Integrated membrane oxygenator

Abstract

The invention relates to the technical field of medical apparatus and instruments, and particularly discloses an integrated membrane type oxygenator which comprises a blood storage cylinder, an oxygenator body, a membrane assembly, an oxygenator cover, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe and an oxygen supply pipe, the oxygenation shell comprises a variable-temperature silk membrane structure and an oxygenation silk membrane structure from inside to outside, the fluid optimization structure is arranged in the oxygenation shell and used for optimizing the blood flowing state or purifying blood, the oxygenation shell is provided with a blood outlet pipe, the blood outlet pipe is arranged close to the lower cover, and the lower cover is provided with a water inlet pipe; by integrating the blood storage cylinder, the oxygenator body and the fluid optimization structure, the integrated function of blood storage, oxygenation and flowing or purification is achieved, the basic structure is adaptive to various clinical scenes, and the integration level and practicability of the device are improved.

Description

Technical Field

[0001] The invention relates to the field of medical device technology, specifically to an integrated membrane oxygenator. Background Technology

[0002] Membrane oxygenators, as key medical devices that replace human lung function, are widely used in scenarios such as extracorporeal circulation during cardiac surgery, treatment of acute respiratory failure, and transition to lung transplantation. Their core function is to achieve efficient exchange of oxygen and carbon dioxide in the blood and maintain the stability of the blood's physiological state.

[0003] In existing technologies, the blood flow status and the utilization rate of the membrane structure are key factors affecting the performance of membrane oxygenators. Traditional oxygenators generally suffer from the following problems:

[0004] 1. Uneven blood flow distribution: After blood enters the oxygenator, it is easy to form turbulence or local stagnation, resulting in a limited contact area with the oxygenation membrane. In some areas, the membrane utilization rate is less than 30%, and the oxygenation efficiency is low.

[0005] 2. Risk of hemolysis and thrombosis: The high shear force generated by turbulence can easily damage red blood cells (high hemolysis rate), and blood stasis areas are prone to thrombosis, increasing the risk of clinical complications;

[0006] 3. Lack or inefficient purification function: Most oxygenators do not integrate a targeted filtration structure, which cannot effectively intercept impurities such as microthrombi and air bubbles in the blood. Additional filtration devices need to be connected in series, which increases the complexity of the system and the resistance to blood flow.

[0007] The purpose of this invention is to provide an integrated membrane oxygenator to solve the problems mentioned in the background art. Summary of the Invention

[0008] To achieve the above objectives, the invention provides an integrated membrane oxygenator, including a blood storage cylinder with a closed chamber, a blood inlet at the upper part of the closed chamber and a bleeding outlet at the lower part;

[0009] The oxygenator body, connected to the bleeding port of the blood storage cylinder, includes an oxygenation shell, an upper cover, a lower cover, and a spindle. The upper cover and the lower cover are respectively sealed to the upper and lower ends of the oxygenation shell.

[0010] The membrane module is located inside the oxygenation shell and sleeved on the outside of the mandrel, and from the inside to the outside includes a variable temperature filament membrane structure and an oxygenation filament membrane structure;

[0011] A fluid optimization structure, located within the oxygenation shell, is used to optimize blood flow or purify blood.

[0012] The oxygenation shell is equipped with an outlet tube, which is located near the lower cover. The lower cover is equipped with a water inlet pipe. The top center and side wall of the upper cover are respectively equipped with an inlet tube and an oxygen inlet pipe. The inlet tube is connected to the core shaft. By integrating the blood storage cylinder, the oxygenator body and the fluid optimization structure, the integrated functions of blood storage, oxygenation and flow / purification are realized. The basic structure is adaptable to various clinical scenarios, improving the integration and practicality of the equipment.

[0013] As a further improvement to the invention, the fluid optimization structure includes a biomimetic branching channel assembly located between the mandrel and the membrane assembly. The biomimetic branching channel assembly is provided with a main diverter, a secondary guide plate, and a tertiary guide plate in sequence along the blood flow direction to achieve graded diversion and guidance of blood. The graded diversion design of the biomimetic branching channel assembly optimizes the blood flow path, reduces turbulence, improves the uniformity of contact between blood and the membrane assembly, and enhances oxygenation efficiency.

