Application of lasiokaurin and cis-platinum combined drug in preparation of liver cancer treatment drug

The combined use of tannin and cisplatin in the treatment of liver cancer has solved the problem of cisplatin resistance in liver cancer patients by inhibiting the proliferation, migration and invasion of liver cancer cells, providing a more effective treatment method and product, and improving the treatment effect of liver cancer.

CN121265636APending Publication Date: 2026-01-06TAIZHOU TRADITIONAL CHINESE MEDICINE HOSPITAL +1
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Patent Information

Application Number
CN202511647043.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-11
Publication Date
2026-01-06

AI Technical Summary

Technical Problem

In the current technology, liver cancer patients develop resistance to cisplatin chemotherapy drugs, leading to reduced treatment efficacy and increased risk of recurrence. There is a lack of effective combination therapy regimens to overcome this problem.

Method used

The combination of tamarind and cisplatin was used to prepare a drug that inhibits the proliferation, migration and invasion of liver cancer cells in a ratio of (2.0-2.3):50. The inhibitory effect on cisplatin-resistant cells was verified through in vitro and in vivo experiments.

Benefits of technology

The combined use of tannin and cisplatin significantly inhibits the proliferation, migration, and invasion of liver cancer cells, reduces the risk of liver cancer metastasis, improves patient survival and quality of life, and provides a new treatment strategy for liver cancer.

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Abstract

The invention relates to the technical field of medicines, in particular to application of lasiokaurin and cis-platinum combined medicine in preparation of a medicine for treating liver cancer. As a diterpenoid compound, lasiokaurin shows significant potential in the anti-cancer field. However, in medical research and clinical application at present, related reports about combined use of lasiokaurin and a classical anti-cancer drug cis-platinum for treating liver cancer do not exist. Based on the current research situation, the invention creatively provides the application of the lasiokaurin and cis-platinum combined medicine in the aspect of preparing the liver cancer treatment medicine. In-depth study finds that lasiokaurin and cis-platinum can generate a synergistic effect and jointly play a strong anti-tumor role, and a brand new way is opened up for treatment of liver cancer.
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