Stapled peptide compound, preparation method and application thereof, and skin care product

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By preparing highly hydrolysis-resistant and stable staple peptide compounds, the problem of easy degradation of polypeptide compounds under physiological conditions has been solved, achieving long-lasting and highly efficient collagen expression capabilities, which can be applied to anti-wrinkle, anti-aging and repair skin care products.

CN120865342AInactive Publication Date: 2025-10-31GUANGDONG MARUBI BIOLOGICAL TECH CO LTD

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Patent Information

Application Number: CN202511198912.9
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2025-08-25
Publication Date: 2025-10-31
Estimated Expiration: Not applicable · inactive patent

Application Information

Patent Timeline

25 Aug 2025

Application

CN202511198912.9

31 Oct 2025

Publication

CN120865342A

IPC: C07K7/06; A61K8/64; A61Q19/08; A61Q19/00

CPC: C07K7/06; A61K8/64; A61Q19/08; A61Q19/00

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Application Domain

Cosmetic preparations Toilet preparations

Technology Topics

Chemical compound Aging resistance

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AI Technical Summary

Technical Problem

Traditional polypeptide compounds are easily degraded under physiological conditions, affecting the long-term efficacy of their compounds.

Method used

By binding two side chain residues of a linear polypeptide to form a staple peptide compound, and then reacting it with activated glutaric acid in a catalyst system, a staple peptide compound with high hydrolysis resistance was prepared.

Benefits of technology

Dating peptides are not easily degraded under physiological conditions, have a long physiological half-life, and significantly enhance the collagen expression capacity of fibroblasts, making them suitable for anti-wrinkle, anti-aging, and repair applications.

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Abstract

The invention relates to the technical field of polypeptide compounds, in particular to a stapled peptide compound, a preparation method and application thereof and a skin care product. The structural formula of the stapled peptide compound is shown in the specification. The polypeptide has high anti-hydrolysis stability, can significantly improve the expression ability of up-regulated fiber cells and promote the expression of collagen, and can be used in the fields of wrinkle resistance, aging resistance, repair and the like.

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