Preparation method of iron-based nano cascade catalyst and application of iron-based nano cascade catalyst in sterilization and treatment of diabetic wounds

By preparing Fe@Au NRs nanocatalysts, combining GOx-like and POD-like enzyme activities, and using visible light activation to produce ·OH, the sterilization problem of diabetic wounds in weakly acidic and low H2O2 environments was solved, achieving efficient antibacterial and wound healing effects.

CN120715213APending Publication Date: 2025-09-30QINGDAO UNIV
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Patent Information

Application Number
CN202510900777.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-01
Publication Date
2025-09-30

AI Technical Summary

Technical Problem

In the existing technology, nanozyme catalysts used for diabetic wounds cannot effectively produce sufficient ·OH in a weakly acidic and low H2O2 environment, resulting in poor bactericidal effect. In addition, the addition of exogenous H2O2 is difficult to control and may cause damage to normal tissues.

Method used

Fe@Au NRs nanocatalysts were prepared by a hydrothermal method, combined with GOx-like and POD-like enzyme activities, and photodynamic sterilization was achieved by visible light activation to produce ·OH, thereby realizing enzyme cascade catalysis.

Benefits of technology

It significantly improves the antibacterial effect against bacteria under visible light, promotes diabetic wound healing, and the preparation method is simple, and the product has good biocompatibility.

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Abstract

The invention belongs to the technical field of preparation and antibiosis of nano materials, and relates to a preparation method of an iron-based nano cascade catalyst and application of the iron-based nano cascade catalyst in sterilization and treatment of diabetic wounds, ferrous chloride is taken and dissolved in ethyl alcohol to prepare a solution A, gentisic acid is taken and dissolved in N, N-dimethylformamide to obtain a solution B, then the solution A is slowly dropwise added into the solution B, stirring is carried out, and the iron-based nano cascade catalyst is obtained. Heating for reaction, and centrifuging to obtain a blue precipitate, namely Fe NRs; and adding a chloroauric acid aqueous solution into the Fe NRs aqueous solution, and adding a sodium borohydride aqueous solution for reaction to obtain the iron-based nano cascade catalyst. The catalyst simultaneously has GOx-like and POD-like enzyme activity and a photodynamic effect, has a remarkable antibacterial effect on bacteria under visible light and is particularly suitable for resisting bacteria of diabetic wounds, the preparation method is simple in process, the antibacterial effect of the product is remarkable, and the catalyst has the advantages of promoting wound healing, being good in biocompatibility and the like and is suitable for industrial production. And the market prospect is wide.
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