Raman spectroscopy sensors face the problems of insufficient signal enhancement mechanism and poor stability when detecting penicillin, and cannot provide efficient photoelectric and Raman signals at the same time, limiting the accuracy and information of the detection.

Method used

A photoelectrochemical-surface enhanced Raman spectroscopy (PEC-SERS) sensor is constructed using a dual-function nanoprobe based on a porphyrin-based metal organic frame, using the excellent light absorption capacity and Raman scattering characteristics of Zr-MOF, combined with silver-wrapped gold nanodumbbell nanostructures as a reinforcement substrate.

Benefits of technology

It realizes the generation of obvious photoelectrochemical and surface-enhanced Raman signals under low power excitation, improves the sensitivity and accuracy of penicillin detection, and has better signal stability.

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Abstract

The invention belongs to the technical field of analytical chemistry and biosensing, and relates to a preparation method and application of a photoelectrochemical-surface enhanced Raman spectrum sensor. The sensor can generate obvious PEC and SERS signals at the same time under low-power 532nm Raman excitation light by utilizing the excellent light absorption capability and Raman scattering characteristic of Zr-MOF. And compared with porphyrin molecules, the Zr-MOF has better Raman signal stability. Preparing AuNDs (at) AgNPs as a dual-function enhanced substrate to enhance Zr-MOF photoelectric and Raman signals; an aptamer is connected with a difunctional nanoprobe Zr-MOF and AuNDs (at) AgNPs to construct a photoelectrochemical-surface enhanced Raman spectrum sensor, double signals are simultaneously acquired on the same electrode and are mutually referenced, high-sensitivity and high-precision detection on the patulin is realized, and the detection linear range is 1 pg mL <-1 >-100 ng mL <-1 >.
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