A head-mounted phototherapy system for prefrontal brain regions

Abstract

The application relates to the technical field of medical instruments, in particular to a head-mounted phototherapy system for frontal lobe brain areas, which comprises an information acquisition unit, a signal processing unit, an information output unit and a head fixing device; the information acquisition unit is used for acquiring physiological signals, physical signals and optical signals in a treatment process; the signal processing unit is used for receiving and processing signals sent by the information acquisition unit, generating light parameter control instructions and fixing device adjustment instructions according to a processing result, and sending the instructions to the information output unit; the information output unit converts the instructions into corresponding treatment schemes to implement treatment, and sends adjustment instructions to the head fixing device; the head fixing device is fixed on a forehead part of a user, and adjusts a self state according to the adjustment instructions of the information output unit to adapt to the user; the application aims to realize the target of long-term home treatment of patients with central nervous system diseases, thereby reducing treatment cost, improving treatment efficiency and having a good application prospect.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a head-mounted phototherapy system targeting the prefrontal cortex. Background Technology

[0002] Transcranial photobiomodulation (tPBM), as a non-invasive neuromodulation technique, has shown remarkable potential in the treatment of central nervous system diseases, particularly those related to the prefrontal cortex (PFC), such as depression, Alzheimer's disease, Parkinson's disease, post-traumatic stress disorder (PTSD), and sleep disorders. Its therapeutic mechanism is based on the penetration of 630-1064nm near-infrared light into the skull to activate mitochondrial cytochrome c oxidase in the PFC region, synergistically repairing the condition through three pathways: ① promoting neuronal ATP synthesis to enhance metabolic activity; ② inhibiting the release of neuroinflammatory factors such as TNF-α and IL-6; and ③ improving local cerebral blood flow and oxygenation levels, thereby remodeling neural activity.

[0003] However, existing tPBM devices have structural defects in key dimensions of clinical application: traditional headbands or adhesive patches are prone to displacement errors due to facial movements and sweat secretion, causing the light spot to deviate from the designated PFC functional subregion (e.g., the dorsolateral PFC is responsible for cognitive regulation, and the ventromedial PFC regulates emotion), making it difficult to ensure the long-term stability and continuity of phototherapy; in terms of light source design, existing devices usually use several LEDs with fixed power to irradiate a large area with a single wavelength. Large-area fixed-wavelength LED arrays cannot adapt to individual differences in frontal skull thickness (4-12mm) and hairline obstruction, easily causing epidermal heat accumulation (risk of burns >41℃) and insufficient penetration into deep brain regions (light attenuation rate >90%). At the same time, existing products mostly adopt static parameter output schemes, ignoring the specific needs of disease stages (anti-inflammatory wavelengths are needed in the acute phase, and neuroregeneration bands are needed in the chronic phase), and lack physiological feedback loops, resulting in poor consistency of efficacy. The industry has long been caught in a dilemma where stability, precision, and comfort are mutually exclusive: strong fixation structures (such as strap helmets) induce nerve compression headaches; lightweight patches accelerate adhesive failure due to poor breathability; and broad-spectrum irradiation techniques ignore the functional differentiation of PFC subregions. This technological gap severely restricts the widespread application of tPBM in central nervous system diseases requiring long-term intervention.

[0004] Therefore, there is an urgent need in this field for a head-mounted phototherapy system targeting the prefrontal cortex that can (1) achieve millimeter-level displacement tolerance with zero skin pressure to ensure precise targeting of the PFC subregion; (2) dynamically balance light penetration efficiency and thermal risk to adapt to individual anatomical differences; and (3) construct a multispectral switching and physiological feedback closed loop to meet the needs of adaptive treatment at different disease stages. Summary of the Invention

[0005] To address or partially address the problems existing in related technologies, this application provides a head-mounted phototherapy system targeting the prefrontal cortex, aiming to achieve the goal of long-term home-based treatment for patients with central nervous system diseases, thereby reducing treatment costs and improving treatment efficiency.

[0006] This application provides a head-mounted phototherapy system for the prefrontal cortex, comprising: an information acquisition unit, a signal processing unit, an information output unit, and a head fixation device;

[0007] The information acquisition unit is connected to the signal processing unit and is used to acquire physiological signals, physical signals and optical signals during the treatment process, and send the acquired signals to the signal processing unit.

