A bacterial cellulose injectable gel and a method for its preparation

Through the multiple cross-linked network design of bacterial cellulose injectable gel, the problems of insufficient water retention, controlled degradability and biocompatibility of injectable gel are solved, and the effects of high water retention, long-term tissue repair and injectable operation are achieved.

CN120459372BActive Publication Date: 2025-10-17SUZHOU HVHA MEDICAL TECH DEV CO LTD
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Patent Information

Application Number
CN202510970035.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-07-15
Publication Date
2025-10-17
Estimated Expiration
2045-07-15

AI Technical Summary

Technical Problem

Existing injectable gels have deficiencies in water retention, controlled degradation and biocompatibility, and cannot achieve both biosafety, long-term tissue repair function and injectable operability.

Method used

Bacterial cellulose injectable gel is made of a combination of sulfonated bacterial cellulose, sodium alginate, and ionic water-retaining agents (such as polylysine, chitosan, and sodium carboxymethyl cellulose) to form a multiple cross-linked network, which improves the mechanical properties, water retention, and degradation cycle of the gel, ensuring its long-term stability after injection.

Benefits of technology

It enhances the water retention, mechanical stability and controllable degradation of the gel, provides good biocompatibility and long-term tissue repair function, and achieves a stable support effect without the need for frequent injections.

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Abstract

The application relates to the field of biological medicine, in particular to a bacterial cellulose injectable gel and a preparation method thereof. The bacterial cellulose injectable gel comprises the following components: 1-5% of a sulfonated bacterial cellulose dispersion solution, 3-5% of sodium alginate, 1-3% of an ionic water-retaining agent, 0.1-1% of a crosslinking agent, and the rest is water; the ionic water-retaining agent comprises one or more of polylysine, chitosan and sodium carboxymethyl cellulose. In order to solve the problems of insufficient water-retaining property, controllable degradability and biocompatibility of the existing injectable gel, the prepared bacterial cellulose injectable gel is uniform and stable, the formed gel has the excellent effects of good support, not easy to flow and controllable degradation. The injectable gel has high water retention and strength, no foreign matter in degradation and good compatibility and no irritation, so that the prepared injectable gel can be kept in a stable state for a long time without being degraded, and frequent injection is not needed.
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