A nano-enzyme cross-linked polyprionic acid-based hydrogel adhesive as well as preparation and application thereof
The preparation of polythioctic acid-based hydrogels by nanozyme crosslinking solves the problems of poor mechanical properties and insufficient antibacterial properties of PTA-based hydrogels, achieving rapid hemostasis and wound sealing, and promoting wound healing.
CN121003725BActive Publication Date: 2026-08-25WUHAN UNIV OF TECH
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Patent Information
- Application Number
- CN202511077154.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-01
- Publication Date
- 2026-08-25
- Estimated Expiration
- 2045-08-01
AI Technical Summary
Technical Problem
Existing PTA-based hydrogels have poor mechanical properties and insufficient antibacterial properties, making them unable to effectively control bleeding from deep, irregularly shaped wounds, prolonging healing time and increasing the risk of infection.
Method used
By preparing nanozyme-crosslinked polythioctic acid-based hydrogels, a dual network structure is formed between caffeic acid-silver nanozyme and sericin. Lithium hydroxide is used to adjust pH and temperature, thereby enhancing the mechanical properties and antibacterial ability of the hydrogel.
Benefits of technology
It achieves excellent wet adhesion properties, significant antibacterial properties and good biocompatibility of hydrogel, and can quickly stop bleeding, seal wounds and promote wound healing.
✦ Generated by Eureka AI based on patent content.
Abstract
The application discloses a nano-enzyme cross-linked polysulfooxynic acid-based hydrogel adhesive as well as a preparation method and application thereof, wherein the preparation method comprises the following steps: dissolving caffeic acid in ethanol to obtain a caffeic acid solution, adding an AgNO3 solution into the caffeic acid solution, and stirring and reacting to prepare caffeic acid-silver nano-enzymes; adding sulfooxynic acid and silk fibroin into an aqueous solution of lithium hydroxide in sequence, and then adding the caffeic acid-silver nano-enzymes into the mixture, stirring and mixing to form a gel, and obtaining the hydrogel adhesive after cooling. The hydrogel provided by the application has excellent wet adhesion, remarkable antibacterial property, good mechanical property and biocompatibility, these properties enable the hydrogel to provide a good repair environment for a wound and provide effective antibacterial treatment, thereby being beneficial to the rapid healing of a traumatic wound, and having a very good application prospect in the field of wound repair.
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