A miticidal composition

Abstract

The present invention relates to a composition for controlling mites, which comprises a compound of formula (I) and at least one other compound (B). The composition for controlling mites according to the present invention has an excellent control effect on mites of the families Tetranychidae, Eriophyidae, Ixodidae, their larvae and eggs. Compound of formula (I).

Description

[0001] This application is a divisional application of application number 202110479943.7, filed on April 30, 2021, entitled "An anti-mite composition". Technical Field

[0002] This invention relates to an acaricide composition and its use in preventing or controlling mites, particularly in preventing or controlling mites, their larvae, and eggs. Background Technology

[0003] In recent years, losses caused by phytophagous mites have become increasingly severe. Mites typically live by hiding or remain dormant in secure locations. Chemical control is an important means of preventing and controlling pests in agriculture. However, the effectiveness of chemical agents against mites is limited when complete leaf coverage is not guaranteed. There is a need to find acaricides that can penetrate plants and then transfer to suitable locations.

[0004] Compound of formula (I) is known from WO2011 / 078081. It describes its use in controlling pests on crops, mites, sanitary pests, storage pests, clothing pests, and house pests. In particular, it exhibits excellent activity against mites harmful to crops and hygiene.

[0005] Compound of formula (I) However, it is not yet known whether combining compounds of formula (I) with specific insecticides can have a synergistic effect in preventing or controlling pests, particularly mites and their larvae and eggs. Summary of the Invention

[0006] The purpose of this invention is to solve the above-mentioned problems and provide an acaricide composition.

[0007] The present invention provides an acaricide composition achieved by the following technical solution: An acaricide composition comprising a compound of formula (I) and at least one other compound (B) selected from the following: (B)-1 Fluoxetine, (B)-2 Thiamethoxam, (B)-3-azoxystrobin, (B)-4 Amitraz, (B)-5-butyl urea, (B)-6 etoxazole, (B)-7 Cyclopyralid.

[0008] The acaricide composition of the present invention exhibits activity significantly higher than the sum of the activities of its individual active ingredients. There is an unexpected, genuine synergistic effect, not merely an additive effect.

[0009] The synergistic effect is particularly significant when compound (I) and other compounds (B) are present in the acaricidal composition of the present invention in a specific weight ratio. The weight ratio of compound (I) and compound (B) in the composition can vary over a wide range.

[0010]

[0011] The preferred combination of compound (I) with (B)-2 thiamethoxam, (B)-3 azoxystrobin, (B)-4 amitraz, and (B)-5 buprofen.

[0012] The acaricidal composition of the present invention can be formulated into pesticide forms, such as emulsifiable concentrates, aqueous suspensions, oil suspensions, seed-treated dry powders, seed-treated suspensions, water-dispersible granules, wettable powders, suspension emulsions, atomizers, coated granules, extruded granules, water-in-oil emulsions, microcapsule suspensions, microcapsule-suspension mixtures, dry suspensions, ultra-low volume liquids, soluble powders, granules, aerosols, etc.

[0013] The carriers used when making solid preparations can be, for example: plant powders (such as soybean flour, starch, grain flour, wood flour, bark powder, sawdust, walnut shell powder, bran, cellulose powder, coconut shell, corn cob and tobacco stem granules, residues after extracting plant essences, etc.), paper, sawdust, synthetic polymers such as crushed synthetic resins, clays (such as kaolin, saponin, acidic porcelain clay, etc.), talc, silica (such as diatomite, silica sand, mica, hydrated silicic acid, calcium silicate), activated carbon, natural minerals (pumice, palygorskite and zeolite, etc.), calcined diatomite, sand, plastic media (such as polyethylene, polypropylene, polyvinylidene chloride, etc.), inorganic mineral powders such as potassium chloride, calcium carbonate, calcium phosphate, etc., chemical fertilizers such as ammonium sulfate, ammonium phosphate, urea, ammonium chloride, etc., and soil fertilizers. These substances can be used alone or in combination of two or more.

[0014] When used as a carrier for liquid formulations, it can be, for example, water, isopropanol, butanol, ethylene glycol, methyl ethyl ketone, diisobutyl ketone, cyclohexanone, mineral oil, xylene, solvent oil, dimethylformamide, dimethyl sulfoxide, vegetable oil, animal oil, etc.

