TRIM50 mutant gene of Jingmen green-shell laying hens and application of TRIM50 mutant gene in regulation and control of cell growth
By identifying the TRIM50 mutant gene in Jingmen green-shelled chickens and constructing a recombinant vector, the shortcomings of existing technologies in poultry research on the TRIM50 gene were addressed. This enabled the construction of a high-viability cell model, promoting cell proliferation and inhibiting apoptosis, thereby enhancing the identification of animal growth performance and molecular breeding capabilities.
Patent Information
- Application Number
- CN202511741797.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-25
- Publication Date
- 2026-01-16
- Estimated Expiration
- 2045-11-25
AI Technical Summary
In existing technologies, the application of the TRIM50 gene of Jingmen green-shelled chicken in poultry research is limited, lacking regulatory effects on cell growth and molecular markers, which affects the progress of molecular-assisted breeding and biomedical research.
The TRIM50 mutant gene was identified in the Jingmen green-shelled chicken population, and recombinant vectors and recombinant microorganisms were constructed. Through transfection of cell models, cell proliferation was significantly promoted and cell apoptosis was inhibited, thus constructing a high-viability cell model.
It provides a highly viable and rapidly proliferating cell model, offering stable, efficient, and reliable biomaterials for the preparation of poultry vaccines and recombinant proteins, reducing costs, increasing yield and quality, and providing new genetic resources for the identification of animal growth performance and molecular-assisted breeding.