[0008] The signal processing unit is connected to the information acquisition unit and the information output unit respectively. It is used to receive and process the signals sent by the information acquisition unit, generate optical parameter adjustment instructions and fixing device adjustment instructions according to the processing results, and send the instructions to the information output unit.

[0009] The information output unit is connected to the signal processing unit and the head fixation device respectively, and is used to receive the instructions sent by the signal processing unit, convert the instructions into corresponding treatment plans for implementation, and send adjustment instructions to the head fixation device.

[0010] The head fixation device is connected to the information output unit and is used to encapsulate the information acquisition unit, the signal processing unit, and the information output unit into a whole, fix it on the user's forehead, and adjust its own state according to the adjustment instructions of the information output unit to adapt to the user.

[0011] The technical solution provided in this application may include the following beneficial effects:

[0012] This application provides transcranial phototherapy for central nervous system diseases affecting the prefrontal cortex, with temperature warning to prevent damage to patients, thus offering a new non-invasive treatment method. It utilizes multi-band light sources, where longer wavelengths offer better penetration and can treat deeper brain regions, while shorter wavelengths have better absorption by brain tissue. The combination of multiple bands compensates for each other's shortcomings, achieving optimal therapeutic effects. The phototherapy module covers the prefrontal region. Since the frontal lobe is closely related to patients' cognition, memory, and emotions, photobiological modulation of the nerves in this area can improve neural activity and alleviate disease symptoms. This application enables long-term home-based treatment, significantly reducing treatment costs and improving efficiency, demonstrating promising application prospects.

[0013] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0014] The above and other objects, features and advantages of this application will become more apparent from the more detailed description of exemplary embodiments thereof in conjunction with the accompanying drawings, wherein the same reference numerals generally represent the same components in the exemplary embodiments thereof.

[0015] Figure 1 This is a schematic diagram of the structure of a head-mounted phototherapy system targeting the prefrontal cortex, as shown in an embodiment of this application.

[0016] Figure 2 This is a schematic diagram illustrating the working principle of a head-mounted phototherapy system targeting the prefrontal cortex, as shown in an embodiment of this application.

[0017] Figure 3 This is a schematic diagram of the illumination surface of a head-mounted phototherapy system targeting the prefrontal cortex, as shown in an embodiment of this application.

[0018] Figure 4 This is a frontal view of a head-mounted phototherapy system targeting the prefrontal cortex, as shown in an embodiment of this application.

[0019] Figure 5 This is a side view of a head-mounted phototherapy system targeting the prefrontal cortex, as shown in an embodiment of this application.

[0020] In the diagram, 1 is the information acquisition unit; 2 is the signal processing unit; 3 is the information output unit; 4 is the head fixation device; 11 is the EEG acquisition device; 12 is the temperature acquisition device; 13 is the pressure acquisition device; 14 is the diffuse light acquisition device; 31 is the illumination module; 32 is the filter; 33 is the heat dissipation module; 41 is the strap; 42 is the motor; 43 is the airbag; and 44 is the magnetic interface. Detailed Implementation

[0021] Embodiments of this application will now be described in more detail with reference to the accompanying drawings. While embodiments of this application are shown in the drawings, it should be understood that this application may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to make this application more thorough and complete, and to fully convey the scope of this application to those skilled in the art.

[0022] The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The singular forms “a,” “the,” and “the” used in this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term “and / or” as used herein refers to and includes any or all possible combinations of one or more of the associated listed items.

[0023] It should be understood that although the terms "first," "second," "third," etc., may be used in this application to describe various information, this information should not be limited to these terms. These terms are only used to distinguish information of the same type from one another. For example, without departing from the scope of this application, first information may also be referred to as second information, and similarly, second information may also be referred to as first information. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0024] The technical solutions of the embodiments of this application are described in detail below with reference to the accompanying drawings.

[0025] Example 1:

[0026] Please see Figure 1-5 This embodiment provides a head-mounted phototherapy system targeting the prefrontal cortex, including an information acquisition unit 1, a signal processing unit 2, an information output unit 3, and a head fixation device 4.

