Nucleotide dimer as well as preparation method and application thereof
By using nucleotide dimers to connect to the end of the nucleotide chain as a whole during the synthesis of oligonucleic acid drugs, the problems of low synthesis efficiency and many impurities in the prior art are solved, and higher product purity and synthesis efficiency are achieved.
CN119751529AActive Publication Date: 2025-04-04RIGERNA THERAPEUTICS (BEIJING) CO LTD
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Patent Information
- Application Number
- CN202411946227.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-27
- Publication Date
- 2025-04-04
- Estimated Expiration
- 2044-12-27
AI Technical Summary
Technical Problem
It is difficult to effectively reduce impurities during the synthesis of existing oligonucleic acid drugs, resulting in low synthesis efficiency and low product purity.
Method used
Nucleotide dimers are used as a whole to connect to the end of the nucleotide chain, reducing the synthesis steps and improving the reaction efficiency, reducing the impurities produced, and higher product purity.
Benefits of technology
It significantly improves the synthesis efficiency of oligonucleic acid drugs, reduces the generation of impurities, and improves the purity of the product.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides a nucleotide dimer as well as a preparation method and application thereof, and belongs to the technical field of nucleic acid medicines. The nucleotide dimer can be used as a whole for synthesis of the nucleotide chain, and compared with two-step one-by-one nucleotide coupling, the method for synthesizing the nucleotide chain by using the nucleotide dimer provided by the invention has the advantages of few synthesis steps, improved synthesis efficiency, less generated impurities, higher purity of the obtained product and good application prospect.
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