[0015] During formulation, surfactants can be added to obtain a uniform and stable morphology. Examples include fatty alcohol polyoxyethylene ethers, polyoxyethylene alkyl aryl ethers, polyoxyethylene higher fatty acid esters, phosphate esters of polyoxyethylene alcohols or phenols, fatty acid esters of polyols, naphthalene sulfonic acid polymers, lignin sulfonates, branched copolymers of high molecular weight combs, butyl naphthalene sulfonates, alkyl aryl sulfonates, sodium alkyl sulfosuccinate, oils, fatty alcohols and ethylene oxide condensates, polyacrylates of alkyl taurine, protein hydrolysates, suitable oligosaccharides, or polymers, such as those based on ethylene monomers alone, acrylic acid, polyoxyethylene and / or polyoxypropylene, or combinations thereof with, for example, (poly)ols or (poly)amines.

[0016] Optionally, the formulation may also include other additional components, such as protective colloids, binders, thickeners, thixotropic agents, penetrants, stabilizers, and masking agents.

[0017] When the composition of the present invention is formulated, the content of compound (I) and compound (B) is preferably 0.01 to 90% by weight, more preferably 0.05 to 85% by weight.

[0018] The acaricide composition is used for the prevention or control of mites and their larvae and eggs.

[0019] The acaricide composition is used for the prevention or control of mites belonging to the Tetranychidae, Erythrophagaceae, and Ixodidae families.

[0020] The acaricide composition is used for the prevention or control of two-spotted spider mites, citrus pterocarya, carmine spider mites, tea gall mites, and haematomarginatus.

[0021] The purpose of the described acaricide composition for treating seeds to prevent seed infestation by mites.

[0022] The acaricide composition is used to prevent soil mite infestation by applying it to soil and / or directly to soil in contact with plant roots or soil suitable for plant growth.

[0023] A method for preventing or controlling mites and their larvae and eggs, comprising applying the acaricidal composition to a target useful plant, a target mite or its environment, or the propagation material of the target useful plant.

[0024] A method for preventing or controlling mites and their larvae and eggs, comprising applying the acaricide composition to seeds, target useful plants, or soil in which plants grow or soil suitable for plant growth.

[0025] A method for preventing or controlling mites and their larvae and eggs, comprising applying the acaricide composition to the soil before, after, or before and after seed germination and / or directly to the soil in contact with the plant roots or to soil suitable for plant growth.

[0026] The acaricide compositions of the present invention include not only those that can be immediately applied to the object to be treated using suitable equipment such as spraying or dusting devices, but also concentrated commercial compositions that need to be diluted before application to the object.

[0027] The acaricidal composition of the present invention can be formulated into an application-suitable preparation in the form of a composition of its active ingredient compounds, or in the form of a combination of appropriate doses of a commercially available formulation.

[0028] The acaricide composition of the present invention can be applied undiluted or diluted with water.

[0029] The acaricide composition of the present invention has the effects of killing adult insects, nymphs, larvae and eggs, and therefore can be used for the prevention and control of pests, mites, sanitary pests, stored grain pests, clothing pests and house pests that attach to crops.

