Antibodies or antigen-binding fragments thereof against porcine b-cell surface cd20 and compositions and uses thereof

By preparing a monoclonal antibody against CD20 on the surface of porcine B cells, the problem of lacking recognition of CD20 on the surface of porcine cells in the existing technology has been solved, achieving high affinity and bioactivity, and supporting disease diagnosis and treatment in porcine biomedical models.

CN120965882BActive Publication Date: 2026-04-21INST OF HEALTH & MEDICINE HEFEI COMPREHENSIVE NAT SCI CENT
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Patent Information

Application Number
CN202511176106.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-08-21
Publication Date
2026-04-21
Estimated Expiration
2045-08-21

AI Technical Summary

Technical Problem

The lack of monoclonal antibodies that recognize CD20 on the surface of pig cells in existing technologies makes it difficult to apply them to pig biomedical models and disease diagnosis. Furthermore, the types of existing antibodies are limited and expensive.

Method used

Monoclonal antibodies or antigen-binding fragments of porcine B cell surface CD20 have been developed, possessing specific HCDR and LCDR sequences, including Fab fragments, Fab'-SH fragments, Fv fragments, scFv fragments, F(ab')2 fragments, etc. They are prepared using recombinant protein expression and purification techniques and are suitable for eukaryotic and prokaryotic cell expression systems.

Benefits of technology

This study provides antibodies with high affinity and bioactivity against CD20 on the surface of porcine B cells, enabling specific binding and sorting of porcine B cells and supporting the development of disease diagnosis and treatment methods.

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Abstract

This invention provides antibodies against CD20 on the surface of porcine B cells, or antigen-binding fragments thereof, as well as compositions thereof and their applications. Specifically, it provides an antibody pCD20Ab3 against CD20 on the surface of porcine B cells, or an antigen-binding fragment thereof, which can effectively bind to CD20 on the surface of porcine B cells. This invention also provides antibody-drug conjugates containing this antibody or its antigen-binding fragment, which can be used for screening porcine B cells and have good application prospects.
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