Topical delivery of antifungal agents for treatment of fungal infections
Through nanodomain formulations that form membranes on keratinous tissues, the problem of low antifungal agent delivery efficiency in the prior art is solved, more effective treatment of alkylopathy, and the risk of adverse reactions of systemic drugs is reduced.
Patent Information
- Application Number
- CN202380060363.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2022-08-17
- Filing Date
- 2023-08-06
- Publication Date
- 2025-04-04
AI Technical Summary
The prior art In the treatment of alkylomycosis, the delivery efficiency of local antifungal agents is low, resulting in unsatisfactory treatment effects, and systemic antifungal drugs have serious adverse reactions and drug interactions.
A nanodomain dispersion in the aqueous phase was developed, including antifungal agents, hydrophilic surfactants, alcohols and polyols, which can form films on the keratinous tissue, prolong the delivery time of antifungal agents, and improve the therapeutic effect of antifungal agents through penetration and diffusion.
By extending the delivery time of antifungal agents and improving their permeability, the effectiveness of treating alkyloss disease is significantly improved, the use of systemic drugs is reduced, and the risk of adverse reactions is reduced.