Synthesis method of natural product Calceramide B

Calcicamide B was successfully synthesized by reducing debenzyl, introducing indole glyoxyl and removing tert-butylsulfinyl, which solved the problem of lack of synthetic routes in the prior art, and achieved an efficient and low-cost synthetic route design with a yield of 71%.

CN120518518APending Publication Date: 2025-08-22HUNAN UNIV OF CHINESE MEDICINE
0 Cites 0 Cited by

Patent Information

Application Number
CN202510832147.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-20
Publication Date
2025-08-22

AI Technical Summary

Technical Problem

The failure of the prior art to provide an efficient synthesis route for Calcicamide B hinders further research and development of this natural product.

Method used

Calcicamide B is synthesized by reducing debenzyl, introducing indole glyoxyl group, and removing tert-butylsulfinyl group using compounds as raw materials. The reaction route is novel, simple to operate and high yield.

Benefits of technology

The efficient synthesis of Calcicamide B was achieved, with a yield of 71%, mild reaction conditions and low cost, providing a research basis for this natural product.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention provides a synthesis method of a natural product Calceamide B, and belongs to the technical field of synthesis of natural products. According to the invention, a compound # imgabs0 # is used as a raw material, and a target molecule Calceamide B is obtained through reduction debenzylation, introduction of indole acetaldehyde acyl and removal of tert-butyl sulfinyl. The synthesis route provided by the invention is novel, unique and reasonable in design thought, has the advantages of mild reaction conditions, high yield, simplicity and convenience in operation, low synthesis cost and the like, and provides a basis for further research and development of the natural product Calceamide B.
Need to check novelty before this filing date? Find Prior Art