[0027] The information acquisition unit 1 is connected to the signal processing unit 2 and is used to acquire physiological signals, physical signals and optical signals during the treatment process, and send the acquired signals to the signal processing unit 2.

[0028] The signal processing unit 2 is connected to the information acquisition unit 1 and the information output unit 3 respectively. It is used to receive the signal sent by the information acquisition unit 1 and process it. Based on the processing result, it generates optical parameter adjustment instructions and fixing device adjustment instructions and sends the instructions to the information output unit 3.

[0029] The information output unit 3 is connected to the signal processing unit 2 and the head fixation device 4 respectively. It is used to receive the instructions sent by the signal processing unit 2, convert the instructions into corresponding treatment plans for treatment, and send adjustment instructions to the head fixation device 4.

[0030] The head fixation device 4 is connected to the information output unit 3 and is used to encapsulate the information acquisition unit 1, the signal processing unit 2, and the information output unit 3 into a whole, fix it on the user's forehead, and adjust its own state according to the adjustment instructions of the information output unit 3 to adapt to the user.

[0031] In this embodiment, the information acquisition unit 1, signal processing unit 2, information output unit 3, and head fixation device 4 of the head-mounted phototherapy system work together. First, the user wears the head fixation device 4 on their forehead, ensuring that it encapsulates the other three units into a whole and fixes them stably. During treatment, the information acquisition unit 1 collects the patient's electroencephalogram (EEG) signals (physiological signals), forehead skin temperature, pressure signals (physical signals), and skin reflected light intensity signals (optical signals) in real time, and transmits these signals to the signal processing unit 2. The signal processing unit 2 analyzes and processes the received signals, assesses the patient's current neurological state based on the EEG signals, calculates the required light irradiation parameters by combining the temperature signal and the reflected light intensity signal, and generates light parameter adjustment instructions (such as setting 810nm pulsed light with an intensity of 35mW / cm). 2 The system receives the commands (frequency 10Hz) and the fixation device adjustment commands (such as maintaining the current pressure of the airbag 43), and then sends the commands to the information output unit 3. After receiving the commands, the information output unit 3 controls the light module 31 to output light for treatment according to the light parameter adjustment commands. At the same time, it sends the fixation device adjustment commands to the head fixation device 4. The head fixation device 4 maintains its own stable state according to the commands, ensuring that the device fits the user's forehead during the treatment process and achieves precise phototherapy.

[0032] In one embodiment, the information acquisition unit 1 includes an EEG acquisition device 11, a temperature acquisition device 12, a pressure acquisition device 13, and a diffuse reflection light acquisition device 14; the EEG acquisition device 11 is used to acquire the user's EEG signals, the temperature acquisition device 12 is used to acquire the user's forehead skin temperature signals, the pressure acquisition device 13 is used to acquire the contact pressure signals between the head fixation device 4 and the user's head, and the diffuse reflection light acquisition device 14 is used to acquire the intensity signals of reflected light from the user's forehead skin.

[0033] The diffuse reflection light acquisition device 14 synchronously monitors the tissue optical parameters and transmits the tissue optical parameters, along with the electroencephalogram (EEG) signal, temperature signal, pressure signal, and forehead skin reflectance intensity signal, to the signal processing unit 2 for the signal processing unit 2 to calculate the actual irradiation dose.

[0034] In this embodiment, the information acquisition unit 1 includes two sets of diffuse reflection light acquisition devices 14, which can use photodiodes placed in the center area of ​​the forehead. Each set of optical acquisition modules can acquire reflected light parameters.

[0035] Information acquisition unit 1 can acquire physiological signals (electroencephalogram signals R) in real time. EEG ), physical signals (skin temperature T) s Contact pressure P c ) and optical signals (skin reflected light intensity I) r The signal processing unit 2 calculates the actual irradiation dose D and the light source-skin distance d based on this signal;

[0036] The signal processing unit 2 evaluates the light treatment effect in real time through an embedded algorithm, and sends instructions to adjust the light frequency, intensity and shape to the information output unit 3 according to the evaluation results.

