Chitosan-modified folic acid-targeted LDHs@CBD drug-loaded nanoparticles and their preparation method and application

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By inserting cannabidiol into layered dihydroxides and coating them with folic acid coupling and chitosan, targeted LDHs@CBD drug-loaded nanoparticles are formed, and the problems of poor selectivity and strong toxicity of breast cancer treatment drugs in the prior art are solved, achieving a more efficient and targeted therapeutic effect.

CN119745835APending Publication Date: 2025-04-04SHENZHEN ZHONGJIA BIOMEDICAL TECH CO LTD

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Patent Information

Application Number: CN202411932521.0
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2024-12-26
Publication Date: 2025-04-04

Application Information

Patent Timeline

26 Dec 2024

Application

CN202411932521.0

04 Apr 2025

Publication

CN119745835A

IPC: A61K9/52; A61K31/05; A61K47/36; A61K47/02; A61K47/54; A61P35/00; A61P15/14

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Application Domain

Hydroxy compound active ingredients Inorganic non-active ingredients

Technology Topics

Drug release rate Folate targeting

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AI Technical Summary

Technical Problem

The chemotherapeutic drugs used in the treatment of breast cancer have poor selectivity, strong toxicity and limited efficacy, especially triple-negative breast cancer lacks effective molecular targets, resulting in insufficient therapeutic effect.

Method used

Cannabidiol (CBD) was inserted into layered double hydroxides (LDHs) by ball milling, and coated by folic acid coupling and chitosan to form targeted LDHs@CBD drug-loaded nanoparticles, improving the solubility, targeting and sustained release functions of the drug.

Benefits of technology

It improves the bioavailability and efficacy of CBD, extends the time of action of drugs in the body, enhances the targeting effect on triple-negative breast cancer cells, and reduces the toxic side effects on healthy cells.

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Abstract

The present invention belongs to the field of medical technology, and specifically relates to chitosan-modified folic acid-targeted LDHs@CBD drug-loaded nanoparticles and their preparation methods and applications. In order to improve the solubility, bioavailability, targeting and sustained-release effect of CBD drugs, the present invention first uses a ball milling method to effectively intercalate CBD into layered double hydroxides (LDHs), and couples the carrier through folic acid to enhance the solubility, targeting and sustained-release function of the drug. At the same time, chitosan is used as a coating material to coat the surface of the LDHs@CBD complex, thereby effectively controlling the release rate of the drug and enhancing the stability and bioavailability of the drug in vivo. Therefore, the LDHs@CBD drug-loaded system provided by the present invention combines the targeting effect of folic acid and the coating effect of chitosan, and has a wide range of application prospects in tumor-targeted drug delivery, especially in the treatment of tumors such as breast cancer.

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