Lipoic acid derivative with antioxidant and anti-inflammatory functions as well as preparation method and application thereof
By combining lipoic acid with curcumin and chemically modifying it, lipoic acid derivatives with higher biological activity and stability are solved, and the stability and bioavailability problems during single use are achieved, stronger antioxidant and anti-inflammatory effects are achieved, and its application in the field of drug treatment has been expanded.
CN119751414APending Publication Date: 2025-04-04JIANGSU TOHOPE PHARMA
5 Cites 0 Cited by
Patent Information
- Application Number
- CN202411905108.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-23
- Publication Date
- 2025-04-04
AI Technical Summary
Technical Problem
Lipoic acid and curcumin have problems with stability and bioavailability during single use, limiting their further promotion in drug development and clinical applications.
Method used
Through reasonable structural design, lipoic acid and curcumin are specifically combined to form lipoic acid derivatives containing curcumin structural units, and chemically modified by the preparation method of lipoic acid acid acid chloride intermediate to form more stable ester bonds.
Benefits of technology
It improves the bioavailability and chemical stability of lipoic acid derivatives, imparts stronger antioxidant and anti-inflammatory activities, and expands its application prospects in the field of drug treatment.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the field of medical chemistry, and particularly discloses a lipoic acid derivative with antioxidant and anti-inflammatory functions and a preparation method and application thereof. A preparation method with antioxidant and anti-inflammatory functions comprises preparation of a lipoic acid acyl chloride intermediate and preparation of a lipoic acid derivative, through accurate design of the molar ratio of raw materials, temperature and time, lipoic acid reacts with thionyl chloride to obtain the lipoic acid acyl chloride intermediate, then the lipoic acid acyl chloride intermediate and curcumin are subjected to a substitution reaction, and the lipoic acid derivative is obtained. The lipoic acid derivative with the antioxidant and anti-inflammatory functions can be used for treating diseases caused by oxidative stress and inflammation, and has the advantages of being more remarkable in pharmacological activity and easy to prepare and store.
Need to check novelty before this filing date? Find Prior Art