[0014] As a further improvement to the invention, the main diverter includes a frustum-shaped structure, and the frustum-shaped structure is provided with multiple guide holes for diverting blood. The guide holes are distributed along the circumference and correspond to the diversion channels of the secondary guide plate. The frustum-shaped main diverter achieves the initial orderly diversion of blood by precisely corresponding with the secondary guide plate through the guide holes, avoiding local blood flow concentration and reducing the risk of hemolysis.

[0015] As a further improvement to the invention, the main diverter also includes a variable cone angle truncated cone structure, which includes an upper cone and a lower cone. The cone angle of the upper cone is smaller than that of the lower cone, and both the upper and lower cones are provided with guide holes for diverting blood. A gap is provided between the opening at the top of the lower cone and the upper cone. The variable cone angle structure is suitable for a wide flow range. The guide holes of the upper and lower cones are designed with a gap to reduce blood flow dead zones and improve flow velocity stability under different flow rates.

[0016] As a further improvement to the invention, several micro-turbulence columns are distributed along the circumference within the gap. The micro-turbulence columns are hemispherical cylinders and are integrally formed with the lower cone. The micro-turbulence columns break the laminar boundary layer at the gap, avoid blood stagnation, reduce the risk of thrombosis, and do not increase the hemolysis rate.

[0017] As a further improvement to the invention, the secondary guide plate is a ring-shaped grid structure or has strip-shaped holes;

[0018] When it is a ring-shaped grid structure, it includes radial ribs and annular rings. The gap between adjacent ribs forms a diversion channel, and a multi-hole connecting ring can be provided below it. The through holes of the multi-hole connecting ring correspond to the U-shaped grooves of the three-stage guide plate.

[0019] The main diverter's guide holes, the secondary diverter's diversion channel, and the tertiary diverter's U-shaped groove form a continuous, gradually narrowing flow channel. The two structures of the secondary diverter (annular grid / strip hole) combined with the porous connecting ring achieve continuous, gradually narrowing flow channels, enhance the rectification effect, and improve blood flow uniformity.

[0020] As a further improvement to the invention, when the secondary flow guide plate is an annular grid structure, the radial ribs are evenly distributed along the circumference, and the spacing between adjacent ribs is adapted to the size of the main flow divider's flow guide hole. The rib spacing of the annular grid is adapted to the flow guide hole, ensuring smooth flow channel, further optimizing radial diffusion of blood, and improving the utilization rate of membrane module.

[0021] As a further improvement to the invention, when the secondary flow guide plate is provided with strip-shaped holes, the strip-shaped holes are evenly distributed around the circumference of the secondary flow guide plate, the hole diameter is adapted to the size of the main flow divider flow guide hole, and the size of the strip-shaped holes is adapted to the flow guide hole, reducing blood flow resistance, taking into account both the flow diversion effect and the low pressure drop requirement, and is suitable for scenarios that are sensitive to resistance.

[0022] As a further improvement to the invention, the fluid optimization structure also includes an annular filter plate located at the lower end of the oxygenation shell near the outlet blood vessel. The annular filter plate is used to intercept impurities in the blood. The annular filter plate accurately intercepts blood impurities, improves the cleanliness of the output blood, and reduces clinical complications.

[0023] As a further improvement to the invention, the annular filter plate is made of medical-grade polyethersulfone or polypropylene material, which fits tightly against the inner wall of the oxygenation shell, and the edges are rounded. The medical-grade material and rounded corner design ensure biocompatibility, reduce platelet adhesion and hemolysis, and improve the safety of use and patient tolerance.

[0024] Compared with existing technologies, the beneficial effects of the invention are as follows:

[0025] 1. This invention, through the graded flow diversion and guiding design of the biomimetic branch flow channel component, enables blood to contact the oxygenation membrane in a more uniform laminar flow state, reducing turbulence and local stagnation, and significantly improving oxygenation efficiency. At the same time, it solves the problem of uneven blood flow distribution and poor oxygenation effect in traditional structures.

[0026] 2. The annular filter plate of this invention can effectively intercept impurities in the blood. Combined with the biomimetic branched flow channel component to optimize blood flow, it reduces the risk of impurity deposition and thrombosis. At the same time, the material selection meets medical biocompatibility standards, reduces damage to blood components, and improves the safety of clinical use.

[0027] 3. This invention can meet the needs of blood flow optimization, purification or comprehensive performance in different scenarios through a variety of implementation methods, including single structure (bionic component only or filter plate only) and combined structure (both working together), and is especially suitable for a wide range of clinical scenarios from conventional extracorporeal circulation to critical care support.

