Application of polypeptide composition and composition for treating senescence-related skin diseases

By using polypeptide compositions such as acetyl hexapeptide-8, acetyl octapeptide-3, acetyl heptide-4, palmitoyl tripeptide-5, acetyl tetrapeptide-2, and combining cyclodextrin derivatives and cell-permeable peptides, the problem of the difficulty of polypeptide through the skin level in the prior art is solved, and efficient penetration and long-term anti-aging effects are achieved, and it is particularly suitable for the treatment of aging-related skin diseases such as atopic dermatitis.

CN119746027AInactive Publication Date: 2025-04-04SHANDONG JITAI BIOTECH CO LTD
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Patent Information

Application Number
CN202510038954.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-10
Publication Date
2025-04-04
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art is difficult to effectively pass through the skin layer and achieve the dermis to achieve anti-aging effects, and the existing polypeptide compositions are insufficient in permeability and stability, making it difficult to effectively treat aging-related skin diseases in the long run.

Method used

A polypeptide composition consisting of acetyl hexapeptide-8, acetyl octapeptide-3, acetyl heptide-4, palmitoyl tripeptide-5, and acetyl tetrapeptide-2 was used, and the skin permeability and stability of the complex peptide were improved by adding cyclodextrin derivatives and permeation promoters.

Benefits of technology

The efficient penetration of the polypeptide composition into the dermis is achieved, which significantly improves the anti-aging, anti-inflammatory, anti-itching and anti-free radical effects, especially in the treatment of atopic dermatitis, and has long-term anti-aging effects.

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Abstract

According to the composition for treating senescence-related skin diseases provided by the invention, through a specific polypeptide composite synergistic effect, compared with the use of single peptides, the polypeptide composition is based on the action mechanism of skin senescence, the action mechanism of each polypeptide is combined, and the polypeptides are scientifically and reasonably matched, so that the maximization of the efficacy of the polypeptides is realized; the anti-inflammatory, antibacterial and anti-free radical effects are remarkable, aging-related skin diseases are effectively treated, and particularly the effect of treating atopic dermatitis is remarkable; the polypeptide composition comprehensively solves the problem of skin aging, and the anti-aging function is remarkably improved; in addition, the composite peptide clathrate with the penetration enhancer is added, so that the skin permeability of the polypeptide is greatly improved, and the penetration rate and the penetration amount are remarkably improved; when a small amount of polypeptide is used, the resident dosage of the skin is remarkably increased, and finally, the long-acting anti-aging effect is realized, so that the health and beauty of the skin are guaranteed.
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