Coated formulations
By using a hydrophilic gel skeleton for sustained release and an antioxidant in the celodoxine sustained-release formulation, and by adding a plasticizer to the coating material, the compatibility problem between the sustained-release material and the active ingredient was solved, the impurity content was reduced, and the antioxidant content was stabilized, thus achieving long-term stability and sustained-release effect of the formulation.
Patent Information
- Application Number
- CN202411407469.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2024-04-12
- Filing Date
- 2024-10-10
- Publication Date
- 2025-10-21
AI Technical Summary
In existing celodoxine formulations, compatibility issues between sustained-release materials and active ingredients lead to increased impurity content, and the content of antioxidants decreases during storage, which cannot be effectively addressed by existing coating materials.
A silodosin sustained-release preparation containing a hydrophilic gel skeleton sustained-release material and an antioxidant is used, and a plasticizer is added to the coating material to improve the stability and compatibility of the preparation.
This achieved a good sustained-release effect for celodoxine extended-release formulation, reduced the increase in impurity content, improved the stability of antioxidants, and ensured the long-term stability of the formulation.