[0028] 4. Through the innovative design of the fluid optimization structure, this invention achieves synergistic effects of "diversion-oxygenation-purification". Compared with traditional oxygenators, it has significant improvements in performance balance, clinical adaptability and reliability, and has outstanding technical competitive advantages. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of an embodiment of the invention. Figure 1 ;

[0030] Figure 2 This is a schematic diagram of an embodiment of the invention. Figure 2 ;

[0031] Figure 3 This is a schematic diagram of an embodiment of the invention. Figure 3 ;

[0032] Figure 4 This is a schematic diagram of an embodiment of the invention. Figure 4 ;

[0033] Figure 5 This is a schematic diagram of an embodiment of the invention. Figure 5 ;

[0034] Figure 6 This is a schematic diagram of embodiment two of the invention. Figure 1 ;

[0035] Figure 7 This is a schematic diagram of embodiment two of the invention. Figure 2 ;

[0036] Figure 8 This is a schematic diagram of embodiment two of the invention. Figure 3 ;

[0037] Figure 9 This is a schematic diagram of embodiment three of the invention. Figure 1 ;

[0038] Figure 10 This is a schematic diagram of embodiment three of the invention. Figure 2 ;

[0039] Figure 11 This is a schematic diagram of embodiment four of the invention. Figure 1 ;

[0040] Figure 12 This is a schematic diagram of embodiment four of the invention. Figure 2 ;

[0041] Figure 13 This is a schematic diagram of embodiment five of the invention.

[0042] In the diagram: 1. Blood storage cylinder; 101. Blood inlet port; 102. Sealed chamber; 103. Bleeding port; 2. Oxygenator body; 201. Oxygenation shell; 202. Upper cover; 203. Lower cover; 204. Mandrel; 3. Membrane assembly; 301. Variable temperature filament membrane structure; 302. Oxygenation filament membrane structure; 401. Bionic branch flow channel assembly; 402. Main shunt; 403. Frustum conical structure; 404. Variable cone angle frustum conical structure; 405. Upper cone; 406. Lower cone; 407. Flow guide hole; 5. Micro-turbulence column; 6. Secondary flow guide plate; 601. Annular grid structure; 602. Radial ribs; 603. Porous connecting ring; 604. Strip hole; 605. Through hole; 606. Flow channel; 7. Tertiary flow guide plate; 8. Outlet blood vessel; 9. Annular filter plate. Detailed Implementation

[0043] To facilitate understanding of the invention, a more comprehensive description of the invention will be given below with reference to the accompanying drawings, which show several embodiments of the invention. However, the invention can be implemented in different forms and is not limited to the embodiments described in the text. Rather, these embodiments are provided to make the disclosure of the invention more thorough and complete.

[0044] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. The terminology used herein in the specification of the invention is for the purpose of describing particular embodiments only and is not intended to limit the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0045] The invention will be further described in detail below with reference to the accompanying drawings.

[0046] Example 1:

[0047] Please see Figure 1-5 The invention provides an integrated membrane oxygenator, including a blood storage cylinder 1, having a closed chamber 102, with a blood inlet 101 at the upper part of the closed chamber 102 and a bleeding inlet 103 at the lower part;

[0048] The oxygenator body 2 is connected to the bleeding port 103 of the blood storage cylinder 1, and includes an oxygenation shell 201, an upper cover 202, a lower cover 203 and a spindle 204. The upper cover 202 and the lower cover 203 are respectively sealed to the upper and lower ends of the oxygenation shell 201.

[0049] Membrane module 3 is disposed inside the oxygenation shell 201 and sleeved on the outside of the mandrel 204, and includes a variable temperature filament membrane structure 301 and an oxygenation filament membrane structure 302 from the inside to the outside.

[0050] A fluid optimization structure, located within the oxygenation shell 201, is used to optimize blood flow or purify blood.

[0051] The oxygenation shell 201 is provided with an outlet vessel 8, which is located near the lower cover 203. The lower cover 203 is provided with a water inlet pipe. The top center and side wall of the upper cover 202 are respectively provided with an inlet vessel and an oxygen inlet pipe, and the inlet vessel is connected to the core shaft 204.

[0052] The fluid optimization structure also includes an annular filter plate 9, which is located at the lower end of the oxygenation shell 201 near the outlet blood vessel 8, and is used to intercept impurities in the blood.