[0037] Specifically, the embedded algorithm is used to solve the problem of accurately delivering light therapy energy to the prefrontal brain region. The specific logic is as follows:

[0038] The skin reflected light intensity I obtained by the diffuse reflection light acquisition device 14 in the information acquisition unit 1 r , the initial light intensity I0 of the light source, and the absorbed light I calculated through tissue optical parameters a ;

[0039] Invert the actual light penetration depth d through a preset light attenuation model. The formula is:

[0040]

[0041] Among them, μ is the light attenuation coefficient, and a basic value needs to be preset in combination with the characteristics of the prefrontal brain tissue, and then dynamically corrected through real-time reflected light data. The correction process is a well-known method and will not be elaborated in detail;

[0042] Further derive the actual irradiation dose D received by the brain tissue, provide a dose reference for subsequent light parameter adjustment, introduce physiological / physical signals for weighted calibration, and ensure that the irradiation dose D fits the actual situation of the individual. The formula is:

[0043]

[0044] In the formula, α is the system calibration constant; d is the actual light penetration depth mentioned above, d0 is the standard depth of the target brain region, preset based on the targeting requirements of the prefrontal sub-region, β is the correction coefficient weight, calibrated through previous experiments; ω1, ω2, ω3, ω4 are the weighted coefficients of electroencephalogram signal, skin reflected light intensity, pressure, and temperature preset based on previous experimental tests; when the pressure is abnormal (such as the loosening of the airbag 43 causes P c to drop), the temperature is too high (T s is close to the 41°C safety threshold), the algorithm will automatically correct the D value to avoid the risk of insufficient dose or thermal damage; The logic of the term is that when d = d0 (the penetration depth just meets the standard), it does not affect the original D value; when d > d0 (the penetration is too deep), moderately increase D to match the deep absorption; when d < d0 (the penetration is insufficient), reduce D to avoid overheating caused by excessive absorption of the surface skin;

[0045] In one embodiment, the system receives the raw signal from the EEG acquisition device 11 and determines whether the current phototherapy is effective by using preset thresholds (such as prefrontal alpha wave asymmetry, theta wave power ratio, etc., corresponding to the neuroelectrophysiological characteristics of different diseases such as depression and Alzheimer's disease). For example, in the treatment of depression, a decrease in alpha wave asymmetry is considered to have achieved the therapeutic effect.

[0046] If the therapeutic effect is not satisfactory or abnormalities occur (such as EEG signals showing excessive neural excitation), the algorithm will send instructions to information output unit 3 to dynamically adjust the following parameters:

[0047] Light intensity (e.g., from 35mW / cm) 2 Increased to 40mW / cm 2 );

[0048] Light frequency (e.g., switching from 10Hz pulse to 50Hz pulse, or switching to continuous light);

[0049] Spot shape / wavelength (e.g., when targeting the ventral medial PFC, an elliptical spot is output; when treating Alzheimer's disease, switch to 1064nm near-infrared light);

[0050] Meanwhile, the embedded algorithm not only focuses on the phototherapy dosage, but also adjusts the device status through pressure / temperature signals to balance fit and comfort; that is, it provides the contact pressure signal P from the receiving pressure acquisition device 13. c If P c If the value is lower than the preset value (e.g., airbag 43 is loose), a command is sent to the head restraint device 4 to control the motor 42 to tighten the nylon strap 41 or inflate the airbag 43; if P c If the temperature exceeds the preset value (e.g., due to pressure causing discomfort), the system instructs the deflation or loosening of the strap 41; it also receives the skin temperature T from the temperature acquisition device 12. s Signal, when T s When the temperature exceeds 39℃, the cooling module's fan power is 33 liters; when T s When the temperature reaches ≥41℃, immediately send a stop phototherapy command to prioritize safety.

[0051] In one embodiment, the EEG acquisition device 11 includes at least one of dry electrodes, semi-dry electrodes, or wet electrodes, and the various types of electrodes are interchangeable to adapt to different usage scenarios and user needs.

[0052] The EEG acquisition device 11 uses three electrode pads, which are in close contact with the body surface.

