Injectable temperature-sensitive hydrogel sustained-release medicinal preparation for in-situ generation of local anesthetic microrod and application of injectable temperature-sensitive hydrogel sustained-release medicinal preparation in long-acting anesthesia and analgesia
By self-assembly injectable temperature-sensitive hydrogel preparations forming local anesthetic microrods in the hydrogel, the problem of poor water solubility of local anesthetics is solved, and the effects of long-term anesthesia and local anesthesia are achieved, and good biocompatibility and safety are good.
Patent Information
- Application Number
- CN202510641352.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-19
- Publication Date
- 2025-08-19
AI Technical Summary
The poor water solubility of existing local anesthetics leads to a short effective time, making it difficult to meet the needs of long-term analgesia. The synthesis of existing drug carrier materials is complex, costly and has great safety risks.
Local anesthetic microrods are prepared by injectable temperature-sensitive hydrogels. The pH is adjusted to weak alkaline by adding alkaline pH regulators, so that local anesthetics can self-assemble in the hydrogel to form a micron-scale rod-like structure to form an injectable temperature-sensitive hydrogel sustained release drug preparation.
It achieves the sustained release effect of local anesthetics, extends the time of anesthesia and analgesia, has good biocompatibility, high safety, and low cost. It is suitable for a variety of local anesthesia and analgesia needs, and is simple to prepare.