A multifunctional wound patch combined with electrical stimulation therapy and its preparation method and application

The multi-layer wound patch prepared by electrospinning technology solves the problem that traditional dressings cannot actively intervene in wound healing, realizes exudate discharge and electrical stimulation treatment, promotes wound healing, reduces the risk of infection, and provides personalized treatment strategies.

CN120501915BActive Publication Date: 2025-09-23SOUTHWEST JIAOTONG UNIV
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Patent Information

Application Number
CN202510985891.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-07-17
Publication Date
2025-09-23
Estimated Expiration
2045-07-17

AI Technical Summary

Technical Problem

Traditional dressings are unable to actively intervene in the wound healing microenvironment, resulting in a long healing cycle, high recurrence rate, and accumulation of exudate causing infection or adhesion of the dressing to the wound. Existing electrical stimulation equipment needs to be used in the hospital and is prone to secondary damage.

Method used

Electrospinning technology is used to prepare a multi-layer wound patch, including a hydrophilic electrospun fiber membrane, a drug-loaded hydrophobic electrospun fiber membrane, a conductive ink layer and a conductive hydrogel layer, to achieve directional discharge of exudate, antibacterial and anti-inflammatory effects, and electrical stimulation therapy and impedance monitoring through the conductive hydrogel.

Benefits of technology

It achieves good maintenance of the wound environment, promotes healing, reduces the risk of infection, provides personalized treatment strategies, enhances electrode fit and antibacterial properties, and improves healing efficiency.

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Abstract

The present invention discloses a multifunctional wound patch for combined electrical stimulation therapy, as well as its preparation method and application, and relates to the field of medical material technology. The multifunctional wound patch comprises a double-layer electrospun fiber membrane, a conductive ink layer, and a conductive hydrogel layer. The surface of the hydrophobic fiber layer (the side directly contacting the wound) is integrated with a pair of serpentine concentric conductive electrodes written with conductive ink, and the ends of the two electrodes can be drawn with square conductive ports of corresponding sizes as needed. The surface of the conductive electrode pair is encapsulated with a conductive hydrogel with antibacterial function. External electrical signals can be transmitted to the electrode pair of the patch through the conductive ports of the electrode pair, and then act on the wound through the conductive hydrogel layer to achieve on-demand electrical stimulation treatment of the wound. The multifunctional wound patch for combined electrical stimulation therapy prepared by the present invention can achieve the discharge of excess exudate and ensure a good wound environment; the loaded curcumin drug has antibacterial, antioxidant, and healing effects on the wound.
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