[0053] In one embodiment, the information output unit 3 includes a light irradiation module 31, a heat dissipation module 33, and a communication module; the light irradiation module 31 is used to output light of different wavelengths to implement treatment, the heat dissipation module 33 is used to control the temperature of the device, and the communication module is used to establish a connection with a smart terminal to realize information interaction.

[0054] The illumination module 31 supports wavelength switching. By changing the light source combination or using the filter 32, it outputs 430-780nm visible light or 780-1100nm near-infrared light. It also adjusts the shape and spatial distribution of the light spot according to the instructions of the signal processing unit 2 to ensure targeted coverage of the prefrontal subregion.

[0055] The heat dissipation module 33 adopts active air cooling to control the temperature, which is controlled by the signal processing unit 2. When the temperature acquisition device 12 detects that the user's forehead skin temperature is close to or exceeds the preset threshold, the signal processing unit 2 controls the heat dissipation module 33 to increase the heat dissipation power to maintain the skin temperature ≤41℃; when the temperature exceeds 41℃, the signal processing unit 2 controls the light irradiation module 31 to stop phototherapy.

[0056] The communication module is used to establish a connection with smart terminals, including but not limited to smartphones and computers. Smartphones need to have basic functions such as an Android system, Bluetooth communication capability, touch screen, and speaker. Users can adjust the phototherapy power in the transcranial phototherapy unit (adjustment range: 0-50mW / cm). 2 The system allows users to set the light therapy duration (adjustable range: 0-60 min) and switch between continuous light and pulsed light therapy modes. When pulsed light therapy is selected, users can adjust the pulsed light power (adjustable range: 0-50 Hz). During light therapy, users can monitor changes in electroencephalogram (EEG) data via a smart terminal. After each light therapy session, users can view physiological data changes.

[0057] The steps for using a smart terminal to perform transcranial phototherapy are as follows:

[0058] 1) Use a smart device to start the phototherapy equipment; the equipment will then begin operation.

[0059] 2) Access the smart terminal, set the treatment time and light power, click "Start Treatment" to start the phototherapy device for phototherapy;

[0060] 3) Monitor physiological data changes in real time during phototherapy;

[0061] 4) After phototherapy is completed, you can check the treatment effect after previous phototherapy sessions. Use this as a standard to evaluate the efficacy of phototherapy and adjust the parameters of the next phototherapy session to achieve better treatment results.

[0062] Specifically, the optical power range of the illumination module 31 is 0-50mW / cm². 2It can switch between continuous light therapy and 0-1kHz pulsed light therapy. The temperature warning module is located in the center of the system's edge. When the user's scalp temperature is higher than 39°C, the heat dissipation system power is increased, and when the temperature reaches 41°C, the light therapy will be stopped immediately. The system includes a basic circuit system and a battery system, with the battery system powering the device.

[0063] In one embodiment, the head fixation device 4 includes a base layer, a contact layer, and a functional layer; the base layer is a nylon or rubber strap 41, which provides support for the main body and receives instructions from the information output unit 3 to adjust the length of the strap 41 via a motor 42 to change the tightness of the fixation; the contact layer is an inflatable airbag 43 made of natural or synthetic rubber, which is used to automatically inflate and deflate to conform to the curvature of the human forehead and also serves as a light-proof sealing function; the functional layer is provided with a magnetic interface 44 or a socket for fixing and supporting the quick replacement of the light module 31 and the filter 32.

[0064] In this embodiment 1, the information output unit 3 can connect to the intelligent control unit via Bluetooth / Wifi communication module to issue work instructions or receive feedback information sent by the intelligent terminal (mobile phone / computer). The information output unit 3 performs transcranial phototherapy for central nervous system diseases affecting the prefrontal cortex, and provides temperature warning and eye protection to avoid damage to the patient from phototherapy, thus providing a new non-invasive treatment method for the patient. This embodiment 1 uses multi-band light sources for treatment, where longer wavelength light sources have better penetration and can treat deep brain regions, while shorter wavelength light sources have better absorption of brain tissue. The combination of multi-band light can compensate for each other's deficiencies and achieve the best treatment effect. The phototherapy module covers the prefrontal region. Since the frontal lobe of the brain is related to the patient's cognition, memory, and emotions, phototherapy to this area can achieve better therapeutic effects for most patients with central nervous system diseases. Therefore, this embodiment can achieve the goal of long-term home treatment for patients, which can greatly reduce treatment costs, improve treatment efficiency, and has good application prospects.