[0030] In particular, the acaricidal composition of the present invention can effectively control mites that are harmful to crops and hygiene. The acaricidal composition provided by the present invention is suitable for preventing or controlling the following mites: Mites belonging to the family Tetranychidae: Two-spotted spider mite (Tetranychus urticae), hawthorn spider mite (Tetranychus viennensis), cinnabarinus spider mite (Tetranychus cinnabarinus), citrus spider mite (Panonychus citri), apple spider mite (Panonychus ulmi), geniculatus geniculate spider mite (Eotetranychus geniculatus), plum spider mite (Eotetranychus pruni), Asian spider mite (Eotetranychus sexmanaculatus), smithi spider mite (Eotetranychus smithi), uncatus spider mite (Eotetranychus uncatus), boreus spider mite (Eotetranychus boreus), hondoensis spider mite (Oligonychus hondoensis), ilicis spider mite (Oligonychus ilicis), larch spider mite (Oligonychus ilicis). The species include: karamatus, Panonychus mori, Tenuipalpus zhizhilashviliae, Tetranychus kanzawai, Tuckerella pavoniformis, Brevipalpus lewisi, Brevipalpus obovatus, Brevipalpus sphoenicis, Bryobia praetiosa, Bryobia rubrioculus, and Dolichotetranychus floridanus. Mites belonging to the family Ixodidae include: Haemaphyxalis longicornis, Haemaphysalis japonica, Boophilus microplus, Dermacentor recticulatus, Dermacentor truncatus, Haemaphysalis flava, Ixodes ovatus, Ixodes persulcatus, and Dermacentor reticulatus. Mites belonging to the family Eriophyidae include: tea gall mite (Calacarus carinatus), tomato gall mite (Aculops lycopersici), pelekassi gall mite (Aculops pelekassi), apple rust mite (Aculus schlechtendali), carnation gall mite (Aceria paradianthi), grape leaf rust mite (Calepitrimerus vitis), grape lobe gall mite (Colomerus vitis), pear gall mite (Epitrimerus pyri), wolfberry gall mite (Eriophes kuko), tulip gall mite (Aceria tulipae), false pear rust mite (Eriophyes chibaensis), tea leaf rust mite (Acaphylla theavagrans), and foetidae (Aculus fockeui), etc. Mites belonging to the family Astigmata include: Acarus siro, Aleuroglyphus ovatus, Carpoglyphus lactis, Lardoglyphus konoi, Rhizoglyphus echinopus, Rhizoglyphus robini, Tyrophagus putrescentiae, and Tyrophagus similis. Mites belonging to the family Tarsonemidae include: Primrose Plant-eating Mite (Phytonemus pallidus), Lateral Polyphagotarsonemus latus, Two-leaf Tarsonemus (Tarsonemus bilobatus), and Waitei Tarsonemus, etc. Mites belonging to the family Eupodidae include: cabbage mite (Penthaleus erythrocephalus), wheat claw mite (Penthaleus major), etc. In addition, examples of drug-resistant mites that are resistant to previously known acaricides can also be cited.

[0031] The acaricidal composition of the present invention is particularly suitable for controlling mites of the Tetranychidae, Erythrophagaceae, and Ixodidae families, as well as their larvae and eggs.

[0032] The acaricidal composition of the present invention is particularly suitable for controlling two-spotted spider mites, citrus spider mites, carmine spider mites, tea gall mites, haematomarginatus and their larvae and eggs.

[0033] The acaricide composition of this invention unexpectedly exhibits extremely high activity in preventing or controlling mites, their larvae, and eggs when applied to plants, seeds, and soil in which plants grow. Examples of plants include: plant stems and leaves, plant flowers, and plant fruits.

[0034] Due to the multigenerational and adaptive nature of mites, their resistance develops in a relatively short period. The acaricidal composition of this invention exhibits superior penetration and excellent efficacy against mites, their larvae, and eggs. The acaricidal composition of this invention demonstrates excellent control efficacy against mites, their larvae, and eggs even at low doses.

[0035] The acaricidal composition of the present invention combines rapid and long-lasting action, and allows for effective pest control even at reduced dosage rates of the active ingredient. The acaricidal composition of the present invention also reduces or avoids adverse environmental or toxicological effects.

[0036] The acaricide composition of the present invention can be applied to seeds, plants, or soil in which plants grow or soil suitable for plant growth. The acaricide composition of the present invention can be applied in any desired manner, such as seed coating, soil irrigation, and / or direct furrow application and / or foliar spraying.

[0037] Therefore, the present invention provides a method for preventing and controlling mites and their larvae and eggs, comprising applying the acaricidal composition of the present invention to seeds, target useful plants, or soil in which plants grow or soil suitable for plant growth.

[0038] The acaricide composition of the present invention can be applied to the soil before, after, or before and after seed germination and / or directly to the soil in contact with the plant roots or to soil suitable for plant growth.

[0039] Seeds can also be contacted with an effective amount of the acaricide composition of the present invention before sowing and / or after germination to prevent soil mites and protect seedling roots and branches from soil and leaf mites. Seeds treated with the acaricide composition of the present invention can be stored, managed, sown, and cultivated.

[0040] The acaricidal compositions of the present invention include not only ready-to-use compositions that can be applied to plants, seeds, and soils for plant growth using suitable devices, but also commercially available concentrates that must be diluted with water before application.

[0041] This invention also provides a method for protecting useful crops from mite infestation and its larvae and eggs, comprising applying the active ingredient (I) compound and compound (B) together, separately, or sequentially. In the case of separate application, the order generally has no effect on the outcome of the control measure.

[0042] The acaricide composition of the present invention exhibits activity significantly higher than the sum of the activities of its individual active ingredients. There is an unexpected, genuine synergistic effect, not merely an additive effect.