[0053] The annular filter plate 9 is made of medical-grade polyethersulfone or polypropylene material, which fits tightly against the inner wall of the oxygenation shell 201, and the edges are rounded.

[0054] Blood enters the closed chamber 102 through the blood inlet 101 of the blood storage cylinder 1, and flows into the oxygenator body 2 through the bleeding inlet 103. It then flows sequentially through the temperature-regulating membrane structure 301 (temperature-controlled medium circulates through the water inlet pipe) and the oxygenation membrane structure 302 (oxygen is introduced through the oxygen inlet pipe) on the outside of the spindle 204, completing temperature regulation and oxygenation. Finally, when the blood flows through the annular filter plate 9, impurities with a diameter >50μm (such as microthrombi and air bubbles) are intercepted and output through the outlet vessel 8.

[0055] Example 2:

[0056] Based on Example 1, please refer to Figure 6-8 The difference between this embodiment and the first embodiment is that the annular filter plate 9 is not provided. The fluid optimization structure includes a biomimetic branch flow channel assembly 401, which is located between the spindle 204 and the membrane assembly 3. A main flow divider 402, a secondary flow guide plate 6 and a tertiary flow guide plate 7 are arranged sequentially along the blood flow direction to realize graded diversion and guidance of blood.

[0057] The main diverter 402 includes a frustum conical structure 403, and the frustum conical structure 403 is provided with a plurality of diversion holes 407 for diverting blood. The diversion holes 407 are distributed along the circumference and correspond to the diversion channel 606 of the secondary diversion plate 6.

[0058] The cone structure 403 has a cone angle of 30°, a height of 40mm, a top diameter of 25mm, a bottom diameter of 60mm, and is provided with 6 guide holes 407 (diameter of 8mm) evenly distributed along the circumference (the included angle between the centers of adjacent holes is 60°), which correspond one-to-one with the diversion channels 606 of the secondary guide plate 6.

[0059] When the secondary guide plate 6 is provided with strip-shaped holes 604, the strip-shaped holes 604 are evenly distributed around the circumference of the secondary guide plate 6, and the hole diameter is adapted to the size of the guide hole 407 of the main distributor 402.

[0060] In use, after the blood is first diverted through the main diverter 402 through the guide hole 407, it directly enters the strip hole 604 of the secondary guide plate 6. The long axis of the strip hole 604 is aligned with the direction of blood flow, reducing flow resistance. At the same time, the flow rate is increased by narrowing the orifice (8mm→6mm). After being guided by the U-shaped groove of the tertiary guide plate 7, the blood enters the membrane module 3 in a laminar flow state, completes oxygenation, and is then output. In this embodiment, the axial design of the channels avoids radial impact of the blood.

[0061] Example 3:

[0062] Based on Example 2, please refer to Figure 6 , Figure 9 , Figure 10 The difference between this embodiment and embodiment two is that the secondary guide plate 6 adopts an annular grid structure 601. When it is an annular grid structure 601, it includes radial ribs 602 and annular rings. The gap between adjacent ribs forms a diversion channel 606, and a multi-hole connecting ring 603 can be provided below it. The through hole 605 of the multi-hole connecting ring 603 corresponds to the U-shaped groove of the tertiary guide plate 7.

[0063] When the secondary guide plate 6 is an annular grid structure 601, the radial ribs 602 are evenly distributed along the circumference, and the spacing between adjacent ribs is adapted to the size of the guide hole 407 of the main distributor 402.

[0064] The main distributor 402's guide hole 407, the secondary guide plate 6's diversion channel 606, and the tertiary guide plate 7's U-shaped groove form a continuous gradually narrowing flow channel.