[0065] Example 2:

[0066] This embodiment is applied to a depression treatment scenario. Before phototherapy, the user needs to wear the head fixation device 4 on their forehead, ensuring that the airbag 43 completely covers the area from the brow bone to the hairline. The electrode pads (dry electrode type) must be in close contact with the skin (impedance <50kΩ). The mobile APP connects to the device via Bluetooth, and the "Depression Treatment Mode" is selected; the signal processing unit 2 analyzes the asymmetry of the alpha waves in the left and right frontal lobes in real time: the light module 31 begins to output 810nm pulsed light (intensity 35mW / cm²). 2(Frequency 10Hz); Signal processing unit 2 synchronously adjusts the light spot to an elliptical shape (major axis 30mm, minor axis 20mm) to target the ventral medial PFC; alpha wave asymmetry decreases, maintaining the treatment plan unchanged; During treatment, diffuse reflection light acquisition device 14 detects a 20% decrease in reflectivity due to sweat, and the light intensity is automatically compensated to 40mW / cm². 2 When the temperature acquisition device 12 detects a local hot spot temperature >38℃, it starts the cooling fan (power 1W) and adjusts the light intensity attenuation by 10%; when the treatment ends, the light source gradually dims and is turned off, and the airbag 43 slowly depressurizes.

[0067] Example 3:

[0068] This embodiment is applied to Alzheimer's disease treatment. Before phototherapy, the user needs to wear the system on their head. When wearing it, the user must input their age (75 years old) in the app, and the system automatically loads an elderly head tissue model. The magnetic light source module is pre-installed with an OLED light source. The airbag is inflated to 3 kPa (low-pressure mode), and the tightness of the strap is automatically adjusted. For the first 20 minutes, it outputs 670nm red light (20mW / cm²). 2 Stimulate the lateral dorsolateral PFC; 40 minutes later, switch to 1064nm near-infrared light (30mW / cm²). 2 (), penetrating deep layers; the diffuse reflection light acquisition device 14 calculates the actual cortical light dose in real time. If the calculated value is <40J / cm 2 Increase light intensity to 35mW / cm 2 When the temperature is >38℃, start the cooling fan (1W power) and adjust the light intensity to decrease by 10%; after treatment, generate a treatment report and push it to the mobile phone.

[0069] The various embodiments of this application have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or improvement of the technology in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A head-mounted phototherapy system for prefrontal brain regions, characterized by, include: Information acquisition unit, signal processing unit, information output unit, and head fixation device; The information acquisition unit is connected to the signal processing unit and is used to acquire physiological signals, physical signals and optical signals during the treatment process, and send the acquired signals to the signal processing unit. The information acquisition unit includes an EEG acquisition device, a temperature acquisition device, a pressure acquisition device, and a diffuse reflection light acquisition device for acquiring the intensity signal of reflected light from the user's forehead skin. The diffuse reflection light acquisition device simultaneously monitors tissue optical parameters and transmits the tissue optical parameters, along with the EEG signal, temperature signal, pressure signal, and intensity signal of reflected light from the forehead skin, to the signal processing unit for the signal processing unit to calculate the actual irradiation dose. The signal processing unit is connected to the information acquisition unit and the information output unit respectively. It is used to receive and process the signals sent by the information acquisition unit, generate optical parameter adjustment instructions and fixing device adjustment instructions according to the processing results, and send the instructions to the information output unit. The information output unit is connected to the signal processing unit and the head fixation device respectively, and is used to receive the instructions sent by the signal processing unit, convert the instructions into corresponding treatment plans for implementation, and send adjustment instructions to the head fixation device. The head fixation device is connected to the information output unit and is used to encapsulate the information acquisition unit, the signal processing unit, and the information output unit into a whole, fix it on the user's forehead, and adjust its own state according to the adjustment command of the information output unit to adapt to the user. The signal processing unit uses an embedded algorithm to evaluate the effect of light therapy in real time, and sends instructions to the information output unit to adjust the light frequency, intensity and shape based on the evaluation results. The logic of the embedded algorithm includes: The diffuse reflection light acquisition device obtains the skin reflected light intensity, the initial light intensity of the light source, and the absorbed light calculated through tissue optical parameters, and inverts the actual light penetration depth through a preset light attenuation model; The actual penetration depth of light is inverted through the preset light attenuation model , and the formula is: ； wherein, is the optical attenuation coefficient, is the intensity of the reflected light from the skin, is the initial light intensity of the light source, is the absorbed light intensity; The actual radiation dose received by brain tissue is derived and automatically corrected to ensure that the radiation dose matches the individual's actual situation. The formula for radiation dose is: ； In the formula, is the irradiation dose, is the electroencephalogram signal, is the skin reflected light intensity, is the contact pressure, is the epidermal temperature; is the system calibration constant; is the actual penetration depth of the light, is the standard depth of the target brain area, is the correction coefficient weight, calibrated by the previous experiment; , , , are the weighting coefficients of the electroencephalogram signal, the skin reflected light intensity, the pressure, and the temperature, respectively, which are preset based on the previous experimental test. The system receives raw signals from the EEG acquisition device and determines whether the current phototherapy is effective based on preset thresholds. If the therapeutic effect is not up to standard or an abnormality occurs, the algorithm sends instructions to the information output unit to dynamically adjust the light intensity, light frequency, and light spot shape / wavelength.