[0043] When the compound of formula (I) of the present invention is present in the acaricidal composition of the present invention in a specific weight ratio with other compounds (B), the synergistic effect is particularly significant. Detailed Implementation

[0044] Biological test example: Experiment 1: Ovicidal efficacy test against eggs of the citrus parsnipus mite The active ingredients of compound (I) and compound (B) were dissolved in acetone to prepare single-agent stock solutions, which were then diluted with an aqueous solution containing 0.1% Tween-80 to the required concentration.

[0045] Leaf butterflies carrying mite eggs from the same day were examined and counted under a microscope. The leaf butterflies were then immersed in a solution of a specific concentration of the pesticide for 5-15 seconds, removed, and cultured under humid conditions. The treated mite eggs and leaf butterflies were then cultured under normal conditions. Each treatment was repeated four times, with a blank control included. Eggs that had not hatched by the time all blank control eggs had hatched were considered dead. The hatching inhibition rate was calculated at the end of the experiment.

[0046] Hatching inhibition rate = [(hatching rate of control eggs - hatching rate of treated eggs) / hatching rate of control eggs] x 100% Furthermore, the theoretical hatching inhibition rate (%) can be calculated using the Colby formula. When the hatching inhibition rate (%) is higher than the theoretical hatching inhibition rate (%), the composition of the present invention has a synergistic effect. The theoretical mortality rate (%) according to the Colby formula is shown in parentheses in Tables 1-6.

[0047] Table 1

[0048] Table 2

[0049] Table 3

[0050] Table 4

[0051] Table 5

[0052] Table 6

[0053] Formulation Examples: Example 1: 40% Formula (I) compound + 5% Thiamethoxam wettable powder Compound (I) 40% Thiamethoxam 5% 5% alkylnaphthalene sulfonate 10% silica Kaolin content increased to 100%. The above components are mixed and pulverized by an ultrafine pulverizer to obtain 40% compound (I) + 5% thiamethoxam wettable powder.

[0054] Example 2: 30% of Formula (I) compound + 3% azoxystrobin emulsifiable concentrate Compound (I) 30% 3% azoxystrobin 7% polyoxyethylene alkyl allyl ether Calcium dodecylbenzenesulfonate 3% 30% dimethylformamide Solvesso TM 200, bring the total to 100%. Mix the above components and stir until a transparent and homogeneous phase is obtained, resulting in 30% compound (I) + 3% azithromycin emulsifiable concentrate.

[0055] Example 3: 12.5% ​​Compound (I) + 12.5% ​​Dimethylamidine Emulsifiable Concentrate Compound (I) 12.5% Amitraz 12.5% 3% ethoxylated castor oil Calcium dodecylbenzenesulfonate 2% N-Methylpyrrolidone 25% Solvesso TM 200, bring the total to 100%. The above components were mixed and stirred until a transparent and homogeneous phase was obtained, yielding 12.5% ​​of compound (I) + 12.5% ​​of dimethicone emulsion.

[0056] Example 4: 10% of Formula (I) compound + 50% butyl ether urea water-dispersible granules Compound (I) 10% 50% butyl urea Sodium lignosulfonate 4% Sodium dodecyl sulfate 3% 6% silica Diatomaceous earth replenished to 100%. The above components are mixed and pulverized into a wettable powder by air jet milling. A certain amount of water is then added, and the mixture is extruded and granulated. After drying and sieving, a 10% compound of formula (I) + 50% butyl urea water-dispersible granules are obtained.

Claims

1. The use of an acaricidal composition for the prevention or control of eggs of the citrus parsnipal mite, characterized in that, The active ingredient of the composition consists of compound (I) and (B):(B)-2 thiamethoxam, wherein the weight ratio of compound (I) to compound (B)-2 is 10:1 to 1:

1. 。 2. The use according to claim 1, characterized in that, The weight ratio of compound (I) to compound (B)-2 is 10:1 to 2:

1.

3. The use according to claim 1, characterized in that, The weight ratio of compound (I) to compound (B)-2 is 5:1 to 2:

1.

4. The use according to claim 1, characterized in that, The acaricide composition of claim 1 is used on a target useful plant, a target mite or its environment, or the propagation material of the target useful plant.

5. The use according to claim 1, characterized in that, The acaricide composition of claim 1 is applied to seeds, the target useful plant, or the soil in which the plant grows or soil suitable for plant growth.

6. The use according to claim 1, characterized in that, The acaricide composition of claim 1 is applied to the soil before, after, or before and after seed germination and / or directly to the soil in contact with the plant roots or to soil suitable for plant growth.

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