[0065] In use, blood enters the mandrel 204 through the inlet tube and flows downward along the inner wall of the mandrel 204. It first impacts the truncated cone surface of the main diverter 402, where it diffuses circumferentially under the guidance of the cone surface. The blood then undergoes its first diversion through the six guide holes 407, increasing the flow rate. The diverted blood then enters the grid channel of the secondary guide plate 6 and flows parallel along the inner wall of the membrane assembly 3 under the constraint of the radial ribs 602, preventing hemolysis caused by radial impact and further increasing the flow rate. After flowing out of the secondary grid, the blood undergoes a second mixing process through the porous ring (eliminating flow separation caused by rib guidance) before entering the third... The first-stage guide plate 7 improves the uniformity of flow velocity on the membrane surface. Finally, the blood is guided twice by the U-shaped groove of the third-stage guide plate 7 and enters the gap of the membrane module 3 in a laminar flow state. It makes full contact with the oxygenation fiber membrane to complete oxygenation and then exits through the outlet vessel 8. In this embodiment, the staged flow diversion makes the blood flow velocity steadily increased without the generation of turbulence, reducing the hemolysis rate. The constraint effect of the annular grid makes the blood evenly distributed along the axial direction of the membrane module 3, increasing the contact area and effectively improving the oxygenation efficiency. The 25% tapering ratio matches the radial thickness change of the membrane module 3, and the pressure drop is controlled within 1.0 kPa to meet the requirements of high flow rate use.

[0066] Example 4:

[0067] Based on Example 3, please refer to Figure 6 , Figure 11 , Figure 12 The difference between this embodiment and Embodiment 3 is that the main diverter 402 also includes a variable cone angle frustum structure 404. The variable cone angle frustum structure 404 includes an upper cone 405 and a lower cone 406. The cone angle of the upper cone 405 is smaller than that of the lower cone 406. Both the upper cone 405 and the lower cone 406 are provided with guide holes 407 for diverting blood. There is a gap between the top opening of the lower cone 406 and the upper cone 405.

[0068] The upper cone 405 has a cone angle of 15° and is provided with three inclined guide holes 407 with a diameter of 6mm; the lower cone 406 has a cone angle of 45° and is provided with three inclined guide holes 407 with a diameter of 10mm. The upper cone 405 and the lower cone 406 are nested together, with a gap of 0.5-2mm between them.

[0069] Several micro-turbulence columns 5 are distributed along the circumference within the gap. The micro-turbulence columns 5 are hemispherical cylinders and are integrally formed with the lower cone 406.

[0070] In use, after the blood enters the mandrel 204, it first flows along the inner wall of the upper cone 405 (15° small cone angle). Part of the blood undergoes initial diversion through three 6mm diameter guide holes 407, increasing the flow velocity. The remaining blood continues to flow downwards, entering the 1mm gap between the upper and lower cones 406. Due to the narrow gap, the blood velocity increases instantaneously. When flowing through several micro-turbulence columns 5, the hemispherical structure generates micro-vortices in the blood, breaking the possible laminar boundary layer. The turbulent blood then enters the lower cone 406 (45° large cone angle) region, passing through six 10mm diameter guide holes... The 407 mm guide hole achieves secondary diversion, further increasing the flow rate. The blood diverted twice converges upstream of the secondary guide plate 6, and after rectification by the grid channel, the flow rate is further increased. Finally, it is guided by the U-shaped groove of the tertiary guide plate 7 and enters the membrane module 3 in a uniform laminar flow state. In this embodiment, the variable cone angle design is suitable for a wide flow range (2-10 L / min). At low flow rates, the upper section small hole diversion is the main method, while at high flow rates, the lower section large hole participates in coordination. The segmented diversion reduces the residence time of blood on the cone surface, reduces the risk of thrombosis, and the multi-path diversion further improves the uniformity of contact with the membrane module 3.

[0071] Example 5:

[0072] Based on Example 3, please refer to Figure 1 , Figure 2 , Figure 13The difference between this embodiment and Embodiment 3 is the addition of an annular filter plate 9. Blood is first diverted through the biomimetic branched flow channel component 401 to increase the contact efficiency with the oxygenation membrane, and then impurities are intercepted by the annular filter plate 9. The final output blood has a hemolysis rate ≤0.03% and an impurity content ≤0.1mg / L. In this embodiment, by coordinating the biomimetic branched flow channel component 401 and the annular filter plate 9, a progressive treatment mechanism of "optimizing flow first and then deep purification" is formed, achieving efficient oxygenation and deep purification within a wide flow range. The hemolysis rate and system pressure drop are controlled within the ideal range. This not only solves the performance limitations of a single structure, but also improves clinical adaptability and reliability through material compatibility and modular design, meeting the dual needs of critically ill patients for efficient oxygenation and blood purification.

[0073] The invention has been described above by way of example in conjunction with the accompanying drawings. Obviously, the specific implementation of the invention is not limited to the above-described manner. Any non-substantial improvement made by adopting the inventive concept and technical solution, or the direct application of the inventive concept and technical solution to other situations without improvement, is within the scope of protection of the invention.