2. The head-mounted phototherapy system for prefrontal brain regions of claim 1, wherein, The EEG acquisition device is used to acquire the user's EEG signals, the temperature acquisition device is used to acquire the user's forehead skin temperature signals, and the pressure acquisition device is used to acquire the contact pressure signals between the head fixation device and the user's head.

3. The head-mounted phototherapy system for the frontal lobe brain region of claim 2, wherein, The EEG acquisition device includes at least one of dry electrodes, semi-dry electrodes, or wet electrodes, and the various types of electrodes can be interchanged to adapt to different usage scenarios and user needs.

4. The head-mounted phototherapy system for prefrontal brain regions of claim 1, wherein, The information output unit includes a light illumination module, a heat dissipation module, and a communication module; the light illumination module is used to output light of different wavelengths for treatment, the heat dissipation module is used to control the temperature of the device, and the communication module is used to establish a connection with a smart terminal to realize information interaction.

5. The head-mounted phototherapy system for the frontal lobe brain region of claim 4, wherein, The illumination module supports wavelength switching. By changing the light source combination or using filter switching, it outputs 430-780nm visible light or 780-1100nm near-infrared light. It also adjusts the shape and spatial distribution of the light spot according to the instructions of the signal processing unit to ensure targeted coverage of the prefrontal subregion.

6. The head-mounted phototherapy system for prefrontal brain regions of claim 4, wherein, The heat dissipation module uses active air cooling to control the temperature, which is controlled by the signal processing unit. When the temperature acquisition device detects that the user's forehead skin temperature is close to or exceeds a preset threshold, the signal processing unit controls the heat dissipation module to increase the heat dissipation power to maintain the skin temperature ≤41℃; when the temperature exceeds 41℃, the signal processing unit controls the light irradiation module to stop phototherapy.

7. The head-mounted phototherapy system for the prefrontal cortex according to claim 1, characterized in that, The head fixation device includes a base layer, a contact layer, and a functional layer. The base layer is a nylon or rubber strap, which provides support for the main body and receives instructions from the information output unit to adjust the strap length via a motor to change the tightness of the fixation. The contact layer is an inflatable airbag made of natural or synthetic rubber, which automatically inflates and deflates to conform to the curvature of the human forehead and also serves as a light-proof seal. The functional layer is equipped with a magnetic interface or socket for fixing and supporting the quick replacement of the light module and filter.

8. The head-mounted phototherapy system for the prefrontal cortex region according to claim 1, characterized in that, The signal processing unit also includes adjusting the state of the head fixation device based on the pressure signal acquired by the pressure acquisition device, balancing fit and comfort.

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