Culture container for tissue engineering cartilage scaffold

By designing tissue-engineered cartilage scaffold culture containers with hydrophobic and breathable functions, the number of clamping is reduced, the problems of cell damage and shedding are solved, the cell adhesion rate and migration ability are improved, and the consistency and repeatability of the treatment effect are ensured.

CN120484961APending Publication Date: 2025-08-15BEIJING TIANYOU QIYUAN BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510893217.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-30
Publication Date
2025-08-15

AI Technical Summary

Technical Problem

During the culture of existing tissue-engineered cartilage scaffolds, frequent clamping operations lead to cell damage and shedding, affecting cell utilization and treatment effects, and there is a risk of contamination, making it difficult to promote and apply on a larger scale.

Method used

A tissue-engineered cartilage scaffold culture container is designed, including a first container and a second container. The second container has a hydrophobic and breathable function. The top pressure component limits the displacement of the scaffold, reduces the number of clamping times, and realizes gas exchange through the hydrophobic and breathable function, avoids cell floatation and adherence to the wall, and uses a shock-proof sponge to buffer vibration.

Benefits of technology

It significantly improves the culture quality of chondrocytes, reduces the risk of cell damage and drop, improves cell adhesion rate and migration ability, and ensures consistency and repeatability of treatment effects.

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Abstract

The invention provides a culture container of a tissue engineering cartilage scaffold, comprising: a first container having a first opening and a first chamber; the first cover body is mounted on the first container and used for covering the first opening; the second container is used for being placed in the first cavity, the second container is provided with a second opening and a second cavity, the second cavity is used for placing a tissue engineering cartilage scaffold, and the bottom of the second container has a hydrophobic and breathable function, so that a gas medium can enter the second cavity through the bottom of the second container; the second cover body is mounted on the second container and used for covering the second opening, and the second cover body is connected with the first cover body; the jacking and pressing part is mounted on the second cover body, is positioned on one side, deviating from the first cover body, of the second cover body, and is used for limiting the displacement distance of the tissue engineering cartilage scaffold in the second container towards the second opening direction; the technical problem that the collagen scaffold needs to be repeatedly clamped in an existing culture mode is solved, and the collagen scaffold is prevented from floating or adhering to the wall in the culture and transportation process.
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