Microneedle drug delivery device and method of making same

By employing a gentle water-absorbing and swelling mechanism and a microneedle drug delivery device driven by gastrointestinal peristalsis, the low absorption rate of oral administration of biological drugs and the pain associated with injection administration have been resolved, achieving efficient and safe drug delivery that is adaptable to the physiological differences of different patients.

CN119768151BActive Publication Date: 2026-06-23TSINGHUA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TSINGHUA UNIVERSITY
Filing Date
2023-05-31
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

Existing oral administration methods for biological drugs suffer from problems such as easy degradation and low absorption rate in the gastrointestinal tract, while injection administration is painful and inconvenient. Existing microneedle drug delivery devices have poor safety and compliance, are difficult to adapt to the physiological differences of different patients, and have poor retention effects.

Method used

The microneedles are driven to penetrate the intestinal wall by a gentle water absorption and swelling mechanism and gastrointestinal peristalsis. The microneedle array with flexible biodegradable materials and barbed structure is used to deliver drugs through a microporous structure and a controllable exposure device, avoiding external field control. Combined with intestinal contraction force, the microneedles are kept in place stably.

Benefits of technology

It improves the oral bioavailability of biological drugs, enhances safety and patient compliance, simplifies operation, improves the retention effect of microneedles in the intestinal wall, adapts to the physiological differences of different patients, and achieves efficient drug delivery.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present disclosure relates to the field of drug delivery, in particular, the present disclosure relates to a microneedle drug delivery device and a preparation method thereof. The device comprises a substrate, a microneedle array and a liquid-absorbing swelling material, the substrate carries the microneedle array, and the liquid-absorbing swelling material is arranged between the substrates to form a sandwich structure. The device uses a mild water-absorbing swelling mechanism and the natural peristalsis of the gastrointestinal tract to pierce the microneedles into the intestinal wall, complete drug delivery, physically break through the physiological barrier of oral delivery and absorption of biological drugs, and improve the oral bioavailability of biological drugs. The materials used are all biodegradable soft materials, which are safe.
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