Kit for early diagnosis of young acute coronary syndrome based on plasma transcriptomics and application thereof

By analyzing the expression levels of specific proteins in plasma and combining machine learning methods, a risk scoring model for acute coronary syndrome in young people was established, which solved the problem of insufficient existing diagnostic methods and achieved early, accurate diagnosis and personalized treatment of acute coronary syndrome in young people.

CN120668931APending Publication Date: 2025-09-19SHENZHEN PEOPLES HOSPITAL
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Patent Information

Application Number
CN202510680127.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-26
Publication Date
2025-09-19

AI Technical Summary

Technical Problem

Existing diagnostic methods for acute coronary syndrome in young people mainly rely on clinical research and experience in middle-aged and elderly people, which makes them difficult to apply to young people. In addition, there is a lack of large-scale, multi-omics research, resulting in insufficient diagnostic standards and treatment plans, and an inability to effectively address the high mortality and disability rates of acute coronary syndrome in young people.

Method used

By analyzing the expression levels of twelve proteins in plasma, including FAM178B, ARVCF, SLC6A9, BNC2, DKK2, CLSTN3, SEMA6B, DAB2IP, LUC7L, NIPAL4, RBFOX3, and ST18, and combining random forest, LASSO regression, and XGBOOST machine learning methods, a risk scoring model for acute coronary syndrome in young people was established, providing a non-invasive and rapid early diagnosis method.

Benefits of technology

It has achieved early and accurate diagnosis of acute coronary syndrome in young people, improved the sensitivity and specificity of diagnosis, reduced mortality and disability rates, and provided personalized treatment plans.

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Abstract

The invention discloses a kit for early diagnosis of young acute coronary syndrome based on plasma transcriptomics and application of the kit. The invention provides a computer device which comprises a processor and a computer program, and the processor executes the computer program to realize the following steps: S1) data receiving: receiving expression quantities of twelve proteins in a plasma sample of a patient to be detected; s2) data processing: substituting the expression quantities of the twelve proteins into a prognosis risk prediction model, and calculating to obtain a risk score value of a to-be-detected patient as a high-risk young coronary heart disease patient; and S3) data output: analyzing the possibility that the to-be-detected patient is a high-risk young coronary heart disease patient according to the risk score value. According to the early diagnosis kit and device for the young acute coronary syndrome, the acute coronary syndrome of a patient can be rapidly judged by detecting the transcriptional expression quantity of twelve proteins in peripheral venous blood plasma of the young patient, non-invasive detection and diagnosis are rapid and accurate, operation is easy, and repeatability is good.
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