Lactobacillus rhamnosus and its applications

By providing Lactobacillus rhamnosus CGMCC No. 33153, the problem of single function in the existing technology is solved, and a multi-functional effect of anti-inflammation, promoting skin repair and inhibiting pathogenic bacteria is achieved, as well as promoting cell growth and collagen production.

CN120098865BActive Publication Date: 2025-11-14COFCO NUTRITION AND HEALTH RESEARCH INSTITUTE CO LTD +1
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Patent Information

Application Number
CN202510587285.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-05-08
Publication Date
2025-11-14
Estimated Expiration
2045-05-08

AI Technical Summary

Technical Problem

Existing Lactobacillus rhamnosus microbial preparations have relatively limited functions and need to be used in combination with other probiotics to achieve better results. They cannot simultaneously achieve the functions of anti-inflammation and promoting the production of skin repair substances.

Method used

We provide a strain of Lactobacillus rhamnosus CGMCC No. 33153, which promotes cell growth and repair by regulating inflammation and apoptosis-related genes, and produces high levels of lactic acid and hydrogen peroxide, specifically and non-specifically inhibiting pathogenic bacteria.

Benefits of technology

This strain can reduce the production of inflammatory factors, promote skin repair, enhance cell growth activity, inhibit various pathogens, and promote the expression of aquaporins and collagen, thus having broad application potential.

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Abstract

This invention relates to the field of microbiology and discloses a strain of *Lactobacillus rhamnosus* and its applications. The *Lactobacillus rhamnosus* strain provided by this invention, with accession number CGMCC No. 33153, exhibits strong reproductive capacity and high production of lactic acid and hydrogen peroxide, demonstrating strong antibacterial properties. It has potential applications in organisms; it can regulate genes related to inflammation and apoptosis, thereby reducing the production of inflammatory factors and promoting cell growth and repair; it can also upregulate the gene expression of aquaporins and collagen, thereby promoting skin repair.
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