Claims

1. An integrated membrane oxygenator, characterized in that: It includes a blood storage cylinder (1) with a closed chamber (102), the upper part of which is provided with a blood inlet (101) and the lower part with a bleeding inlet (103); The oxygenator body (2) is connected to the bleeding port (103) of the blood storage cylinder (1), and includes an oxygenation shell (201), an upper cover (202), a lower cover (203) and a spindle (204). The upper cover (202) and the lower cover (203) are respectively sealed to the upper and lower ends of the oxygenation shell (201). The membrane module (3) is located inside the oxygenation shell (201) and sleeved on the outside of the mandrel (204), and includes a variable temperature filament membrane structure (301) and an oxygenation filament membrane structure (302) from the inside to the outside. A fluid optimization structure, located within the oxygenation shell (201), is used to optimize blood flow or purify blood. The oxygenation shell (201) is provided with an outlet vessel (8), which is located near the lower cover (203). The lower cover (203) is provided with a water inlet pipe. The top center and side wall of the upper cover (202) are respectively provided with an inlet vessel and an oxygen inlet pipe, and the inlet vessel is connected to the core shaft (204).

2. The integrated membrane oxygenator according to claim 1, characterized in that: The fluid optimization structure includes a biomimetic branch flow channel assembly (401), which is located between the mandrel (204) and the membrane assembly (3). Along the blood flow direction, a main flow divider (402), a secondary flow guide plate (6) and a tertiary flow guide plate (7) are arranged in sequence to realize the graded diversion and guidance of blood.

3. An integrated membrane oxygenator according to claim 2, characterized in that: The main diverter (402) includes a frustum-shaped structure (403), and the frustum-shaped structure (403) is provided with a plurality of diversion holes (407) for diverting blood. The diversion holes (407) are distributed along the circumference and correspond to the diversion channel (606) of the secondary diverter plate (6).

4. An integrated membrane oxygenator according to claim 2, characterized in that: The main shunt (402) also includes a variable cone angle frustum structure (404), which includes an upper cone (405) and a lower cone (406). The cone angle of the upper cone (405) is smaller than that of the lower cone (406), and both the upper cone (405) and the lower cone (406) are provided with guide holes (407) for diverting blood. A gap is provided between the top opening of the lower cone (406) and the upper cone (405).

5. An integrated membrane oxygenator according to claim 4, characterized in that: Several micro-turbulence columns (5) are distributed along the circumference within the gap. The micro-turbulence columns (5) are hemispherical cylinders and are integrally formed with the lower cone (406).

6. An integrated membrane oxygenator according to claim 1, characterized in that: The secondary guide plate (6) is an annular grid structure (601) or has strip holes (604); When it is an annular grid structure (601), it includes radial ribs (602) and annular rings. The gap between adjacent ribs forms a diversion channel (606), and a multi-hole connecting ring (603) can be provided below it. The through hole (605) of the multi-hole connecting ring (603) corresponds to the U-shaped groove of the three-stage guide plate (7). The guide hole (407) of the main distributor (402), the diversion channel (606) of the secondary guide plate (6), and the U-shaped groove of the tertiary guide plate (7) form a continuous gradually narrowing flow channel.

7. An integrated membrane oxygenator according to claim 6, characterized in that: When the secondary guide plate (6) is an annular grid structure (601), the radial ribs (602) are evenly distributed along the circumference, and the spacing between adjacent ribs is adapted to the size of the guide hole (407) of the main distributor (402).

8. An integrated membrane oxygenator according to claim 6, characterized in that: When the secondary guide plate (6) is provided with strip holes (604), the strip holes (604) are evenly distributed around the circumference of the secondary guide plate (6), and the hole diameter is adapted to the size of the guide hole (407) of the main distributor (402).

9. An integrated membrane oxygenator according to claim 1, characterized in that: The fluid optimization structure also includes an annular filter plate (9), which is located at the lower end of the oxygenation shell (201) near the outlet blood vessel (8) and is used to intercept impurities in the blood.

10. An integrated membrane oxygenator according to claim 9, characterized in that: The annular filter plate (9) is made of medical grade polyethersulfone or polypropylene material, which fits tightly against the inner wall of the oxygenation shell (201), and the edges are rounded.

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