Preparation method of reversible covalent bond controlled slow-release bio-based nano-drug

By oxidizing and lateral linking branches on cellulose nanocrystals, a bio-based nanodrug carrier that controls sustained release is formed with reversible covalent bonds, which solves the problems of unstable drug release and poor carrier functional modification in the prior art, and achieves efficient drug targeting and sustained release therapeutic effects.

CN119746092APending Publication Date: 2025-04-04NANJING FORESTRY UNIV
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Patent Information

Application Number
CN202510020542.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-07
Publication Date
2025-04-04

AI Technical Summary

Technical Problem

In the prior art, it is difficult for nanodrug carriers to achieve sustainable and stable drug release in the body, resulting in poor therapeutic effects, complex synthesis process, high cost and poor functional modification.

Method used

Dialdehyde cellulose nanoparticles were obtained by oxidizing cellulose nanoparticles, and the methoxy polyethylene glycol side chain and amino-containing anti-cancer drugs were grafted through Schiff base reaction to form a bio-based nanodrug carrier that controls sustained release by reversible covalent bonds.

Benefits of technology

The drug is sustained release with high drug loading, high salt tolerance and low cytotoxicity. The drug can be responsively released under acidic conditions, which is suitable for targeted treatment of tumor sites.

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Abstract

The invention discloses a preparation method of a reversible covalent bond controlled slow-release bio-based nano-drug carrier. The preparation method comprises the following steps: firstly, oxidizing cellulose nanocrystals to obtain dialdehyde cellulose nanoparticles; reacting the dialdehyde cellulose nanoparticles with methoxy polyethylene glycol amine and sodium cyanoborohydride respectively to obtain cellulose nanoparticles grafted with a polyethylene glycol side chain; and finally, further covalently binding an amino-containing anti-cancer drug and the cellulose nanoparticles grafted with the methoxy polyethylene glycol side chain through a Schiff base reaction to obtain the reversible covalent bond controlled slow-release bio-based nano-drug carrier based on the Schiff base structure. The reversible covalent bond controlled slow-release bio-based nano-drug carrier obtained by the invention not only has high drug loading capacity, high salt tolerance and low cytotoxicity, but also realizes responsive release of the drug under an acidic condition, and can be used for targeting and slow-release treatment of cancer cells.
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