A kind of synthetic method of cefoperazone intermediate
Through a new synthesis idea, the oximetization reaction and protection of protective group based on cyanoacetamide were solved, and the problem of fewer SM2 synthesis routes for cefbiro intermediate products was achieved, a shorter and higher selective synthetic route was achieved, reducing costs, and suitable for industrial applications.
CN119751378APending Publication Date: 2025-04-04CHONGQING SHENGHUAXI PHARMA CO LTD +1
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Patent Information
- Application Number
- CN202411973258.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-04-04
AI Technical Summary
Technical Problem
In the prior art, SM2 has fewer synthetic routes for cefbiro intermediate product, resulting in limited industrial applications.
Method used
A new synthesis idea is adopted to prepare SM2 through oximetization reaction, protection group protection, leaving group, ring formation operation and alkaline hydrolysis.
Benefits of technology
This method makes SM2 synthesis route shorter, better selectivity, lower starting material price and lower cost, and is suitable for industrial applications.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to a method for synthesizing (Z)-2-(5-amino-1,2,4-thiadiazole-3-yl)-2-((triphenoxy)imino)acetic acid (hereinafter referred to as SM2) as shown in the general structural formula I of the pyrrolidone cephalosporin antibiotic cefoperazone. The starting materials of the method are cheap and easy to obtain. Compared with the existing route, the route length is short and the overall cost is low.
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