A herpes zoster vaccine composition and a method of preparing the same

By optimizing the composition and surface modification of liposome membranes, and combining gE protein and multiple adjuvants, the stability and activity of antigens during preparation, storage and reconstitution were solved, improving the shelf-life stability and delivery efficiency of the shingles vaccine and ensuring its effectiveness.

CN121243360BActive Publication Date: 2026-03-17JIANGSU WALVAX BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511831939.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-12-08
Publication Date
2026-03-17
Estimated Expiration
2045-12-08

AI Technical Summary

Technical Problem

In existing technologies, antigens face challenges in maintaining structural stability and activity during preparation, storage, and reconstitution, particularly in the issue of compatibility inactivation when antigens coexist with liposomes for extended periods, which affects shelf-life stability and delivery efficiency.

Method used

By optimizing the composition and surface modification of liposome membranes, a herpes zoster vaccine composition was prepared using gE protein and adjuvant combinations, including aluminum salt adjuvants, saponin adjuvants, TLR pathway agonists, STING pathway agonists, emulsion adjuvants, and liposome adjuvants, combined with buffers, stabilizers, surfactants, isotonic modifiers, preservatives, chelating agents, and antioxidants. Specific preparation methods were used to improve the uptake and delivery efficiency of antigen-presenting cells.

Benefits of technology

This approach achieves structural stability and activity retention of the antigen during storage and reconstitution, improves shelf-life stability, and enhances the uptake and delivery efficiency of antigen-presenting cells, thus ensuring vaccine efficacy.

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Abstract

The application discloses a zoster vaccine composition and a preparation method, and belongs to the technical field of vaccines.The zoster vaccine composition comprises gE protein and an adjuvant; the adjuvant is at least one selected from aluminum salt adjuvants, saponin adjuvants, TLR pathway agonists, STING pathway agonists, emulsion adjuvants and liposome adjuvants.The application also provides a preparation method thereof.Compared with the prior art, the prepared gE protein is jointly constructed with a glassy sugar and a buffer system to form a protective matrix, hydrogen bonds are replaced and a fixed conformation is glassified during freezing and drying, interface-induced unfolding and aggregation are reduced, a small amount of surfactant weakens air-liquid and solid-liquid interfacial tension, terminal low adsorption filtration reduces non-specific adsorption loss, and a monomer state and immunogenicity are maintained after reconstitution.
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