Novel esterases and uses thereof
By designing a new esterase, using the specific substitution positions of the amino acid sequence to improve its activity and thermal stability, the problem of insufficient activity and thermal stability of existing esterases when degrading polyester materials is solved, and a more efficient polyester degradation effect is achieved.
CN120173910APending Publication Date: 2025-06-20CARBIOS (100 00)
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Patent Information
- Application Number
- CN202510331685.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2018-07-27
- Filing Date
- 2019-07-26
- Publication Date
- 2025-06-20
AI Technical Summary
Technical Problem
Existing esterases have insufficient activity and thermal stability when degrading polyester materials, making it difficult to provide a more effective polyester degradation method.
Method used
A novel esterase is designed with an amino acid sequence of at least 75% identity to the parent esterase and is replaced at specific amino acid positions to improve its activity and thermal stability in degraded polyester materials.
Benefits of technology
The novel esterase exhibits significantly improved activity and thermal stability when degrading polyester materials, especially PET, and can maintain efficient degradation performance at higher temperatures.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to novel esterases, and more particularly to esterase variants having improved activity and / or improved thermal stability as compared to the esterase of SEQ ID N DEG 1 and their use in degrading polyester-containing materials, such as plastic articles. The esterase provided by the invention is particularly suitable for degrading polyethylene glycol terephthalate and materials containing polyethylene glycol terephthalate.
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